Mr. Yanjie Wang, Shanxi Medical University, China.
Yanjie Wang is a dedicated Ph.D. candidate in Otorhinolaryngology at Shanxi Medical University, with a strong foundation in clinical medicine and academic research. After earning his M.S. in 2020, he served as a Lecturer and Physician at the Second Hospital of Shanxi Medical University. Since 2022, his doctoral work under Prof. Changqing Zhao has centered on the neuroimmune mechanisms of airway hyperresponsiveness, especially the TRPV1 pathway’s role in allergic rhinitis. With active involvement in multiple national and provincial research projects, over ten scientific publications, and conference presentations, Mr. Wang has made significant strides in linking basic science with clinical relevance. His research highlights the interplay between peripheral allergens and central neural pathways and suggests novel therapeutic avenues for allergic airway diseases.
Profile
Scopus
🎓 Early Academic Pursuits
Yanjie Wang embarked on his academic journey in medical science at Shanxi Medical University, where he demonstrated a strong commitment to otorhinolaryngological studies early on. He earned his Master of Science degree in 2020, laying a firm foundation in clinical and research methodologies. His academic curiosity and rigor soon led him to pursue a Ph.D. in Otorhinolaryngology under the mentorship of Professor Changqing Zhao, where he delved deeply into the intricacies of airway neuroimmune mechanisms. This academic progression marked the beginning of a promising research trajectory focusing on allergic airway disorders.
🩺 Professional Endeavors
Following his M.S. degree, Mr. Wang began his clinical career as a Lecturer and Physician at the Second Hospital of Shanxi Medical University. Balancing patient care with academic responsibilities, he gained valuable experience in both educational instruction and clinical practice. In 2022, he transitioned into full-time doctoral research, dedicating his efforts to understanding the interplay between peripheral inflammation and central nervous regulation in respiratory conditions. His dual background in clinical service and research gives him a unique perspective in translational medicine.
🔬 Contributions and Research Focus
Mr. Wang’s research centers on the neuroimmune interactions involved in airway hyperresponsiveness, particularly allergic rhinitis (AR). His investigations have highlighted the upregulation of TRPV1 channels in AR patients and their correlation with symptom severity, including sneezing and nasal itching. Furthermore, he elucidated the TRPV1-NF-κB pathway’s role in allergen-induced IL-33 secretion in human nasal epithelial cells (hNECs), identifying TRPV1 as a critical modulator of nasal immune responses. His findings further demonstrate that TRPV1 inhibition significantly reduces OVA-induced innate nasal epithelial activation, offering potential therapeutic implications.
🧪 Research Projects and Innovation
Through his active involvement in cutting-edge research, Mr. Wang has participated in three projects funded by the National Natural Science Foundation and led two significant provincial grants—namely the Basic Research Project of Shanxi Province (No. 202203021222390) and the Youth Project of the Second Hospital of Shanxi Medical University (No. 202302-9). These projects have advanced understanding of epithelial immune responses and neuroimmune regulation in allergic diseases. His ability to merge molecular biology, immunology, and clinical perspectives has positioned him as a rising voice in the field of upper airway disease research.
🏅 Accolades and Recognition
Yanjie Wang’s dedication to research and clinical advancement has resulted in more than ten peer-reviewed publications in SCI and other core journals. His work has not only been published but also presented at multiple national academic conferences, earning respect from peers and experts alike. His increasing citation index—marked by the notable 2025 publication on TRPV1 inhibition in nasal inflammation—reflects the relevance and growing impact of his work in both national and international scientific communities.
🌍 Impact and Influence
Mr. Wang’s studies contribute meaningfully to the understanding of allergic airway disease mechanisms, especially regarding epithelial-neural-immune crosstalk. His research outcomes have the potential to reshape therapeutic approaches for allergic rhinitis by targeting neuroimmune pathways rather than relying solely on antihistamines and corticosteroids. Through mentorship and interdisciplinary collaboration, he is fostering a network of emerging scholars and promoting evidence-based advancements in respiratory immunology.
🚀 Legacy and Future Contributions
Looking ahead, Yanjie Wang is poised to become a leading expert in airway neuroimmunology. His future ambitions include translating his basic research into clinical innovations that improve patient outcomes and developing novel therapeutic strategies targeting TRP channels in allergic diseases. His commitment to merging scientific exploration with clinical relevance ensures that his work will leave a lasting legacy in otorhinolaryngological research and patient care.
Publication
Title: Inhibition of TRPV1 attenuates innate nasal epithelial responses via NF-κB signaling pathway in allergic rhinitis
Authors: Wang, Yanjie; Qi, Xueping; Li, Hanxiong; Cheng, Fengli; Zhao, Changqing
Year: 2025
✅ Conclusion
Yanjie Wang stands out as a promising scholar whose work bridges clinical practice and experimental science. His research into TRPV1-mediated neuroimmune responses is not only timely but potentially transformative in treating allergic airway conditions. As he continues to deepen his investigations and expand his academic impact, his contributions are expected to drive innovation in the diagnosis, management, and therapy of upper airway disorders. His career trajectory signals a future leader in respiratory immunology and translational otorhinolaryngological research.