Mohamad-Reza Aghanoori | Neurodegenerative Disorders | Best Researcher Award

Posted on by Neuroscientists

Dr. Mohamad-Reza Aghanoori | Neurodegenerative Disorders | Best Researcher Award

Dr. Mohamad-Reza Aghanoori, National Institute of Genetic Engineering and Biotechnology,  Iran.

Dr. Mohamad-Reza Aghanouri is a distinguished neuroscientist and molecular medicine expert whose academic journey spans Iran and Canada. Beginning with foundational training in genetics and human biology, he has advanced into a dynamic career focused on translational neuroscience, particularly the genetic regulation of neurodevelopmental and neurodegenerative disorders. His doctoral and postdoctoral research have contributed significant insights into insulin/IGF-1 signaling, mitochondrial function, and gene expression related to autism and diabetic neuropathy.

Profile

Google Scholar

🎓 Early Academic Pursuits

Mohamad-Reza Aghanouri embarked on his academic journey with a B.Sc. in Cellular and Molecular Biology–Genetics from Shahid Chamran University of Ahvaz, Iran, in 2009. His keen interest in the intricate mechanics of human biology led him to pursue an M.Sc. in Human Genetics at Shiraz University of Medical Sciences, where he explored non-invasive techniques for early sex determination through free fetal DNA analysis. His growing passion for neuroscience and genetics culminated in a Ph.D. from the University of Manitoba, Canada, where he studied at the Department of Pharmacology and Therapeutics and the Division of Neurodegenerative Disorders. His doctoral thesis, focused on insulin/IGF-1 regulation of mitochondrial function in diabetic neuropathy, laid a strong foundation for a dynamic career in translational neurogenetics.

🧬 Professional Endeavors in Translational Neuroscience

Dr. Aghanouri’s postdoctoral work reflects a robust engagement with translational neuroscience and molecular medicine. From 2019 to 2024, he served as a postdoctoral fellow at the Department of Medical Genetics, Cumming School of Medicine, University of Calgary, under the mentorship of Dr. Guang Yang. His research investigated translational regulation of genes implicated in brain development, especially in autism spectrum disorders and rare neurodevelopmental conditions. Prior to that, he worked with Prof. Paul Fernyhough in Winnipeg, Canada, where he examined the role of IGF-1 in ATP production in sensory neurons under diabetic stress conditions. His diverse experience also includes a pivotal R&D advisory role at Roya Bio Gene Company in Tehran, showcasing his versatility across both academic and industrial biosciences.

🔬 Contributions and Research Focus

Dr. Aghanouri’s research contributions bridge the realms of neurodevelopment, metabolism, and genetic regulation. He has delved into the complex interplay between growth factors like IGF-1 and mitochondrial dynamics, particularly in relation to diabetic neuropathy. At the University of Calgary, his postdoctoral investigations explored the molecular pathways influencing neurodevelopmental disorders, positioning his work at the intersection of genomics and neuroscience. His methodological expertise spans cellular models, gene expression analysis, and translational bioinformatics, underscoring a commitment to discovering mechanisms that translate molecular findings into therapeutic insights.

🏆 Accolades and Recognition

Over the course of his academic and research career, Dr. Aghanouri has amassed a commendable list of honors. He received the prestigious CIHR postdoctoral fellowship (CA$40,000 annually, plus research allowance), along with additional fellowships from the Alberta Children’s Hospital Research Institute and the Cumming School of Medicine. Notably, he clinched first place in the Striking Image Competition at the University of Calgary and was honored by the BoniadMelliNokhbegan Foundation for his exceptional research talent. He has also earned multiple research grants from Iranian institutions in 2023 and 2024, reflecting his cross-border research impact and trust among funding bodies.

📚 Institutional Leadership and Influence

In 2024, Dr. Aghanouri was appointed as the Head of the Library, Documentation, Scientometrics, and Publication Center at the National Institute of Genetic Engineering and Biotechnology (NIGEB) in Tehran. He also holds a faculty position in the Department of Molecular Medicine at NIGEB. These roles position him as a key academic leader in Iran’s scientific community, where he not only continues his research but also shapes institutional research strategies, publication ethics, and scientific communication infrastructures. His work contributes significantly to Iran’s national bioscience and health research priorities.

🌍 Impact and Global Engagement

With academic roots in Iran and a decade of research training in Canada, Dr. Aghanouri exemplifies international scientific collaboration. His work addresses global health concerns, such as diabetes-induced neuropathies and neurodevelopmental disorders like autism, thus resonating with both clinical and scientific audiences worldwide. Through his active participation in conferences, poster competitions, and collaborative projects, he serves as a bridge between Iranian biotechnology advancements and the international research community.

🔮 Legacy and Future Contributions

Looking ahead, Dr. Aghanouri is poised to further advance the fields of molecular neurogenetics and translational medicine. His ongoing research is expected to uncover novel genetic mechanisms underlying brain development and metabolic dysfunctions. As a faculty member and research leader, he is mentoring the next generation of Iranian scientists while enhancing the global understanding of complex neurological diseases. His integrated approach to research, policy, and education ensures that his legacy will be one of both scientific innovation and institutional transformation.

Publication

 

  • Betulin and its derivatives as novel compounds with different pharmacological effects
    S Amiri, S Dastghaib, M Ahmadi, P Mehrbod, F Khadem, H Behrouj, …
    2020

 

  • Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury
    A Stamenkovic, KA O’Hara, DC Nelson, TG Maddaford, AL Edel, …
    2021

 

  • Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes
    MR Aghanoori, DR Smith, S Shariati-Ievari, A Ajisebutu, A Nguyen, …
    2019

 

  • The ER stress/UPR axis in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
    M Aghaei, S Dastghaib, S Aftabi, MR Aghanoori, J Alizadeh, P Mokarram, …
    2020

 

  • MiRNA molecular profiles in human medical conditions: Connecting lung cancer and lung development phenomena
    MR Aghanoori, B Mirzaei, M Tavallaei
    2014

 

  • Mechanisms targeting the unfolded protein response in asthma
    S Dastghaib, PS Kumar, S Aftabi, G Damera, A Dalvand, A Sepanjnia, …
    2021

 

  • Nucleocytoplasmic transport of the RNA-binding protein CELF2 regulates neural stem cell fates
    MJ MacPherson, SL Erickson, D Kopp, P Wen, MR Aghanoori, S Kedia, …
    2021

 

  • CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E1*3 Allele Frequencies in Iranian Populations
    GM Shahriary, H Galehdari, A Jalali, F Zanganeh, SMR Alavi, …
    2012

 

  • Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats
    MR Aghanoori, DR Smith, SR Chowdhury, MG Sabbir, NA Calcutt, …
    2017

 

  • CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth
    MR Aghanoori, P Agarwal, E Gauvin, RS Nagalingam, R Bonomo, …
    2022

✅ Conclusion

Dr. Aghanouri stands out as a versatile and impactful scientist whose contributions to neuroscience and genetic medicine hold promise for both understanding and treating complex neurological conditions. His career reflects a strong blend of academic excellence, international collaboration, and leadership in research development. As he continues to build bridges between Iranian and global biosciences, his future work is expected to leave a lasting legacy in molecular neuroscience and translational medicine.

 

Toru Yoshiura | Clinical Neuroscience | Neuroscience Research Excellence Award

Posted on by Neuroscientists

Dr. Toru Yoshiura | Clinical Neuroscience | Neuroscience Research Excellence Award

Dr. Toru Yoshiura,  National Defense Medical College, Japan.

Dr. Toru Yoshiura, a Lieutenant Commander in the Japan Maritime Self-Defense Force (JMSDF) and a board-certified neurosurgeon, has cultivated a remarkable career blending military service, clinical excellence, and academic research. A graduate of the National Defense Medical College, he has pursued specialized training in diving medicine and neuroendoscopic surgery while serving in key clinical and field deployments, including anti-piracy missions. His research focuses on innovative neuroprotective strategies for subarachnoid hemorrhage, and he actively contributes to the education of future neurosurgeons through specialized anatomical dissection courses. Dr. Yoshiura holds multiple national certifications and is an active member of prominent neurosurgical societies, where he plays a leadership role in advancing young professionals.

Profile

Orcid

🎓 Early Academic Pursuits

Born on January 15, 1987, in Hiroshima, Japan, Dr. Toru Yoshiura began his distinguished journey in medicine with a solid academic foundation at the National Defense Medical College, where he pursued his studies from April 2005 to March 2011. During these formative years, he developed a strong inclination toward the intricate world of neurosurgery. His academic journey was not limited to conventional study; he also completed rigorous military medical training at the JMSDF Officer Candidate School in 2011 and the Diving Medical Officer’s Course in 2013. Driven by both curiosity and commitment, Dr. Yoshiura later pursued graduate studies in medicine at the same institution, where he currently investigates novel therapeutic strategies in neurosurgical conditions, particularly focusing on cerebral ischemia models.

⚓ Professional Endeavors

Dr. Yoshiura’s career seamlessly blends clinical excellence with military service. Since 2011, he has been a commissioned officer in the Japan Maritime Self-Defense Force (JMSDF), rising to the rank of Lieutenant Commander. His professional journey commenced with a clinical residency at the National Defense Medical College Hospital, followed by a tenure as a neurosurgeon at JSDF Yokosuka Hospital, where he also took part in the 17th Deployment Surface Force Counter Piracy Enforcement in 2013–2014. Subsequent assignments included advanced clinical residency, service at the JSDF Central Hospital, and another deployment during the 37th Counter Piracy Enforcement (2020–2021). Currently, he practices at the National Defense Medical College Hospital, where he brings both his clinical and research expertise to the forefront.

🧠 Contributions and Research Focus

Dr. Yoshiura has emerged as a dedicated researcher with a keen interest in neuroprotection and neurovascular recovery. His ongoing doctoral research explores the synergistic effects of hydrogen inhalation and intrathecal magnesium sulfate treatment in enhancing ischemic outcomes without suppressing cortical spreading depolarization—work that promises to revolutionize the management of subarachnoid hemorrhage (SAH). Moreover, he serves as the Course Director of the White Matter Dissection Course, a specialized program aimed at enhancing neurosurgical anatomical understanding, further showcasing his commitment to academic mentorship and the future of neurosurgical training.

🏅 Accolades and Recognition

Dr. Yoshiura’s dedication to excellence has been officially recognized through multiple prestigious medical certifications in Japan. He holds certifications from the Japanese Boards of Neurosurgery, Stroke, Neuroendovascular Therapy, and Neurotraumatology, and he is also a qualified Neuroendoscopic Surgeon. His credentials reflect a consistent track record of advanced surgical training and expertise across a spectrum of subspecialties, reinforcing his status as a versatile and trusted neurosurgeon in both military and civilian healthcare settings.

🌐 Impact and Influence

Beyond operating rooms and laboratories, Dr. Yoshiura has made meaningful contributions to the broader medical and scientific community through active engagement with multiple professional organizations. He is a core member of the Under 40 Committee of the Japanese Congress for Brain Tumor Surgery, signifying his leadership among emerging neurosurgeons. His involvement spans a wide array of societies, including the Japan Neurosurgical Society, Japanese Society on Surgery for Cerebral Stroke, and Japan Society for Neuro-Oncology, among others. This multi-society participation not only amplifies his influence but also allows him to remain at the cutting edge of developments in neurosurgical practice and policy.

🌍 Service Beyond Borders

Dr. Yoshiura’s compassion and sense of duty extend beyond his professional obligations. In 2010, he volunteered at a kindergarten in Bari, Indonesia, demonstrating his humanitarian spirit and willingness to serve communities in need. This formative experience abroad may have enriched his global outlook on medicine and underscored the human side of healthcare—a trait that continues to inform his interactions with patients and peers alike.

🚀 Legacy and Future Contributions

As a rising leader in neurosurgery within the military-medical sphere, Dr. Yoshiura’s legacy is already being defined by a synthesis of cutting-edge research, exceptional surgical practice, and dedicated mentorship. With his ongoing doctoral work poised to make significant contributions to the treatment of ischemic brain injuries, and his involvement in advanced neurosurgical education, he is set to influence both clinical practices and the next generation of neurosurgeons. His unique integration of military precision and academic rigor ensures that his future contributions will be both impactful and enduring.

Publication

  1. Title: Carotid Endarterectomy with Twisted Internal Jugular Vein Located Anterior to the Common Carotid Artery
    Authors: Arumu Endo, Terushige Toyooka, Kazuya Fujii, Satoru Takeuchi, Toru Yoshiura, Masaya Nakagawa, Yohei Otsuka, Arata Tomiyama, Kojiro Wada
    Year: 2025

 

  1. Title: Effectiveness of Keyhole Clipping of Unruptured Intracranial Aneurysms Detected by “Brain Dock” in Healthy Japanese Adults
    Authors: Toru Yoshiura, Satoru Takeuchi, Terushige Toyooka, Arata Tomiyama, Kojiro Wada, Yasuaki Nakao, Takuji Yamamoto, Kentaro Mori, toruyukiko
    Year: 2023

 

  1. Title: KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway
    Authors: Takashi Fujii, Yoshiko Nakano, Daichi Hagita, Nobuyuki Onishi, Arumu Endo, Masaya Nakagawa, Toru Yoshiura, Yohei Otsuka, Satoru Takeuchi, Mario Suzuki et al.
    Year: 2023

 

  1. Title: Surgical Rescue Technique for Incomplete Burr Hole Using a Small Bone Piece and the Craniotome
    Authors: Toru Yoshiura, Kojiro Wada, Kosuke Kumagai, Satoru Takeuchi, Terushige Toyooka, Otani, Kentaro Mori
    Year: 2019

🔚 Conclusion

Dr. Yoshiura’s journey exemplifies a rare integration of surgical mastery, military discipline, and scientific innovation. His commitment to advancing the field of neurosurgery—through both cutting-edge research and hands-on mentorship—positions him as a future leader in academic and military medicine alike. With a career rooted in service, science, and skill, Dr. Yoshiura is not only shaping current practices but also building a lasting legacy for future generations of neurosurgeons in Japan and beyond.