CSIR-Centre for Cellular and Molecular Biology | India
Dr. Anant Bahadur Patel is a leading neuroscientist specializing in brain energy metabolism and neurotransmitter energetics using advanced in vivo and ex vivo ^13C NMR spectroscopy. His research focuses on understanding how excitatory (glutamatergic) and inhibitory (GABAergic) neuronal activity, together with astroglial metabolism, support brain function in health and disease. By combining stable ^13C-labeled substrates (glucose and acetate) with metabolic modeling, his work quantitatively measures neuronal and astrocytic metabolic fluxes across different brain regions. Dr. Patel has made seminal contributions by demonstrating the tight stoichiometric coupling between neurotransmitter cycling and oxidative glucose metabolism, challenging the astrocyte–neuron lactate shuttle hypothesis and establishing neuronal glucose oxidation as a primary energy source. His laboratory pioneered regional neurometabolic mapping in the mouse brain and clarified astrocytic contributions to cerebral energetics. A major thrust of his research addresses neurological and psychiatric disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, depression, and addiction. He has identified early impairments in glutamate and GABA energetics as potential biomarkers for preclinical diagnosis and shown that neurometabolic deficits can be restored through pharmacological, dietary, and behavioral interventions. Overall, his work has significantly advanced quantitative neurometabolism and its translational relevance to brain disorders.
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