Magdalena Budzyń | Immunology | Women Researcher Award

Assist. Prof. Dr. Magdalena Budzyń | Immunology | Women Researcher Award

Assist. Prof. Dr. Magdalena Budzyń, Poznan University of Medical Sciences, Poland.

Dr. Magdalena Budzyń is an accomplished researcher and educator specializing in cardiovascular diseases and laboratory diagnostics. With a strong academic foundation from Poznan University of Medical Sciences, she earned her Ph.D. in Medical Sciences and later achieved the prestigious habilitated doctor qualification. Her research focuses on endothelial damage markers and their role in cardiovascular conditions, contributing valuable insights into disease mechanisms. As an Assistant Professor, she has been dedicated to both scientific discovery and mentoring future medical professionals.

Profile

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Early Academic Pursuits 🎓

Born on April 4, 1982, Dr. Magdalena Budzyń embarked on her academic journey with a passion for medical sciences. Her educational path began at Poznan University of Medical Sciences, where she pursued an in-depth study of laboratory diagnostics. She completed her Ph.D. in Medical Sciences between 2009 and 2013, focusing on the intricate balance between leukocyte elastase and its inhibitor alpha1-antitrypsin in chronic venous insufficiency. With an insatiable curiosity for cardiovascular research, she further advanced her academic credentials by earning a habilitated doctor degree in 2022, exploring circulating markers of endothelial damage and their clinical implications in cardiovascular diseases.

Professional Endeavors 🏅

Dr. Budzyń’s professional career has been a testament to her dedication to medical research and education. She has been an integral part of Poznan University of Medical Sciences since 2007, serving as an Assistant Professor. Prior to that, she gained valuable experience at Poznan Veterinary Institute as a Technical Assistant, where she honed her laboratory and analytical skills. Her expertise in laboratory medicine and medical chemistry has made her a respected academic in her field, contributing significantly to both research and teaching.

Contributions and Research Focus 🔬

Her research primarily revolves around cardiovascular diseases, with a particular emphasis on endothelial damage markers. By investigating the role of these biomarkers, she has provided critical insights into the pathophysiology of vascular disorders. Her work has contributed to the understanding of chronic venous insufficiency and how leukocyte elastase imbalance impacts disease progression. Additionally, her studies in laboratory diagnostics have strengthened the role of clinical biomarkers in predicting and managing cardiovascular conditions.

Accolades and Recognition 🏆

Dr. Budzyń’s academic excellence has been recognized through her habilitated doctor qualification, a prestigious milestone in her career. Her contributions to medical sciences have been acknowledged within the scientific community, as she continues to shape the field of cardiovascular research. Her role as an educator and mentor further amplifies her influence, guiding students toward meaningful research endeavors in laboratory medicine and diagnostics.

Impact and Influence 🌍

Beyond academia, Dr. Budzyń’s research has a profound impact on the medical field, particularly in improving diagnostic tools for cardiovascular diseases. Her findings contribute to enhanced patient care by identifying key biomarkers that aid in early disease detection and treatment planning. She actively collaborates with researchers and medical professionals, ensuring that her work bridges the gap between scientific discovery and clinical application.

publication

  • Significance of the monocyte CCR2-CCL2 axis in triple-negative breast cancer
    Authors: Magdalena Budzyń, Agata Kubicka, Elżbieta Kaja, Witold Kycler, Joanna Załuska-Kusz, Jacek J. Brzeziński, Marcelina Sperling, Alicja Bukowska, Joanna Grupińska
    Year: 2025

 

  • Nutritional Behaviors, Vitamin Supplementation and Physical Activity among Polish Adults during the COVID-19 Pandemic
    Authors: Bogna Gryszczyńska, Magdalena Budzyń, Joanna Grupińska, Magdalena Paulina Kasprzak, Agnieszka Gryszczyńska
    Year: 2022

 

  • Beneficial Effects of Oral Nutritional Supplements on Body Composition and Biochemical Parameters in Women with Breast Cancer Undergoing Postoperative Chemotherapy: A Propensity Score Matching Analysis
    Authors: Joanna Grupińska, Magdalena Budzyń, Kalina Maćkowiak, Jacek Jakub Brzeziński, Witold Kycler, Ewa Leporowska, Bogna Gryszczyńska, Magdalena Paulina Kasprzak, Maria Iskra, Dorota Formanowicz
    Year: 2021

 

  • Association between clinicopathological features of breast cancer with adipocytokine levels and oxidative stress markers before and after chemotherapy
    Authors: Magdalena Budzyń
    Year: 2021

 

  • Changes in the Nrf2/Keap1 Ratio and PON1 Concentration in Plasma of Patients Undergoing the Left Main Coronary Artery Stenting
    Authors: Magdalena Budzyń
    Year: 2020

 

  • Selected Atherosclerosis-Related Diseases May Differentially Affect the Relationship between Plasma Advanced Glycation End Products, Receptor sRAGE, and Uric Acid
    Authors: Bogna Gryszczyńska, Magdalena Budzyń, Dorota Formanowicz, Maria Wanic-Kossowska, Piotr Formanowicz, Wacław Majewski, Maria Iskra, Magdalena P. Kasprzak
    Year: 2020

 

  • Association between Advanced Glycation End Products, Soluble RAGE Receptor, and Endothelium Dysfunction, Evaluated by Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Mild and Resistant Hypertension
    Authors: Magdalena Budzyń
    Year: 2019

 

  • The Potential Role of Circulating Endothelial Cells and Endothelial Progenitor Cells in the Prediction of Left Ventricular Hypertrophy in Hypertensive Patients
    Authors: Magdalena Budzyń
    Year: 2019

 

  • Advanced Oxidation Protein Products and Carbonylated Proteins Levels in Endovascular and Open Repair of an Abdominal Aortic Aneurysm: The Effect of Pre-, Intra-, and Postoperative Treatment
    Authors: Bogna Gryszczyńska, Magdalena Budzyń, Dorota Formanowicz, Piotr Formanowicz, Zbigniew Krasiński, Natalia Majewska, Maria Iskra, Magdalena P. Kasprzak
    Year: 2019

 

Conclusion

Dr. Budzyń’s contributions to medical sciences extend beyond academia, influencing the fields of laboratory diagnostics and cardiovascular research. Her work has significantly improved the understanding of endothelial dysfunction and biomarker-based diagnostics, paving the way for better clinical applications. With her ongoing dedication to research and education, she continues to inspire the next generation of scientists while striving to make impactful advancements in medical science.

Bastian Höchst | Onco- Immunology | Best Researcher Award

Dr. Bastian Höchst | Onco- Immunology | Best Researcher Award

Dr. Bastian Höchst,  Institute of Molecular Immunology, MRI, TUM, Germany.

Bastian Höchst is a distinguished molecular immunologist whose career spans groundbreaking research, impactful teaching, and valuable contributions to the scientific community. His academic journey began with a focus on biology and culminated in a doctorate on immune regulation in liver tumors. As a Research Group Leader at the Technical University of Munich, he investigates the complex interplay of immune cells and tissues in acute and chronic inflammation. His pioneering discoveries, such as the mechanisms governing myeloid suppressor cells and immune-regulatory metabolite transfer, have advanced understanding in the field.

Profile

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🌱 Early Academic Pursuits

Bastian Höchst began his academic journey with a passion for understanding the intricate mechanisms of biology. From 1999 to 2005, he pursued his studies in Biology at the University of Bonn and Hamburg, laying the foundation for his future endeavors in molecular immunology. His academic curiosity led him to pursue a doctorate at the Medical School Hannover under the guidance of Prof. Dr. Tim F. Greten. His doctoral research focused on identifying and characterizing myeloid-derived suppressor cells in patients with hepatocellular carcinoma, marking the beginning of his impactful contributions to the field of immunology.

🔬 Professional Endeavors

Currently serving as a Research Group Leader at the Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University of Munich (TUM), Bastian Höchst has dedicated his career to unraveling the complexities of immune regulation. His journey in academia has been marked by significant roles, including his previous tenure as a Research Group Leader at the Institute for Animal Physiology and Immunology, Wissenschaftszentrum Weihenstephan, TUM. Additionally, his postdoctoral fellowship at the Institute of Molecular Medicine and Experimental Immunology at the University of Bonn further honed his expertise in immune mechanisms.

🧪 Contributions and Research Focus

Bastian Höchst’s research delves into immune regulation within acute and chronic inflammatory processes, with a particular focus on tissue-specific mechanisms. He has made groundbreaking discoveries, including elucidating the pathways that govern the generation of myeloid suppressor cells in liver tumors. Furthermore, his innovative work revealed that the intercellular transfer of immune-regulatory metabolites is critical to T-cell effector functions. His research has significantly advanced the understanding of immune responses in disease contexts, bridging gaps in immunological knowledge.

🎓 Teaching and Mentorship

A dedicated educator, Bastian Höchst has been actively involved in teaching since 2010, inspiring students in life sciences programs at TUM. His lectures on topics such as onco-immunology, immune metabolism, and immunotherapy provide invaluable insights to aspiring scientists. Through lab courses on immune cell phenotyping and advanced techniques like spectral flow cytometry, he has empowered students with the skills to explore the complexities of immunology. His teaching contributions extend beyond knowledge dissemination, fostering a generation of critical thinkers and innovators.

📜 Accolades and Recognition

Bastian’s expertise has been recognized through his habilitation and venia legendi for Molecular Immunology, under the mentorship of Prof. Dr. Percy Knolle. His contributions as a scientific reviewer for prestigious journals like Hepatology, Journal of Hepatology, and Frontiers in Immunology further reflect his authority in the field. Additionally, his role in evaluating grant applications for the Deutsche Forschungsgemeinschaft (DFG) underscores his impact on shaping future research initiatives.

🌍 Impact and Influence

Through his research, teaching, and reviews, Bastian Höchst has left an indelible mark on the field of molecular immunology. His work not only uncovers critical mechanisms of immune regulation but also provides pathways for therapeutic advancements in inflammatory and tumor-related conditions. His contributions influence both scientific understanding and practical applications, addressing global challenges in health and disease management.

🌟 Legacy and Future Contributions

Bastian Höchst’s journey is one of passion, discovery, and impact. As he continues to lead groundbreaking research, he sets the stage for a future where immune-based therapies are revolutionized. His legacy lies in his ability to connect fundamental research with real-world applications, inspiring colleagues and mentees alike. With his unwavering commitment to scientific exploration, Bastian Höchst is poised to shape the future of molecular immunology, paving the way for transformative breakthroughs.

Publication

  • A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4+ CD25+ Foxp3+ T cells
    Authors: B. Höchst, L.A. Ormandy, M. Ballmaier, F. Lehner, C. Krüger, M.P. Manns, …
    Year: 2008

 

  • Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
    Authors: B. Höchst, T. Voigtlaender, L. Ormandy, J. Gamrekelashvili, F. Zhao, …
    Year: 2009

 

  • Functional classification of memory CD8+ T cells by CX3CR1 expression
    Authors: J.P. Böttcher, M. Beyer, F. Meissner, Z. Abdullah, J. Sander, B. Höchst, …
    Year: 2015

 

  • Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells
    Authors: B. Höchst, J. Gamrekelashvili, M.P. Manns, T.F. Greten, F. Korangy
    Year: 2011

 

  • S100A9 a new marker for monocytic human myeloid‐derived suppressor cells
    Authors: F. Zhao, B. Höchst, A. Duffy, J. Gamrekelashvili, S. Fioravanti, M.P. Manns, …
    Year: 2012

 

  • Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal
    Authors: T. Baumann, A. Dunkel, C. Schmid, S. Schmitt, M. Hiltensperger, K. Lohr, …
    Year: 2020

 

  • Kupffer cell-derived Tnf triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS
    Authors: D. Yuan, S. Huang, E. Berger, L. Liu, N. Gross, F. Heinzmann, M. Ringelhan, …
    Year: 2017

 

  • Low-dose cyclophosphamide treatment impairs regulatory T cells and unmasks AFP-specific CD4+ T-cell responses in patients with advanced HCC
    Authors: T.F. Greten, L.A. Ormandy, A. Fikuart, B. Höchst, S. Henschen, M. Hörning, …
    Year: 2010

 

Conclusion

Bastian Höchst’s career exemplifies dedication to advancing molecular immunology through innovative research, education, and mentorship. His contributions have shaped the understanding of immune responses in disease contexts, offering hope for novel therapeutic approaches. As he continues to lead impactful research and foster new talent, Bastian Höchst remains a visionary in his field, poised to drive future breakthroughs that bridge science and medicine for the benefit of society.