Wilfred Angie Abia | Developmental Neuroscience | Best Researcher Award

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Dr. Wilfred Angie Abia | Developmental Neuroscience | Best Researcher Award

Dr. Wilfred Angie Abia |  University of Yaounde 1 | Cameroon

Wilfred Angie Abia is an accomplished biochemist and food safety toxicologist whose career bridges Africa and Europe through impactful teaching, research, and international collaborations. His academic foundation in medical biochemistry, nutrition, and toxicology has evolved into a distinguished career specializing in food contaminants, mycotoxin biomonitoring, fraud detection, and risk assessment. He has held influential postdoctoral and leadership positions in projects addressing agri-food safety and consumer health protection. His contributions span mycotoxicology, food fraud prevention, One Health research, and climate-related food safety challenges. Beyond research, he plays an important role as a senior lecturer and mentor, advancing both academic excellence and professional training in food safety.

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Early Academic Pursuits

Wilfred Angie Abia began his academic journey with a strong foundation in biochemistry, focusing on medical laboratory technology, nutritional sciences, and food safety. His doctoral studies at the University of Yaoundé I provided him with advanced expertise in food contaminants, safety, and biomonitoring of multimycotoxin exposures. His early academic years were marked by interdisciplinary training that connected biochemistry, nutrition, toxicology, and public health, setting the stage for his specialized career in agri-food safety and toxicology.

Professional Endeavors

His professional career spans teaching, research, and project management across multiple institutions and international collaborations. He has held postdoctoral fellowships and senior research positions in Africa, Europe, and the United Kingdom, where he advanced projects on food safety, toxicology, and fraud detection. His work at Queen’s University Belfast included leadership roles in large-scale European initiatives, where he served as both a researcher and project manager. As a Senior Lecturer of Biochemistry and Food Safety/Toxicology at the University of Yaoundé I, he combines teaching, mentorship, and research with program coordination responsibilities, shaping the next generation of food safety professionals.

Contributions and Research Focus

Abia’s research focuses on food contaminants, safety, and human health with a special emphasis on mycotoxicology. He has pioneered studies in exposure assessment, biomarker development, and human biomonitoring, particularly in vulnerable populations. His work extends to food integrity, authenticity, fraud detection, and traceability, ensuring consumer health protection. He has contributed significantly to toxicological risk assessments of chemicals in food, drugs, and the environment, while also addressing broader themes such as climate change, food security, and the One Health approach. His unique contributions include research into the neurotoxicology of mycotoxins, highlighting the intersection of food safety and neuroscience.

Accolades and Recognition

Throughout his career, Abia has been recognized through prestigious international research fellowships and visiting scholar positions in leading research centers across Europe and Africa. His involvement in high-impact projects such as MycoMarker and FoodSafer underscores his leadership in global food safety initiatives. His achievements are further strengthened by professional certifications, including specialized training in food fraud prevention, which demonstrate his commitment to continuous professional growth and excellence in his field.

Impact and Influence

His work has had a profound impact on advancing food safety research, shaping policies, and protecting public health. By bridging biochemistry with toxicology, agri-food safety, and environmental sciences, he has influenced how food contaminants and fraud are detected and managed. His role as a lecturer and mentor ensures that his expertise is transmitted to students and young researchers who will continue to advance the field. His contributions also extend to policy and science diplomacy, where he actively promotes interdisciplinary collaboration for sustainable solutions in food and health security.

Legacy and Future Contributions

Abia’s legacy lies in his dedication to safeguarding food systems, advancing toxicological research, and promoting interdisciplinary approaches that connect human, animal, and environmental health. His work in mycotoxin biomonitoring and neurotoxicology offers critical insights into the hidden health risks of food contamination. Looking ahead, his future contributions are likely to expand in areas of food fraud prevention, climate-smart agriculture, and One Health frameworks, ensuring resilient food systems for global populations. His combination of research excellence, teaching, and science diplomacy positions him as a thought leader in shaping the future of food safety and toxicology.

Publications

  • Title: Determination of multi-mycotoxin occurrence in cereals, nuts and their products in Cameroon by liquid chromatography tandem mass spectrometry (LC-MS/MS)
    Authors: WA Abia, B Warth, M Sulyok, R Krska, AN Tchana, PB Njobeh, MF Dutton, …
    Year: 2013

  • Title: Mycotoxin exposure in rural residents in northern Nigeria: A pilot study using multi-urinary biomarkers
    Authors: CN Ezekiel, B Warth, IM Ogara, WA Abia, VC Ezekiel, J Atehnkeng, …
    Year: 2014

  • Title: Development and validation of a rapid multi‐biomarker liquid chromatography/tandem mass spectrometry method to assess human exposure to mycotoxins
    Authors: B Warth, M Sulyok, P Fruhmann, H Mikula, F Berthiller, R Schuhmacher, …
    Year: 2012

  • Title: Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach
    Authors: WA Abia, B Warth, M Sulyok, R Krska, A Tchana, PB Njobeh, PC Turner, …
    Year: 2013

  • Title: Ultra-sensitive, stable isotope assisted quantification of multiple urinary mycotoxin exposure biomarkers
    Authors: B Šarkanj, CN Ezekiel, PC Turner, WA Abia, M Rychlik, R Krska, M Sulyok, …
    Year: 2018

  • Title: Low doses of mycotoxin mixtures below EU regulatory limits can negatively affect the performance of broiler chickens: A longitudinal study
    Authors: O Kolawole, A Graham, C Donaldson, B Owens, WA Abia, J Meneely, …
    Year: 2020

  • Title: Urinary analysis reveals high deoxynivalenol exposure in pregnant women from Croatia
    Authors: B Šarkanj, B Warth, S Uhlig, WA Abia, M Sulyok, T Klapec, R Krska, …
    Year: 2013

Conclusion

Wilfred Angie Abia’s work exemplifies a rare integration of scientific expertise, international leadership, and educational impact. His contributions to food safety, toxicology, and agri-food research not only safeguard public health but also strengthen global food systems. With his continued focus on innovation, interdisciplinary approaches, and capacity building, he stands as a key figure in shaping the future of food safety science and policy worldwide.

Stanley Zimba | Clinical Neuroscience | Best Researcher Award

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Dr. Stanley Zimba | Clinical Neuroscience | Best Researcher Award

Dr. Stanley Zimba | University of Zambia School of Medicine | Zambia

Stanley Zimba is a distinguished neurologist and academic whose career reflects a rare blend of clinical excellence, research innovation, and medical leadership. With a strong educational foundation in medicine and advanced training in neurology, he has dedicated himself to improving neurological care and education in Zambia. His professional endeavors span across clinical practice in leading hospitals, teaching roles at multiple universities, and leadership in professional organizations. His research has focused on neuroHIV, neuromuscular disorders, and epilepsy, often conducted in collaboration with globally recognized institutions. His outstanding work has earned him prestigious international fellowships, awards, and recognition, making him a prominent voice in neurology within sub-Saharan Africa.

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Early Academic Pursuits

Stanley Zimba began his academic journey with a strong foundation in the sciences, excelling early in his studies and securing recognition as one of the most outstanding students of his time. His pursuit of higher education led him to the University of Zambia, where he undertook rigorous training in medicine. He first completed a degree in Human Biology before advancing to obtain his Bachelor of Medicine and Bachelor of Surgery. His intellectual curiosity and commitment to medical excellence propelled him to further specialization with a Master of Medicine in Internal Medicine. Driven by a passion for advancing neurological sciences, he embarked on advanced fellowship training in Adult Neurology and later pursued doctoral research in Adult Neurology at the University of Zambia, building the foundation for his career as a clinician–scientist.

Professional Endeavors

Zimba’s professional career has been deeply rooted in both clinical practice and academic medicine. As a consultant neurologist, he has played a central role in establishing neurology services within Zambia’s leading medical institutions, including the University Teaching Hospital where he leads the Neurology and Hematology Unit. His expertise has been sought by private hospitals, where he contributes to expanding access to specialized neurological care. Beyond hospital practice, his influence extends into academia, where he serves as an honorary lecturer across several medical universities in Zambia, shaping the next generation of physicians. His leadership extends further into professional organizations, where he has assumed prominent roles that guide the direction of neurological practice and training within the country.

Contributions and Research Focus

At the heart of Zimba’s career lies a dedication to advancing knowledge in neurology, with particular attention to neurological complications of infectious diseases, neuroHIV, neuromuscular disorders, and epilepsy. His research activities have been strengthened through international collaborations with institutions such as Johns Hopkins University, Harvard University, and the University of Cape Town. He has engaged in translational research exploring the interface between infectious diseases and neurological health, addressing critical gaps in understanding how conditions such as HIV contribute to neurological morbidity. His academic work reflects a blend of clinical expertise and research innovation, positioning him as a leading figure in developing evidence-based approaches to neurological care in sub-Saharan Africa.

Accolades and Recognition

Zimba’s academic and professional journey has been marked by significant recognition from both local and international institutions. He has received prestigious scholarships and fellowships from globally renowned organizations, including the American Academy of Neurology, the Fogarty International Center, and the Peripheral Nerve Society. His contributions have also been acknowledged through competitive awards for scholarly excellence, such as recognition for best scientific presentations and leadership fellowships in global health research. These honors reflect not only his personal commitment to academic excellence but also the international value of his work in neurology.

Impact and Influence

Through his roles in clinical practice, teaching, and leadership, Zimba has had a profound impact on the development of neurology in Zambia. As head of neurology services in the nation’s largest teaching hospital, he has shaped clinical protocols and advanced the training of physicians in specialized neurological care. His academic mentorship has inspired many young medical professionals to pursue careers in neurology and internal medicine. His leadership in professional associations has also created platforms for collaboration, advocacy, and policy development, ensuring that neurological health remains a priority in national and regional health agendas.

Legacy in Medical Leadership

Zimba’s leadership extends beyond the clinic and classroom into national medical governance. By directing specialist training programs and contributing to the regulation of internal medicine through the Health Professions Council of Zambia, he has influenced the standards of medical education and practice across the country. His presidency of the Neurological Association of Zambia positions him as a central figure in shaping the future of neurological practice, advocacy, and awareness, ensuring that patients with neurological disorders receive improved recognition and care.

Future Contributions

Looking forward, Zimba is poised to leave a lasting legacy through his continued commitment to advancing neurological sciences in Zambia and the wider region. His doctoral research and international collaborations promise to generate new insights into neurological disease management, while his leadership roles will likely foster stronger systems for specialist training and healthcare delivery. By combining clinical expertise, academic mentorship, and institutional leadership, he is set to play an instrumental role in positioning Zambia as a center of excellence for neurology in Africa. His career trajectory illustrates a deep dedication not only to scientific advancement but also to the betterment of patient care and health systems in resource-limited settings.

Publications

The Association of Premature Atherosclerosis with Ischemic Stroke in Young People with HIV in Lusaka, Zambia
Authors: Stanley Zimba; Owen Ngalamika; Emmanuel Mukambo; Theresa Shankanga; Bwalya Mulenga; Mike Chisha; Violet Kayamba; Lloyd Mulenga; Omar Siddiqi; Owen A. Ross et al.
Year: 2025

Clinical Reasoning: Rapidly Progressive Dementia in a Man With HIV Infection and Undetectable Plasma Viral Load
Authors: Lorraine Chishimba Chishimba; Mashina Chomba; Stanley Zimba; Melody Tunsubilege Asukile; Obrie Makai; Deanna R. Saylor
Year: 2023

The case of a 42‐year‐old man with progressive gait instability, dysarthria, and dysphagia
Authors: Jennifer Adrissi; Mashina Chomba; Lorraine Chishimba; Stanley Zimba; Igor J. Koralnik; Deanna Saylor
Year: 2023

A Notable Prevalence of HIV-Associated Stroke in an Endemic Region
Authors: Stanley Zimba; Laura Benjamin
Year: 2022

Implementation of a Teleneurology Clinic in Zambia during the COVID‐19 Pandemic
Authors: Melody Asukile; Lorraine Chishimba; Mashina Chomba; Moses Mataa; Frighton Mutete; Naluca Mwendaweli; Kunda Yumbe; Stanley Zimba; Gloria Habanyama; Sydney Shampile et al.
Year: 2022

Inpatient Management of Acute Stroke of Unknown Type in Resource-Limited Settings
Authors: Morgan L. Prust; Deanna Saylor; Stanley Zimba; Fred Stephen Sarfo; Gentle S. Shrestha; Aaron Berkowitz; Nirali Vora
Year: 2022

Clinical Reasoning: An Unusual Case of Acute Psychosis and Tetraparesis in a Young Zambian Man
Authors: Stanley Zimba; Lorraine Chishimba; Mashina Chomba; Deanna Saylor
Year: 2021

Immune reconstitution inflammatory syndrome: a report of TB-IRIS after switching from efavirenz to dolutegravir
Authors: Stanley Zimba; Nyuma Mbewe; Lorraine Chishimba; Mashina Chomba; Deanna Saylor
Year: 2021

Conclusion

Dr. Zimba’s contributions exemplify the qualities of a transformative clinician–scientist who bridges research, practice, and leadership. His work has significantly advanced the understanding and treatment of neurological disorders in Zambia, while also elevating medical education and training standards. Through his leadership positions, he has shaped healthcare policy, specialist training, and advocacy for neurological health. Looking to the future, his research and leadership promise to strengthen neurology as a field in Africa, leaving a legacy of scientific advancement, patient-centered care, and mentorship for future generations.

Deepika Singhal | Neurophysiology | Best Researcher Award

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Ms. Deepika Singhal | Neurophysiology | Best Researcher Award

Ms. Deepika Singhal | Medical Faculty Mannheim | Germany

Deepika Singhal is an emerging neurophysiologist whose academic path has been marked by consistent excellence from her early training in biochemistry and biotechnology to her advanced doctoral research in chronic pain mechanisms. Her professional journey spans leading institutions in India, Germany, the United States, and the United Kingdom, where she has gained expertise in molecular biology, neurophysiology, and computational genomics. Her research focuses on uncovering sex differences in stress-induced predisposition to chronic low back pain, combining behavioral models, molecular assays, and bioinformatics approaches. In addition to her scientific achievements, she has demonstrated leadership by managing research teams, securing competitive grants, organizing international symposia, and contributing to peer-reviewed publications.

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Early Academic Pursuits

Deepika Singhal began her academic journey with a strong foundation in the life sciences, pursuing studies in biochemistry and medical biotechnology. Her early academic training fostered a deep curiosity about the molecular basis of health and disease. During her master’s studies, she undertook research on genetic and epigenetic alterations in neurotransmitter systems associated with opioid dependence, which provided her with essential skills in molecular biology and an appreciation for the complexity of neurobiological processes. This early immersion in both theoretical knowledge and practical laboratory work laid the groundwork for her future specialization in neurophysiology.

Professional Endeavors

Building upon her academic preparation, Deepika advanced into diverse research roles across India and Germany, contributing to large-scale genomic and molecular studies. She gained valuable experience at leading institutes where she developed expertise in genome-wide association studies and microbiome-based therapeutic workflows. Transitioning to Europe, she joined research programs that expanded her skill set into preclinical pain research and computational biology. As a doctoral candidate in neurophysiology, she has since led independent research projects, managed international collaborations, and supervised junior researchers, blending scientific rigor with leadership and project management.

Contributions and Research Focus

Deepika’s primary research focus lies in understanding the biological underpinnings of chronic pain, with particular emphasis on sex differences in stress-related mechanisms. Her doctoral work investigates how adolescent stress predisposes males and females differently to chronic low back pain in adulthood, combining behavioral assays, molecular analysis, and high-resolution imaging techniques. Her findings have revealed striking differences between latent and manifest sensitization in males and females, linked to microglial priming and gene expression patterns. This work contributes to a growing body of knowledge that seeks to develop sex-specific therapeutic strategies for chronic pain disorders.

Collaborative Engagements

Deepika’s research has been enriched by international collaborations with renowned laboratories in the United States and the United Kingdom. Working with experts in molecular pain research, she has optimized sequencing protocols, developed advanced bioinformatics pipelines, and contributed to manuscripts exploring microglial activation and its modulation. These collaborations highlight her ability to integrate diverse methodologies and perspectives, strengthening the translational potential of her findings.

Accolades and Recognition

Her academic and research achievements have been acknowledged through competitive fellowships, awards, and invitations to leading scientific schools and congresses. She has been recognized for innovative research proposals, successfully secured funding for symposia, and earned fellowships that supported her international training. Her selection as a scholar at the European Pain School reflects her standing in the global scientific community, while leadership roles in academic associations demonstrate her commitment to advancing both her field and the scientific environment around her.

Impact and Influence

Beyond her research contributions, Deepika has actively shaped the academic community through leadership and organizational roles. As a representative in her doctoral program, she has spearheaded student-led initiatives, organized symposia, and created platforms for scientific exchange, ensuring a vibrant research culture. Her experience as a peer reviewer and conference presenter underscores her role in disseminating knowledge and influencing the discourse on pain mechanisms and neurophysiology at large. Her application of machine learning tools to complex biological data reflects a forward-looking approach that bridges experimental and computational neuroscience.

Legacy and Future Contributions

Deepika Singhal’s career reflects a trajectory of academic excellence, innovative research, and dedicated leadership. By addressing the pressing challenge of sex-specific mechanisms in chronic pain, her work not only deepens scientific understanding but also holds the promise of influencing future therapeutic approaches. Her combination of laboratory expertise, computational acumen, and collaborative spirit positions her to continue contributing significantly to neuroscience and pain research. Looking ahead, her endeavors are likely to leave a lasting legacy in both advancing fundamental science and improving clinical perspectives on chronic pain disorders.

Publications

  • Title: Sex Differences in the Effects of Early Life Stressors in a Rat Model of Myofascial Low Back Pain
    Authors: Deepika Singhal; Lin Li; Wolfgang Greffrath; Rolf‐Detlef Treede
    Year: 2025

  • Title: Sex differences in functional modulation of microglia by early-life physical stress in a rat model of chronic primary low back pain
    Authors: Deepika Singhal; Jonathan R. Husk; Wolfgang Greffrath; Rolf-Detlef Treede
    Year: 2025

  • Title: Association of Serotonergic Pathway Gene Polymorphisms With Behavioral Parameters in Patients With Opioid Dependence
    Authors: Siddharth Sarkar; Renu Singh; Arundhati Sharma; Muzaffar A Pandit; Ranjan Gupta; Deepika Singhal; Raka Jain; Yatan P Balhara
    Year: 2021

Conclusion

Through her multidisciplinary expertise and international collaborations, Deepika Singhal has made impactful contributions to the field of neuroscience, particularly in understanding sex-specific mechanisms of chronic pain. Her ability to integrate molecular biology, data science, and preclinical research highlights her innovative approach to addressing complex biomedical challenges. With a record of awards, leadership roles, and peer recognition, she stands as a promising researcher whose future contributions are poised to advance both scientific discovery and clinical understanding in neurophysiology and pain research.

Becky Riggs | Neuroimaging | Best Researcher Award

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Dr. Becky Riggs | Neuroimaging | Best Researcher Award

Dr. Becky Riggs |  OHSU Doernbecher Children’s Hospital | United States

Dr. Rebecca J. Riggs is an accomplished physician–scientist and academic leader in pediatric critical care and neurocritical care. With advanced training in pediatrics, critical care, and neurocritical care at top U.S. institutions, she has built a career that blends clinical excellence, research innovation, and educational leadership. Her research centers on ultrasound medicine, neuro-monitoring, viral pathogens affecting the nervous system, and neurodevelopmental outcomes of critically ill children. She has served as principal investigator in national multi-center studies funded by the NIH and CDC, contributing to evidence-based guidelines for conditions such as acute flaccid myelitis and pediatric COVID-19. Alongside her research, she has directed neurocritical care programs, led safety and quality initiatives, and mentored future physicians. Her work demonstrates a rare combination of technical expertise, collaborative leadership, and a commitment to advancing both patient care and the broader field of pediatric intensive care medicine.

Profile

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Early Academic Pursuits

Rebecca J. Riggs, widely known as Becky, laid the foundation for her medical career through an early commitment to both emergency medicine and the social sciences. With training as an emergency medical technician and paramedic, followed by a degree in women’s studies, she cultivated a broad perspective that combined scientific rigor with a deep awareness of social contexts. This unique academic blend informed her later clinical approach, emphasizing both medical expertise and patient-centered care. She advanced her education by completing her medical degree at the University of Tennessee College of Medicine, and subsequently pursued specialized training in pediatrics, pediatric critical care, and pediatric neurocritical care at leading institutions across the United States.

Professional Endeavors

Dr. Riggs’ professional path reflects her dedication to pediatric intensive care and academic medicine. She held early faculty roles at Johns Hopkins University School of Medicine, where she became a key figure in pediatric anesthesiology and critical care medicine. Her work extended beyond bedside care into administrative leadership, including directing pediatric neurocritical care services and serving on multiple institutional committees aimed at advancing patient safety, quality improvement, and team culture within the intensive care environment. Later, her transition to Oregon Health & Science University marked a continuation of her leadership in pediatric critical care, where she now serves as an associate professor and directs programs that integrate neurology, cardiology, and intensive care.

Contributions to Neurocritical Care

Central to Dr. Riggs’ career has been her pioneering contributions to the development and expansion of pediatric neurocritical care. She co-directed and later directed programs that established protocols, pathways, and education models for the care of critically ill children with neurological conditions. Her leadership in culture change initiatives within the pediatric intensive care unit highlights her commitment to improving team dynamics and patient-centered outcomes. She has also served as a mentor and educator, leading simulations, workshops, and educational events to strengthen the capacity of clinicians in this demanding subspecialty.

Research Focus

Dr. Riggs’ scholarly contributions are strongly anchored in her research on ultrasound medicine and neuro-monitoring in critically ill children. Her investigations include ophthalmic ultrasonography, neurosonography, and contrast-enhanced ultrasonography, all aimed at enhancing diagnostic accuracy and monitoring in neonatal and pediatric intensive care settings. She has been particularly engaged in studying viral pathogens with neurological effects and in examining the neurodevelopmental outcomes of children after critical illness. Her role as site principal investigator for multi-center studies funded by the NIH and CDC underscores her central position in national efforts to improve understanding and care of acute flaccid myelitis and pediatric COVID-19 outcomes.

Leadership in Collaborative Studies

Dr. Riggs has played a vital role in large-scale, collaborative pediatric studies of national importance. She served as the Johns Hopkins site principal investigator for the NIH-funded Acute Flaccid Myelitis Natural History study, contributing to the creation of evidence-based guidelines for this rare but devastating condition. She also guided institutional involvement in the CDC-funded Overcoming COVID-19 study, which shaped the understanding of how children are affected by emerging viral illnesses. Through these collaborations, she has demonstrated an ability to bridge clinical expertise with research that informs global health policy and clinical standards.

Accolades and Recognition

Her research achievements have been supported by competitive federal funding, including NIH Loan Repayment Program awards for her pioneering work in pediatric ophthalmic ultrasound and imaging in cases of traumatic brain injury. These grants reflect recognition of both the novelty and impact of her research directions. Her leadership appointments at Johns Hopkins and Oregon Health & Science University further testify to her peers’ trust in her capacity to shape the future of pediatric critical care medicine.

Impact, Influence, and Future Contributions

The impact of Dr. Riggs’ work is evident in the improved protocols, expanded research pathways, and enhanced patient care strategies she has championed. By integrating ultrasound technology into pediatric neurocritical care, she has opened new avenues for bedside diagnostics and monitoring. Her influence extends through her leadership in guideline development, her mentorship of future physicians, and her advocacy for collaborative approaches to rare and emerging pediatric conditions. Looking ahead, her ongoing research and clinical leadership are poised to further shape the evolving field of pediatric neurocritical care, leaving a legacy of innovation, compassion, and transformative impact on children’s health worldwide.

Publications

1. Ophthalmic ultrasonography can identify retinal injury associated with abusive head trauma more quickly and accurately than other neuroimaging modalities — Authors: (not listed), 2025

2. A novel approach to thrombectomy and catheter directed tissue-type plasminogen activator in a toddler post-fontan — Authors: (not listed), 2024

Conclusion

Dr. Riggs’ career reflects a profound dedication to improving the lives of critically ill children through innovation in research, excellence in clinical care, and leadership in program development. Her contributions have significantly advanced pediatric neurocritical care by integrating novel diagnostic tools, shaping national guidelines, and fostering collaborative research networks. With her continued focus on emerging pathogens and neurodevelopmental outcomes, she is poised to further influence the future of pediatric intensive care on both national and international levels. Her legacy will be defined by her impact on patient outcomes, her mentorship of future leaders, and her role in shaping the evolving landscape of pediatric neurocritical care.

 

Ali Moghimi | Behavioral Neuroscience | Best Researcher Award

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Prof. Dr. Ali Moghimi | Behavioral Neuroscience | Best Researcher Award

Prof. Dr. Ali Moghimi |  Ferdowsi University of Mashhad  | Iran

Ali Moghimi is a distinguished professor of neurophysiology whose career has been deeply rooted in the study of animal and human physiology, with a special focus on neurological disorders such as epilepsy, depression, and memory impairments. His early academic training in veterinary medicine and his doctoral work in physiology laid a strong foundation for his extensive contributions to neuroscience. Over the years, he has combined behavioral experiments with electrophysiological methods to explore complex brain mechanisms, advancing both theoretical knowledge and practical applications in the field. Alongside his research, he has played significant administrative and leadership roles at Ferdowsi University of Mashhad, shaping the academic and research landscape while mentoring the next generation of scientists.

Profile

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Early Academic Pursuits

Ali Moghimi began his educational journey with a strong interest in the life sciences, eventually pursuing advanced studies in veterinary medicine at Tehran University. His passion for physiology and neuroscience led him further to Moscow State University, where he specialized in human and animal physiology. During this period, he dedicated his doctoral research to exploring the effects of polycyclic preparations and endothelin on convulsions and absence seizures in animal models. His academic foundation was built upon a rigorous blend of behavioral and electrophysiological studies, which shaped his future direction in neurophysiology.

Professional Endeavors

Following his graduation, he embarked on an academic career as an instructor in animal husbandry and physiology. His dedication to teaching and research soon established him as a key figure in his field, culminating in his long-standing role as Professor of Neurophysiology at Ferdowsi University of Mashhad. Over the years, he has held several leadership positions within the university, including departmental headships, directorships in research affairs, and even the deanship of the Faculty of Science, reflecting his deep commitment to academic growth and institutional development.

Contributions and Research Focus

Moghimi’s research has consistently revolved around neurophysiology, with a particular emphasis on experimental models of learning, memory, depression, and epilepsy. He has conducted in-depth studies on animal behavior using advanced techniques such as Morris water maze, radial maze, and electrophysiological recordings. His expertise extends to stereotaxic surgical methods, electrode implantations, hippocampal slice preparations, and EEG recordings. Through this, he has significantly advanced understanding of epileptiform convulsions, febrile seizures, and neural mechanisms underlying cognitive and affective behaviors.

Accolades and Recognition

His reputation as a researcher and academic leader has earned him invitations to present his work at numerous national and international conferences. His publications in both Iranian and international journals demonstrate his role as a prolific contributor to neuroscience and physiology. In addition to his research, his service as a reviewer for several prestigious scientific journals highlights the recognition of his expertise by the wider scientific community.

Impact and Influence

Through his dual role as a researcher and educator, Moghimi has influenced a generation of students and scholars in physiology and neuroscience. His efforts to establish and lead research initiatives at Ferdowsi University of Mashhad have fostered a culture of inquiry and innovation. By bridging experimental animal studies with human neurological insights, he has provided valuable frameworks for understanding neurological disorders and their potential treatments.

Legacy in Scientific Societies

His membership in several national scientific societies, ranging from physiology and pharmacology to epilepsy and animal rights, reflects his broad engagement with the scientific community. His involvement not only highlights his professional recognition but also his commitment to ethical practices in animal research. His advocacy for scientific integrity and responsible experimentation has left an enduring mark on both his students and colleagues.

Future Contributions

Looking ahead, Ali Moghimi’s ongoing research and mentorship are set to continue shaping the field of neurophysiology. His ability to integrate behavioral, physiological, and electrophysiological approaches positions him as a key contributor to future advancements in understanding brain function and neurological disorders. His legacy will be defined not only by his published works and academic leadership but also by the scientific curiosity and ethical values he instills in future generations of neuroscientists.

Publications

  • Auditory Salience Detection Across Wake and Sleep States: Mismatch Negativity and Event‐Related Spectral Perturbation in the Rat Superior Colliculus – Javad Hasan Nia Roshan; Ali Moghimi; Ali Gorji; Amir Shojaei; Vladyslav V. Vyazovskiy – 2025

  • Disgust-Reduction Evaluative Conditioning (DREC) and tDCS in Contamination-Based OCD: A Randomized Controlled Trial – Faezeh Raeis Al Mohaddesin; Ali Moghimi; Hamidreza Kobravi; Elahe Yaghoubian; Javad Salehi Fadardi – 2025

  • Disgust-reduction evaluative conditioning (DREC) and brain stimulation in patients with contamination-based obsessive-compulsive disorder: a protocol for a randomized control trial – Faezeh Raeis Al Mohaddesin; Ali Moghimi; Javad Salehi Fadardi – 2023

  • Behavioral and electrophysiological (ECoG) effects of haplophyllum robustum and TRPA1 antagonist in adult male wistar rats – Maedeh Rahati Quchani; Elham Farmanesh; Asieh Esmaili; Ali Moghimi; Masoud Fereidoni; Saeed Rahati Quchani – 2023

  • Effect of stress on spatial working memory and EEG signal dynamics in the follicular and luteal phases of the menstrual cycle in young single girls – Malihe Eskandari Torbaghan; Ali Moghimi; Hamid Reza Kobravi; Masoud Fereidoni; Imanollah Bigdeli – 2023

  • Effects of citicoline and atorvastatin administration on the regenerative capacity of the distal segment of the transected sciatic nerve in conditions of delayed nerve repair – Bolandghamat, S.; Behnam-Rassouli, M.; Mahdavi-Shahri, N.; Moghimi, A. – 2022

  • Enhancing the Anticonvulsant Effects of Nifedipine in Rats Through Encapsulation with Water-Soluble β-Cyclodextrin Polymer – Hashemi, M.; Abbasnejad, M.; Moghimi, A.; Esmaeili-Mahani, S.; Zamyad, M.; Heydari, A. – 2022

Conclusion

The academic journey of Ali Moghimi reflects a life dedicated to scientific exploration, teaching, and leadership in neurophysiology. His contributions to behavioral neuroscience, epilepsy research, and experimental physiology have established him as a respected figure in both national and international scientific communities. Through his publications, conference presentations, and active participation in scientific societies, he has made lasting impacts on the study of brain function and neurological health. His legacy is not only marked by his own research achievements but also by the knowledge, inspiration, and ethical values he imparts to his students and colleagues, ensuring a continuing influence on the future of neuroscience.

David Cooper | Brain Death | Best Extension Activity Award

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Dr. David Cooper | Brain Death | Best Extension Activity Award

Dr. David Cooper |  Massachusetts General Hospital | United States

David K. C. Cooper is a globally renowned surgeon-scientist whose career has been defined by groundbreaking contributions to transplantation and xenotransplantation. Trained in London and Cambridge under eminent surgical leaders, he went on to hold major academic and clinical positions in South Africa, the United States, and most recently at Massachusetts General Hospital/Harvard Medical School. His early work advanced heart preservation and donor management, while his later research pioneered the identification of immune barriers in xenotransplantation and strategies for genetic engineering of pigs as organ sources. Over decades, he has authored more than a thousand scientific works, edited major textbooks, mentored generations of scientists, and held leadership roles in international transplantation societies. Widely recognized with fellowships, lectureships, medals, and awards, his influence spans clinical innovation, basic science, mentorship, and global collaboration.

Profile

Scopus

Early Academic Pursuits

David K. C. Cooper began his academic journey in London, where he pursued his medical education at Guy’s Hospital Medical School in the University of London. His formative years in medicine were shaped not only by rigorous clinical training but also by an early exposure to groundbreaking developments in cardiac surgery and transplantation. He trained under some of the most distinguished figures in surgery and medicine, an experience that inspired his lifelong commitment to advancing the field of organ transplantation. His early research culminated in a doctoral degree in which he investigated methods of heart resuscitation and preservation, establishing the scientific foundation for his later contributions to clinical and experimental transplantation sciences.

Professional Endeavors in Surgery and Transplantation

Dr. Cooper’s professional career has spanned continents and decades, encompassing appointments in England, South Africa, the United States, and later at leading institutions in Boston and beyond. In South Africa, at the University of Cape Town and Groote Schuur Hospital, he worked alongside Christiaan Barnard and took responsibility for the heart transplant program, simultaneously developing new methods of donor organ preservation and care. His career further evolved with significant roles in the United States, including his work at the Oklahoma Transplantation Institute, the Massachusetts General Hospital, the University of Pittsburgh, and the University of Alabama at Birmingham. Across these roles, he combined clinical practice with pioneering experimental research, contributing to the foundation of xenotransplantation as a viable field of study.

Contributions and Research Focus

The central theme of Cooper’s scientific journey has been transplantation science, with a particular emphasis on xenotransplantation. He was among the first to identify the key antigen responsible for immune rejection of pig organs by human antibodies, a discovery that opened the door to genetically engineering donor pigs for human transplantation. His work also addressed the physiological changes following brain death in potential donors, which led to the adoption of hormonal replacement therapy that is now applied worldwide. Over the decades, his laboratory has been at the forefront of understanding immune barriers, developing organ preservation systems, and promoting translational strategies that brought xenotransplantation closer to clinical reality. His leadership in NIH-funded projects and collaborations with biotechnology companies has further strengthened the translational bridge between bench and bedside.

Scholarly Contributions and Knowledge Dissemination

An integral part of Cooper’s career has been his role in advancing the body of scientific literature. He has authored and co-authored more than a thousand papers and chapters, as well as multiple authoritative textbooks that remain cornerstones in transplantation and xenotransplantation. His editorial leadership, notably as the Editor-in-Chief of Xenotransplantation, reflects his commitment to shaping academic discourse and guiding scientific progress. In addition to specialist texts, he has also authored books intended for a broader audience, thereby making complex scientific achievements accessible to the general public.

Accolades and Recognition

Cooper’s exceptional contributions have been recognized with prestigious honors from surgical colleges, transplantation societies, and international scientific associations. His awards include lectureships, professorships, and distinguished medals that underscore his impact on transplantation medicine. He has been elected to fellowships in major professional organizations and honored by both academic and clinical bodies for his pioneering role in advancing xenotransplantation research. These accolades reflect not only his groundbreaking discoveries but also his leadership in shaping global transplantation practice and policy.

Impact and Influence on the Scientific Community

Beyond his research achievements, Cooper has left a lasting mark through mentorship and global collaboration. He has trained and guided more than a hundred postgraduate and postdoctoral scholars, many of whom have become leaders in their fields. His extensive invited lectures on five continents have ensured the wide dissemination of knowledge, while his service in professional societies has strengthened the organizational foundations of the transplantation community. His role in establishing and leading the International Xenotransplantation Association reflects his influence in consolidating a global scientific network dedicated to one of medicine’s most challenging frontiers.

Legacy and Future Contributions

David K. C. Cooper’s career represents a bridge between the pioneering heart transplant era of the twentieth century and the emerging field of gene-edited organ xenotransplantation in the twenty-first. His experimental and translational work provided essential groundwork for the first gene-edited pig heart transplant into a human recipient. His enduring legacy lies not only in his scientific achievements but also in his vision of making organ shortage a solvable challenge. As xenotransplantation moves toward clinical application, Cooper’s contributions continue to guide future innovations and inspire the next generation of surgeons and scientists committed to transforming transplantation medicine.

Publications

  • Title: Future Therapy for End-Stage Kidney Failure: Gene-Edited Pig Kidney Xenotransplantation
    Authors: [Author(s) not shown]
    Year: 2025 (Review)

  • Title: International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation
    Authors: [Author(s) not shown]
    Year: 2025 (Review)

  • Title: Pilot Survey of Attitudes Toward Xenotransplantation Among Nursing Students in London, UK
    Authors: [Author(s) not shown]
    Year: 2025 (Article)

  • Title: Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease
    Authors: [Author(s) not shown]
    Year: 2025 (New England Journal of Medicine, Article)

  • Title: Inhibition of Inflammation by IL-6 Blockade in Xenotransplantation
    Authors: [Author(s) not shown]
    Year: 2025 (Review)

  • Title: Human CD55 Expression and C1 Inhibition Partially Protect Gene-Edited Pig Red Blood Cells From Human Complement-Mediated Hemolysis In Vitro
    Authors: [Author(s) not shown]
    Year: 2025 (Article)

  • Title: Anatomical and Physiological Considerations for Pig Cardiac Xenotransplantation
    Authors: [Author(s) not shown]
    Year: 2025 (Review)

  • Title: Impact of COVID-19 Vaccination and Infection on Anti-Triple-Knockout (TKO) Pig Antibody Production: A Study in Patients With End-Stage Liver Disease and Liver Transplant Recipients
    Authors: [Author(s) not shown]
    Year: 2025 (Article)

  • Title: Is There a Need for an Alternative Source of Red Blood Cells for Clinical Transfusion and Will Gene-Edited Pigs Fulfil That Need?
    Authors: [Author(s) not shown]
    Year: 2025 (Note)

  • Title: Treatment of Presumptive Rejection After Orthotopic Pig-to-Baboon Cardiac Xenotransplantation
    Authors: [Author(s) not shown]
    Year: 2025 (Article)

Conclusion

Dr. Cooper’s lifelong dedication to transplantation science has fundamentally reshaped the prospects of solving the organ shortage crisis through xenotransplantation. His discoveries laid the scientific foundation for the first gene-edited pig heart transplant into a human, a landmark achievement that reflects his enduring vision. Combining clinical excellence, scientific innovation, and academic leadership, he leaves a lasting legacy as both a pioneer and mentor. His career not only bridges past milestones with future possibilities but also ensures that transplantation medicine continues to advance toward transformative solutions for patients worldwide.

Rania Awadi | Developmental Neuroscience | Best Researcher Award

Published on by Neuroscientists

Dr. Rania Awadi | Developmental Neuroscience | Best Researcher Award

Dr. Rania Awadi |  Higher Institute of Medical Technologies of Tunis | Tunisia

Dr. Rania Awadi is a biophysics and medical imaging researcher whose work centers on cardiac biomechanics and non-invasive diagnostic techniques. With a PhD in biophysics and medical imaging, she has conducted advanced studies on left ventricle biomechanics using finite element modelling and gained international experience through research internships in France and collaborations with leading medical institutions in Tunisia. Her research expertise lies in cardiovascular MRI, image processing, and myocardial strain assessment, particularly in pediatric populations where diagnostic challenges are more pronounced. Among her significant contributions is a study on Duchenne Muscular Dystrophy, where she applied cardiac MRI feature tracking to identify early subclinical myocardial dysfunction without contrast agents, an advancement with meaningful clinical impact.

Profile

Google Scholar

Early Academic Pursuits

From the outset of her academic journey, Dr. Rania Awadi cultivated a strong foundation in biophysics, medical physics, and medical imaging. Her doctoral studies at the Higher Institute of Medical Technologies of Tunis were marked by a deep focus on the biomechanics of the left ventricle, where she applied finite element modelling to explore complex cardiac dynamics. Early research internships at prestigious institutions such as IMT Atlantique in France and Sorbonne University enriched her academic profile, enabling her to refine her expertise in advanced imaging and computational modelling techniques.

Professional Endeavors

Building upon her academic training, Dr. Awadi advanced into professional roles that merged teaching and research. She joined the Higher Institute of Medical Technologies of Tunis as a lecturer in biomechanics, where she has contributed to shaping future professionals in medical physics and imaging. Her work also extended to clinical collaborations, including her involvement with the Principal Military Hospital of Tunis and Monji Ben Hmida Center, emphasizing translational research that bridges scientific innovation with patient care.

Contributions and Research Focus

Dr. Awadi’s contributions to medical science are anchored in cardiovascular imaging and cardiac biomechanics. Her expertise lies in cardiac magnetic resonance imaging, image processing, and computational modelling, with a particular focus on assessing myocardial strain. She has addressed the unique challenges of pediatric populations, where smaller heart sizes, higher heart rates, and variability in strain demand precise methodologies. Her research has sought to make early diagnosis more accessible and reliable, especially in vulnerable groups affected by genetic and muscular disorders.

Pioneering Research on Duchenne Muscular Dystrophy

Among her notable achievements, Dr. Awadi conducted a pioneering study on myocardial strain assessment for early diagnosis of Duchenne Muscular Dystrophy in pediatric patients using cardiac MRI. Through the application of feature tracking techniques, she demonstrated the feasibility of detecting subclinical myocardial dysfunction without the use of contrast agents, reducing risks in younger patients. Her findings, published in Applied Sciences, underscored significant associations between myocardial strain parameters and structural cardiac changes, providing a non-invasive tool for monitoring disease progression in affected children.

Accolades and Recognition

Dr. Awadi’s scholarly contributions have been recognized in the international research community through publication in high-impact journals. Her work in Applied Sciences has strengthened her standing as an emerging researcher in cardiac imaging and biomechanics. Her collaborations with European and Tunisian research institutions reflect her growing reputation as a scientist capable of fostering cross-border innovation in medical imaging and biomechanics.

Impact and Influence

The impact of Dr. Awadi’s research extends beyond academic recognition to meaningful influence on clinical practices. By offering new insights into myocardial strain assessment, she has contributed to refining diagnostic approaches for conditions like Duchenne Muscular Dystrophy, where early intervention can significantly alter outcomes. Her teaching and mentorship also shape a new generation of researchers and clinicians, further amplifying the reach of her work across academia and healthcare.

Legacy and Future Contributions

Looking ahead, Dr. Awadi’s career continues to chart a path of scientific advancement and clinical relevance. With expertise spanning biomechanics, MRI, and computational modelling, she is poised to deepen investigations into cardiac function across diverse patient populations. Her future contributions are expected to expand the frontiers of non-invasive diagnostics, ensuring that her legacy in cardiovascular biomechanics and imaging is defined by both innovation and tangible impact on patient health.

Publications

Numerical study of two microwave antennas dedicated to superficial cancer hyperthermia
N. Benameur, R. Awadi, A. Bouabidi, M.A. Mohammed, M.U. Rehman, … – 2024

A quasi-static biomechanical model of the human myocardium based on Cardiac Magnetic Resonance images
R. Awadi, N. Benameur, T. Kraiem, L. Salam – 2023

Comparison of Left Ventricle Deformation Analysis Using Abaqus and CVi42 Software: Insights from Healthy Subjects and patients with Myocardial Infarction
R. Awadi, N. Benameur, A. Sleimi, L. Salam – 2025

Myocardial Strain Assessment for Early Duchenne Muscular Dystrophy Diagnosis in Pediatric Patients Using Cardiac MRI
R. Awadi, N. Benameur, H. Hafsi, T.B. Younes, Y. Arous, S. Labidi, … – 2024

Left Ventricle Wall Motion Abnormalities Detection in Cardiac MRI
N. Benameur, R. Awadi, R. Mahmoudi, M. Deriche, M. Al Betar – 2023

Finite Element of Biomechanical Model of the Human Myocardium from a Cardiac MRI Images
A. Rania, N. Benameur, T. Kraiem, S. Labidi – 2022

of the Human Myocardium from a Cardiac MRI Images
A. Rania, N. Benameur, T. Kraiem, S. Labidi – 2022

Conclusion

Dr. Awadi’s career reflects a blend of academic rigor, professional dedication, and innovative research that addresses pressing clinical needs in pediatric cardiology. Her work has advanced the understanding of myocardial strain assessment, offering tools that improve early diagnosis and patient care. Through her teaching, collaborations, and published research, she has established herself as a promising figure in cardiac imaging and biomechanics. Looking forward, her contributions are set to further bridge the gap between research and clinical application, reinforcing her role as a driving force in the development of non-invasive diagnostic technologies.

Patrick Vermersch | Multiple sclerosis | Best Researcher Award

Published on by Neuroscientists

Prof. Patrick Vermersch | Multiple Sclerosis | Best Researcher Award

Prof. Patrick Vermersch |  University of Lille |  France

Patrick Vermersch is a distinguished neurologist and academic leader whose career has been defined by groundbreaking contributions to the study and treatment of neurodegenerative diseases, particularly multiple sclerosis and Parkinson’s disease. His early academic research into Tau protein pathology opened new perspectives on Alzheimer’s and related conditions, while his later work at the University of Lille shaped innovative approaches to multiple sclerosis care through specialized units, biomarker research, and pioneering clinical trials. As Director of the Graduate School for Biology and Health, and through his leadership roles in international foundations, he has strengthened global collaboration, fostered next-generation researchers, and promoted patient-centered approaches to care.

Profiles

Orcid 
Scopus

Early Academic Pursuits

Patrick Vermersch began his academic journey deeply fascinated by the complexities of neurodegenerative diseases, directing much of his early research toward Alzheimer’s disease and related conditions. His work in the 1990s, alongside André Delacourte’s team, centered on the phosphorylation of Tau proteins, uncovering disease-specific patterns in conditions such as progressive supranuclear palsy and myotonic dystrophy. This pioneering exploration into Tau pathology not only shed light on abnormal protein distribution in aging but also led to the unexpected discovery of phosphorylated Tau proteins in the cortex of patients with Parkinson’s disease. These formative years established his scientific foundation and positioned him at the forefront of neurobiology research.

Professional Endeavors

At the University of Lille, Patrick Vermersch played a transformative role in expanding both research and clinical care in neurology. Early collaborations with experts in immunology, neuroradiology, and neurology fueled the establishment of a specialized care unit dedicated to patients with multiple sclerosis. His trajectory within the university evolved beyond laboratory work, encompassing administrative and academic leadership positions such as Vice-Dean for Research and Vice-President for Research in Biology and Health. Today, as Director of the Graduate School for Biology and Health, he continues to shape scientific progress by fostering innovation, mentoring students, and advancing institutional research strategies.

Contributions and Research Focus

Patrick Vermersch has been instrumental in multiple sclerosis research, making significant contributions to biomarkers, neuroinflammation, and disease-modifying treatments. His investigations into humoral immunity changes during the early phases of the disease marked an important breakthrough in understanding disease mechanisms. Over time, his research expanded toward treatment development, from symptomatic approaches to disease-modifying therapies. Currently, his work explores novel therapies such as Bruton’s Tyrosine Kinase inhibitors, masitinib, and CAR-T cell therapies, aiming to offer more personalized and effective treatment strategies for patients with progressive forms of multiple sclerosis. Parallel to this, his efforts extend to improving care for Parkinson’s disease, highlighting his broad commitment to advancing neurology.

Advancing Patient-Centered Research

A defining element of his career is the emphasis on patient-centered care. Through the creation of networks such as the Group for the Care and Study of Multiple Sclerosis, which later evolved into the PARCSeP network, Patrick Vermersch revolutionized the way patients are managed in northern France. By integrating multidisciplinary approaches and focusing on the global and multidimensional needs of patients, this initiative significantly improved treatment strategies and outcomes for individuals with both multiple sclerosis and Parkinson’s disease. His focus on patient-related outcomes continues to guide his research, emphasizing the personalization of treatment pathways through prognostic markers and early intensive therapies.

Accolades and Recognition

Patrick Vermersch’s influence extends far beyond his home institution. He has served as a board member of the European Charcot Foundation and co-founded the ParadigMS Foundation, both of which advance international collaboration in neurology research and education. His leadership within these organizations underscores his reputation as a respected authority in multiple sclerosis research and his ability to connect global expertise for collective progress. His recognition in the field reflects not only his scientific contributions but also his commitment to fostering collaboration and knowledge exchange.

Impact and Influence

The breadth of Patrick Vermersch’s work has left a profound mark on both the scientific community and patient care. From foundational discoveries in Tau protein pathology to clinical trial leadership on cutting-edge therapies for multiple sclerosis, his contributions have transformed the understanding and management of neurological diseases. His dedication to optimizing symptomatic treatment strategies, particularly in addressing fatigue and urinary disturbances, demonstrates his responsiveness to patient needs. By blending rigorous scientific research with a compassionate approach to healthcare, he has influenced both academic medicine and everyday clinical practice.

Legacy and Future Contributions

Looking ahead, Patrick Vermersch continues to drive innovation in neurology through his focus on precision medicine. The integration of early biomarkers, prognostic tools, and novel therapies promises to reshape how multiple sclerosis is diagnosed and treated. Ongoing clinical trials exploring therapies such as tolebrutinib and frexalimab signal a promising future for patients with progressive disease forms. His legacy lies not only in the scientific advancements he has spearheaded but also in the model of patient-centered care he has championed. As a mentor, researcher, and leader, he has laid a robust foundation that will continue to inspire future generations of neurologists and researchers dedicated to advancing human health.

Publications

Inhibiting CD40 Ligand in Multiple Sclerosis: A Review of Emerging Therapeutic Potential
Authors: Not specified
Year: 2025

Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression
Authors: Not specified
Year: 2025

Beyond the switch to the biosimilar of natalizumab: What is the impact of changing the JCV test?
Authors: Not specified
Year: 2025

Impact of Natalizumab on Productivity and Ability to Work in Patients with Multiple Sclerosis in France: The TITAN Study
Authors: Not specified
Year: 2025

Long-Term Management and Therapeutic Sequencing for Patients with Relapsing Multiple Sclerosis in France: A Vignette Study
Authors: Not specified
Year: 2025

Tolebrutinib in Nonrelapsing Secondary Progressive Multiple Sclerosis
Authors: Not specified
Year: 2025

Tyrosine kinase inhibitor, masitinib, limits neuronal damage, as measured by serum neurofilament light chain concentration in a model of neuroimmune-driven neurodegenerative disease
Authors: Not specified
Year: 2025

LymphoTEC: a Retrospective Real-World Study on Lymphocyte Reconstitution After Lymphopenia in Patients with Multiple Sclerosis Treated with Dimethyl Fumarate in France
Authors: Not specified
Year: 2025

Generics, Biosimilars and Follow-On Non-Biologic Complex Drugs for Multiple Sclerosis: A Narrative Review of the Regulatory and Clinical Implications for European Neurologists
Authors: Not specified
Year: 2025

Effect of siponimod on retinal thickness, a marker of neurodegeneration, in participants with SPMS: Findings from the EXPAND OCT substudy
Authors: Not specified
Year: 2025

Conclusion

Patrick Vermersch’s legacy lies at the intersection of scientific discovery, clinical innovation, and patient advocacy. His dedication to integrating research with real-world patient outcomes has not only advanced the understanding of neurodegenerative diseases but also transformed treatment paradigms to be more personalized and effective. With ongoing research into Bruton’s Tyrosine Kinase inhibitors, masitinib, and CAR-T cell therapies, his work continues to shape the future of neurology. His vision ensures that advances in science are consistently aligned with improving patient lives, making him a true trailblazer in modern neurological research and care.

Huiyan Li | Neuro-oncology | Best Researcher Award

Published on by Neuroscientists

Dr. Huiyan Li | Neuro-oncology | Best Researcher Award

Dr. Huiyan Li |  Fudan University | China

Huiyan Li, Ph.D., is a dedicated researcher whose academic journey spans pharmacy, biomedical engineering, tumor biology, and nanomedicine. Her doctoral studies focused on unraveling tumor resistance mechanisms and advancing biomarker detection technologies, while her postdoctoral work has pioneered the use of nanomedicine for cancer therapy, particularly in glioma treatment. She has made significant strides in understanding neurovascular and neuroimmune interactions in brain tumors, contributing to the development of nanoparticle-based therapies. In addition, her leadership in biomedical imaging has enhanced preclinical cancer research and facilitated the application of advanced imaging technologies. Li’s interdisciplinary expertise positions her at the forefront of translational oncology research, bridging fundamental science with innovative therapeutic strategies.

Profile

Google Scholar

Early Academic Pursuits

From the outset of her academic journey, Huiyan Li cultivated a deep interest in the intersection of pharmacy, biomedical engineering, and tumor biology. Her undergraduate studies in pharmacy provided a solid grounding in drug formulation and absorption mechanisms, which she later expanded through her master’s research in biomedical engineering. There, she explored innovative tissue engineering strategies, focusing on nano-polymer-based therapeutics for vascular repair in ischemic tissues. This multidisciplinary foundation prepared her to pursue advanced research in medical sciences, where her doctoral work centered on tumor biology, resistance mechanisms, and biomarker detection.

Doctoral Research in Tumor Biology

During her doctoral training at a leading medical institution, Li concentrated on unraveling the biological mechanisms underlying drug resistance in tumors. She explored the complex signaling pathways, with a particular emphasis on Hedgehog-mediated resistance in tumor models. Alongside these mechanistic studies, she pioneered the development of a novel aptasensor-based assay capable of highly sensitive detection of tumor biomarkers. This innovative work not only provided insights into therapeutic resistance but also advanced precision diagnostics in oncology.

Advancements in Nanomedicine

Following her doctoral studies, Li expanded her expertise into the field of nanomedicine, dedicating her postdoctoral research to the development of iron- and ferritin-based nanomedicines. Her investigations revealed how nanomedicines could exploit biological processes such as organelle cross-talk and oxidative stress to induce tumor cell apoptosis. She also explored strategies to disrupt compensatory mechanisms between selenoproteins, enhancing the therapeutic potential of nanomedicine platforms. These findings have contributed significantly to the broader field of nanobiomedicine, establishing new avenues for tumor-targeted therapy.

Research in Neuro-oncology

Building upon her prior expertise, Li directed her attention to the challenging domain of neuro-oncology. She investigated the mechanisms by which nanoparticles penetrate gliomas and other central nervous system tumors, with a focus on identifying endothelial cell subpopulations that regulate nanoparticle entry. Her work also examined the communication between tumor-associated endothelial cells and immune cells, shedding light on neurovascular and neuroimmune interactions in glioblastoma. This pioneering research represents an important step toward improving nanoparticle-based therapies for brain tumors, which remain among the most difficult cancers to treat.

Contributions to Imaging and Biomedical Technologies

Alongside her research in tumor biology and nanomedicine, Li made significant contributions to biomedical imaging. Serving as a technical director for a small animal live imaging core facility, she became proficient in advanced modalities such as live optical and MicroCT imaging. She applied these tools to monitor tumor development and therapeutic responses in vivo, thereby enhancing preclinical models of neuro-oncology. Her commitment to training and knowledge-sharing ensured that imaging technologies could be widely utilized to accelerate translational cancer research.

Recognition and Emerging Influence

Throughout her career, Li’s dedication to bridging basic science with clinical application has earned recognition within the scientific community. Her cross-disciplinary expertise—spanning pharmacy, biomedical engineering, tumor biology, nanomedicine, and neuro-oncology—has positioned her as an emerging leader in the development of precision therapies for cancer. By integrating advanced imaging, molecular biology, and nanotechnology, she has established a reputation for innovation in the fight against treatment resistance and tumor progression.

Legacy and Future Contributions

Looking ahead, Li’s research promises to make a lasting impact on the fields of nanomedicine and neuro-oncology. Her work is poised to redefine how nanoparticle platforms can be tailored to overcome barriers in the central nervous system, offering new hope for patients with glioblastoma and other brain tumors. By combining mechanistic insights with translational strategies, she is advancing toward a future where cancer therapy becomes more effective, targeted, and personalized. Her legacy will be one of integrating science and technology to push the boundaries of cancer treatment and improve patient outcomes worldwide.

Publications

A forward vision for chemodynamic therapy: issues and opportunities
P Zhao, H Li, W Bu — 2023

Advances in detection of infectious agents by aptamer-based technologies
HY Li, WN Jia, XY Li, L Zhang, C Liu, J Wu — 2020

Immunotherapy for advanced hepatocellular carcinoma, where are we?
L Zhang, J Ding, HY Li, ZH Wang, J Wu — 2020

Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery
J Guan, ZQ Zhou, MH Chen, HY Li, DN Tong, J Yang, J Yao, ZY Zhang — 2017

ZIF‐based nanoparticles combine X‐ray‐induced nitrosative stress with autophagy management for hypoxic prostate cancer therapy
Y Li, T Gong, H Gao, Y Chen, H Li, P Zhao, Y Jiang, K Wang, Y Wu, … — 2021

Thermo-responsive polymer encapsulated gold nanorods for single continuous wave laser-induced photodynamic/photothermal tumour therapy
B Gong, Y Shen, H Li, X Li, X Huan, J Zhou, Y Chen, J Wu, W Li — 2021

Heterostructures with built‐in electric fields for long‐lasting chemodynamic therapy
H Zhang, Y Chen, W Hua, W Gu, H Zhuang, H Li, X Jiang, Y Mao, Y Liu, … — 2023

Hedgehog signaling, a critical pathway governing the development and progression of hepatocellular carcinoma
J Ding, HY Li, L Zhang, Y Zhou, J Wu — 2021

Polyamine-activated carbonyl stress strategy for oxidative damage therapy
K Wang, J Li, Y Yi, B Lv, Y Wu, C Wang, H Li, Y Li, Y Liu, X Cai, X Meng, … — 2022

Hedgehog signalling mediates drug resistance through targeting TAP1 in hepatocellular carcinoma
XT Zhou, J Ding, HY Li, JL Zuo, SY Ge, HL Jia, J Wu — 2020

Blocking spatiotemporal crosstalk between subcellular organelles for enhancing anticancer therapy with nanointercepters
H Li, H Zhang, X He, P Zhao, T Wu, J Xiahou, Y Wu, Y Liu, Y Chen, … — 2023

Nutrient-delivery and metabolism reactivation therapy for melanoma
Y Chen, C Wang, Y Wu, Y Wang, Y Meng, F Wu, H Zhang, YY Cheng, … — 2024

Novel aptasensor-based assay of sonic hedgehog ligand for detection of portal vein invasion of hepatocellular carcinoma
HY Li, FF Yin, XY Li, WN Jia, J Ding, L Zhang, ZH Wang, QQ Hu, JL Zuo, … — 2021

Conclusion

Through her integration of nanomedicine, neuro-oncology, and advanced imaging, Huiyan Li has established herself as an emerging leader in cancer research. Her contributions address some of the most complex challenges in oncology, particularly treatment resistance and central nervous system tumor targeting. With her innovative approach and commitment to translational impact, she is poised to shape the future of precision medicine in neuro-oncology. Her work stands as a testament to the transformative potential of interdisciplinary research in advancing cancer therapy and improving patient outcomes.