Lin Jizhen | Cancer immunotherapy | Best Researcher Award

Posted on by sciencefather

Prof. Lin Jizhen | Cancer immunotherapy | Best Researcher Award

Prof.  Lin Jizhen, Union Hospital, Fujian Medical University, China.

Dr. Jizhen Lin is a distinguished physician-scientist whose career has been defined by an unwavering dedication to the field of auditory molecular biology. With his foundational medical education from Fujian Medical University and advanced research training in biochemistry and molecular biology at the University of Minnesota, he has seamlessly blended clinical acumen with scientific innovation. His professional roles have evolved from intern and research fellow to Associate Professor and Laboratory Director, reflecting a career rich in mentorship, discovery, and leadership. His research has focused extensively on otitis media and the molecular mechanisms of hearing, contributing valuable insights into the pathophysiology and potential treatments of auditory disorders.

Profile

Scopus

 

📚 Early Academic Pursuits

Dr. Jizhen Lin’s academic journey began with a strong foundation in medicine at Fujian Medical University, Fuzhou, China, where he earned his M.D. in 1982 and an M.S. in Otolaryngology in 1987. His thirst for advanced knowledge and scientific discovery later brought him to the University of Minnesota, Minneapolis, where he immersed himself in the fields of biochemistry and molecular biology, further enriching his expertise and setting the stage for a robust research career in auditory sciences.

🧪 Professional Endeavors

Dr. Lin’s professional path has been marked by consistent dedication and a progressive climb through academic and research positions. His early clinical exposure as an intern at Union Hospital in Fujian laid the groundwork for his subsequent transition into research. Between 1992 and 1995, he served as an International Research Fellow at the Otitis Media Research Center (OMRC), University of Minnesota. He continued to make strides as a Research Scientist and Co-director of the Otopathology-Molecular Biology Laboratory, contributing significantly to auditory molecular biology. His leadership abilities culminated in his appointment as Director of the Auditory Molecular Biology Laboratory, and he has been serving as an Associate Professor in the Department of Otolaryngology at the University of Minnesota Medical School since 2008.

🔬 Contributions and Research Focus

Throughout his career, Dr. Lin has concentrated on unraveling the complexities of auditory molecular biology with a primary focus on otitis media, a prevalent childhood disease. His contributions have been instrumental in bridging clinical otolaryngology with molecular science, employing biochemical tools to investigate the pathogenesis of auditory disorders. His laboratory has played a critical role in advancing understanding of the genetic and cellular mechanisms that underpin hearing loss and middle ear infections, particularly through innovative translational approaches.

🏅 Accolades and Recognition

Dr. Lin’s relentless pursuit of scientific excellence and impactful research has earned him widespread recognition in the field of otolaryngology. His tenure as a Graduate Faculty advisor reflects not only his dedication to mentorship but also the high regard his peers and the academic community have for his expertise. While he may not be adorned with numerous public awards, the esteem in which he is held by colleagues and students alike underscores the quiet yet profound impact of his scholarly work.

🌍 Impact and Influence

The influence of Dr. Lin’s research extends beyond the laboratory, as his findings have contributed meaningfully to clinical practices and therapeutic approaches in otolaryngology. By identifying key molecular targets and pathways involved in auditory disorders, his work continues to shape the development of novel diagnostics and treatments. Furthermore, his role in international research collaborations underscores his commitment to knowledge exchange and global scientific advancement.

🧠 Legacy and Future Contributions

Dr. Lin’s legacy is firmly rooted in the integration of molecular science with clinical otolaryngology, a field he has helped shape through decades of dedicated research and academic mentorship. As a mentor to future scientists and a contributor to critical advancements in auditory health, he remains a cornerstone in the bridge between basic science and patient care. Looking forward, his ongoing work in auditory molecular biology is poised to further uncover the mechanisms of hearing and hearing loss, promising new frontiers in medical intervention and auditory health.

🧬 Lifelong Commitment to Hearing Science

Dr. Lin’s career embodies a lifelong commitment to auditory science, from the clinic to the lab. His seamless blend of clinical knowledge, molecular expertise, and research leadership has fostered a rich legacy in otolaryngology. With ongoing contributions to scientific understanding and future discoveries on the horizon, Dr. Lin continues to inspire a generation of researchers and clinicians dedicated to improving hearing health worldwide.

Publication

  1. Title: Cell-free transcription amplification-based split-type electrochemical sensor using enzyme-linked magnetic microbeads for minimal residual leukemia detection
    Authors: Luying Yu, Jinyuan Chen, Huanjiao Weng, … Xinhua Lin, Guangxian Zhong
    Year: 2025

 

  1. Title: Antibody screening-assisted multichannel nanoplasmonic sensing chip based on SERS for viral screening and variants identification
    Authors: Yi Liu, Huanjiao Weng, Zhiwei Chen, … Shangyuan Feng, Duo Lin
    Year: 2025

 

  1. Title: tRNA methyltransferase DNMT2 promotes hepatocellular carcinoma progression and enhances Bortezomib resistance through inhibiting TNFSF10
    Authors: Junzhong Lai, Linqin Chen, Qiumei Li, … Jizhen Lin, Qi Chen
    Year: 2025

 

  1. Title: Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice
    Authors: Junzhong Lai, Jiadi Liang, Kunsen Chen, … Qi Chen, Jizhen Lin
    Year: 2024

 

  1. Title: B7H3 targeting gold nanocage pH-sensitive conjugates for precise and synergistic chemo-photothermal therapy against NSCLC
    Authors: Bing Chen, Kaifan Zheng, Shubin Fang, … Jizhen Lin, Xinhua Lin
    Year: 2023

 

  1. Title: A drug-delivery depot for epigenetic modulation and enhanced cancer immunotherapy
    Authors: Junzhong Lai, Jiadi Liang, Yong Zhang, … Jizhen Lin, Qi Chen
    Year: 2023

 

  1. Title: Ultrasensitive detection of SARS-CoV-2 antigen using surface-enhanced Raman spectroscopy-based lateral flow immunosensor
    Authors: Shuxia Lai, Yi Liu, Shubin Fang, … Jizhen Lin, Shangyuan Feng
    Year: 2023

 

  1. Title: Retraction Note to: Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner
    Authors: Xiaomin Fu, Xiaoyan Zhu, Fujun Qin, … Qinxian Zhang, Quanli Gao
    Year: Not specified

 

  1. Title: SFPQ Promotes Lung Cancer Malignancy via Regulation of CD44 v6 Expression
    Authors: Libang Yang, Jiangbo Yang, Blake A. Jacobson, … Craig A. Henke, Jizhen Lin
    Year: 2022

 

✅ Conclusion

Dr. Lin’s lifelong commitment to understanding the science of hearing has positioned him as a pioneering figure in otolaryngology. Through decades of research, academic guidance, and clinical collaboration, he has built a legacy rooted in translational science and patient-centered innovation. His work continues to influence both basic research and clinical practice, promising a future where auditory health is better understood and more effectively managed. As a scientist, mentor, and innovator, Dr. Lin stands as an enduring contributor to the advancement of hearing science.

Basanta Kumar das | Immunology | Best Researcher Award

Posted on by sciencefather

Dr. Basanta Kumar das | Immunology | Best Researcher Award

Dr. Basanta Kumar das, Central Inland Fisheries Research Institute,  India.

Dr. Basanta Kumar Das is a distinguished fisheries scientist and Director of ICAR-Central Inland Fisheries Research Institute (CIFRI), Kolkata. Born in Odisha in 1966, he pursued his Ph.D. from Orissa University of Agriculture and Technology and later completed his postdoctoral research at FRS Marine Lab, Scotland. Throughout his career, he has significantly contributed to disease management in open-water fish ecosystems, aquaculture health management, molecular epidemiology of fish diseases, and antiviral gene expression studies in carps. He has also developed medicines for ornamental fish diseases, immunostimulants, and bioactive compounds from algae and plant derivatives.

Profile

Google Scholar

 

Early Academic Pursuits 🎓

Born on March 20, 1966, in Athilabaj, District Balasore, Odisha, Dr. Basanta Kumar Das embarked on an academic journey that laid the foundation for his remarkable contributions to fisheries science. He pursued his education at the Orissa University of Agriculture and Technology, earning his Ph.D. in 1998. His relentless thirst for knowledge led him to a prestigious post-doctoral fellowship at the FRS Marine Lab in Aberdeen, Scotland, UK (2006–2007), where he deepened his expertise in aquatic health and disease management. His early academic pursuits cemented his position as a leading authority in fisheries research, blending traditional knowledge with modern scientific approaches.

Professional Endeavors and Leadership 🌊

Dr. Das has dedicated his career to revolutionizing inland fisheries and aquaculture. Currently serving as the Director of ICAR-Central Inland Fisheries Research Institute (CIFRI), Kolkata, he has spearheaded numerous initiatives to enhance aquatic resource management. Beyond his directorial role, he serves as the President of the Inland Fisheries Society of India, President of the Professional Fisheries Graduates Forum, and President of the Orissa Fisheries College Alumni Association. These leadership positions reflect his unwavering commitment to fostering scientific communities and strengthening professional networks in fisheries and aquatic sciences.

Contributions and Research Focus 🔬

Dr. Das’s research has been instrumental in addressing critical challenges in fisheries science. His expertise spans diverse areas, including disease management in open-water fish ecosystems, health management in aquaculture, and molecular epidemiological studies of fish diseases. His groundbreaking work in anti-viral gene expression studies of carps has opened new frontiers in aquatic disease control. Additionally, he has contributed significantly to the development of medicines for ornamental fish diseases, innovative immunostimulants, and bioactive compounds derived from algae and plant derivatives. His pioneering research on enclosure culture in inland open waters has transformed sustainable fisheries management, providing innovative solutions for fish conservation and productivity.

Accolades and Recognition 🏆

Dr. Das’s illustrious career has been adorned with numerous prestigious awards. He received the Jawaharlal Nehru Award for outstanding postgraduate research from ICAR, followed by the Lal Bahadur Shastri Young Scientist Award (1999–2000). His excellence in fisheries science earned him the Dr. M.S. Swaminathan Award (2011) and the Krushi Ratna Award (2016). His remarkable contributions were further acknowledged with the Eminent Zoologist of the Year Award (2017), the Ganesh Chandra Vidyarthi Award (2018), and the Best Annual Report Award (2019). In recognition of his institutional leadership, ICAR-CIFRI received the Sardar Patel Outstanding ICAR Institution Award (2020) under his direction. The pinnacle of his accolades includes the Rafi Ahmed Kidwai Award (2020) for outstanding research in agricultural sciences and the Agri-Food Empowering India Award (2021).

Impact and Influence on the Global Scientific Community 🌍

Dr. Das has built strong international collaborations, expanding the reach of Indian fisheries research to the global stage. He has established vital partnerships with WorldFish, FAO, NACA, GIZ, SAARC, BOBP, IUCN, World Bank, and leading universities such as RMIT University, University of Manitoba, University of Waterloo, and University of Aberdeen. His role in policy advisory and scientific development has helped shape sustainable aquaculture practices worldwide. Additionally, his commitment to academic mentorship is reflected in his guidance of 25 Ph.D. scholars, 35 Master’s students, two postdoctoral researchers, and two international scholars. His contribution to fisheries education and scientific discourse is further amplified by 13 MoUs with government departments, commercial enterprises, and research collaborations.

Scientific Contributions and Publications 📚

Dr. Das’s prolific research output stands as a testament to his enduring impact on fisheries science. With over 375 international publications and 8,286 citations, his work has significantly influenced the global scientific community. His extensive research on fish diseases, bioactive compounds, and molecular diagnostics has provided critical insights into improving fish health management and enhancing aquaculture sustainability. His contributions continue to be referenced by researchers, policymakers, and industry leaders worldwide, reinforcing his position as a thought leader in aquatic sciences.

Legacy and Future Contributions 🚀

As a visionary in fisheries science, Dr. Basanta Kumar Das’s contributions extend beyond research and academia. His work has set new benchmarks in disease management, aquaculture sustainability, and molecular epidemiology. His leadership in inland fisheries research will continue to drive innovations in biotechnological advancements for disease prevention, eco-friendly aquaculture techniques, and sustainable fisheries management. With a steadfast commitment to environmental conservation and scientific excellence, his legacy will inspire future generations of researchers to explore the uncharted depths of aquatic sciences and contribute to a more resilient and productive fisheries sector.

Publication

 

  • Effect of Achyranthes aspera on the immunity and survival of Labeo rohita infected with Aeromonas hydrophila
    Authors: YV Rao, BK Das, P Jyotyrmayee, R Chakrabarti
    Year: 2006

 

  • Toxicity of cypermethrin in Labeo rohita fingerlings: biochemical, enzymatic and haematological consequences
    Authors: BK Das, SC Mukherjee
    Year: 2003

 

  • Effect of Allium sativum on the immunity and survival of Labeo rohita infected with Aeromonas hydrophila
    Authors: S Sahu, BK Das, BK Mishra, J Pradhan, N Sarangi
    Year: 2007

 

  • Effect of long term administration of dietary β-glucan on immunity, growth and survival of Labeo rohita fingerlings
    Authors: CK Misra, BK Das, SC Mukherjee, P Pattnaik
    Year: 2006

 

  • Effect of Magnifera indica kernel as a feed additive on immunity and resistance to Aeromonas hydrophila in Labeo rohita fingerlings
    Authors: S Sahu, BK Das, J Pradhan, BC Mohapatra, BK Mishra, N Sarangi
    Year: 2007

 

  • Effect of multiple injections of β-glucan on non-specific immune response and disease resistance in Labeo rohita fingerlings
    Authors: CK Misra, BK Das, SC Mukherjee, P Pattnaik
    Year: 2006

 

  • Spatial distribution of meso and microplastics in the sediments of river Ganga at eastern India
    Authors: DJ Sarkar, SD Sarkar, BK Das, RK Manna, BK Behera, S Samanta
    Year: 2019

 

  • Emergence of tilapia lake virus associated with mortalities of farmed Nile tilapia Oreochromis niloticus (Linnaeus 1758) in India
    Authors: BK Behera, PK Pradhan, TR Swaminathan, N Sood, P Paria, A Das, …
    Year: 2018

 

  • A histopathological study of carp (Labeo rohita) exposed to hexachlorocyclohexane
    Authors: BK Das, SC Mukherjee
    Year: 2000

 

  • A predator–prey interaction model with self and cross-diffusion
    Authors: B Dubey, B Das, J Hussain
    Year: 2001

 

Conclusion

Dr. Basanta Kumar Das’s legacy in fisheries science is marked by groundbreaking research, transformative leadership, and unwavering dedication to advancing aquatic health, sustainable fisheries, and innovative disease management solutions. His scientific endeavors have revolutionized inland aquaculture, bridging the gap between traditional fisheries practices and modern molecular research. Through his mentorship, institutional leadership, and global collaborations, he continues to shape the next generation of fisheries scientists while working toward sustainable and eco-friendly aquaculture solutions. His lifelong commitment to fisheries research ensures that his contributions will have a lasting impact on the global fisheries sector, environmental conservation, and food security.

Bastian Höchst | Onco- Immunology | Best Researcher Award

Posted on by sciencefather

Dr. Bastian Höchst | Onco- Immunology | Best Researcher Award

Dr. Bastian Höchst,  Institute of Molecular Immunology, MRI, TUM, Germany.

Bastian Höchst is a distinguished molecular immunologist whose career spans groundbreaking research, impactful teaching, and valuable contributions to the scientific community. His academic journey began with a focus on biology and culminated in a doctorate on immune regulation in liver tumors. As a Research Group Leader at the Technical University of Munich, he investigates the complex interplay of immune cells and tissues in acute and chronic inflammation. His pioneering discoveries, such as the mechanisms governing myeloid suppressor cells and immune-regulatory metabolite transfer, have advanced understanding in the field.

Profile

Google Scholar

🌱 Early Academic Pursuits

Bastian Höchst began his academic journey with a passion for understanding the intricate mechanisms of biology. From 1999 to 2005, he pursued his studies in Biology at the University of Bonn and Hamburg, laying the foundation for his future endeavors in molecular immunology. His academic curiosity led him to pursue a doctorate at the Medical School Hannover under the guidance of Prof. Dr. Tim F. Greten. His doctoral research focused on identifying and characterizing myeloid-derived suppressor cells in patients with hepatocellular carcinoma, marking the beginning of his impactful contributions to the field of immunology.

🔬 Professional Endeavors

Currently serving as a Research Group Leader at the Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University of Munich (TUM), Bastian Höchst has dedicated his career to unraveling the complexities of immune regulation. His journey in academia has been marked by significant roles, including his previous tenure as a Research Group Leader at the Institute for Animal Physiology and Immunology, Wissenschaftszentrum Weihenstephan, TUM. Additionally, his postdoctoral fellowship at the Institute of Molecular Medicine and Experimental Immunology at the University of Bonn further honed his expertise in immune mechanisms.

🧪 Contributions and Research Focus

Bastian Höchst’s research delves into immune regulation within acute and chronic inflammatory processes, with a particular focus on tissue-specific mechanisms. He has made groundbreaking discoveries, including elucidating the pathways that govern the generation of myeloid suppressor cells in liver tumors. Furthermore, his innovative work revealed that the intercellular transfer of immune-regulatory metabolites is critical to T-cell effector functions. His research has significantly advanced the understanding of immune responses in disease contexts, bridging gaps in immunological knowledge.

🎓 Teaching and Mentorship

A dedicated educator, Bastian Höchst has been actively involved in teaching since 2010, inspiring students in life sciences programs at TUM. His lectures on topics such as onco-immunology, immune metabolism, and immunotherapy provide invaluable insights to aspiring scientists. Through lab courses on immune cell phenotyping and advanced techniques like spectral flow cytometry, he has empowered students with the skills to explore the complexities of immunology. His teaching contributions extend beyond knowledge dissemination, fostering a generation of critical thinkers and innovators.

📜 Accolades and Recognition

Bastian’s expertise has been recognized through his habilitation and venia legendi for Molecular Immunology, under the mentorship of Prof. Dr. Percy Knolle. His contributions as a scientific reviewer for prestigious journals like Hepatology, Journal of Hepatology, and Frontiers in Immunology further reflect his authority in the field. Additionally, his role in evaluating grant applications for the Deutsche Forschungsgemeinschaft (DFG) underscores his impact on shaping future research initiatives.

🌍 Impact and Influence

Through his research, teaching, and reviews, Bastian Höchst has left an indelible mark on the field of molecular immunology. His work not only uncovers critical mechanisms of immune regulation but also provides pathways for therapeutic advancements in inflammatory and tumor-related conditions. His contributions influence both scientific understanding and practical applications, addressing global challenges in health and disease management.

🌟 Legacy and Future Contributions

Bastian Höchst’s journey is one of passion, discovery, and impact. As he continues to lead groundbreaking research, he sets the stage for a future where immune-based therapies are revolutionized. His legacy lies in his ability to connect fundamental research with real-world applications, inspiring colleagues and mentees alike. With his unwavering commitment to scientific exploration, Bastian Höchst is poised to shape the future of molecular immunology, paving the way for transformative breakthroughs.

Publication

  • A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4+ CD25+ Foxp3+ T cells
    Authors: B. Höchst, L.A. Ormandy, M. Ballmaier, F. Lehner, C. Krüger, M.P. Manns, …
    Year: 2008

 

  • Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor
    Authors: B. Höchst, T. Voigtlaender, L. Ormandy, J. Gamrekelashvili, F. Zhao, …
    Year: 2009

 

  • Functional classification of memory CD8+ T cells by CX3CR1 expression
    Authors: J.P. Böttcher, M. Beyer, F. Meissner, Z. Abdullah, J. Sander, B. Höchst, …
    Year: 2015

 

  • Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells
    Authors: B. Höchst, J. Gamrekelashvili, M.P. Manns, T.F. Greten, F. Korangy
    Year: 2011

 

  • S100A9 a new marker for monocytic human myeloid‐derived suppressor cells
    Authors: F. Zhao, B. Höchst, A. Duffy, J. Gamrekelashvili, S. Fioravanti, M.P. Manns, …
    Year: 2012

 

  • Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal
    Authors: T. Baumann, A. Dunkel, C. Schmid, S. Schmitt, M. Hiltensperger, K. Lohr, …
    Year: 2020

 

  • Kupffer cell-derived Tnf triggers cholangiocellular tumorigenesis through JNK due to chronic mitochondrial dysfunction and ROS
    Authors: D. Yuan, S. Huang, E. Berger, L. Liu, N. Gross, F. Heinzmann, M. Ringelhan, …
    Year: 2017

 

  • Low-dose cyclophosphamide treatment impairs regulatory T cells and unmasks AFP-specific CD4+ T-cell responses in patients with advanced HCC
    Authors: T.F. Greten, L.A. Ormandy, A. Fikuart, B. Höchst, S. Henschen, M. Hörning, …
    Year: 2010

 

Conclusion

Bastian Höchst’s career exemplifies dedication to advancing molecular immunology through innovative research, education, and mentorship. His contributions have shaped the understanding of immune responses in disease contexts, offering hope for novel therapeutic approaches. As he continues to lead impactful research and foster new talent, Bastian Höchst remains a visionary in his field, poised to drive future breakthroughs that bridge science and medicine for the benefit of society.