Prof. Dr. Yuxin Yin | The Chinese University of Hong Kong | China
Yuxin Yin is a Presidential Chair Professor at the School of Medicine, The Chinese University of Hong Kong, Shenzhen, recognized for pioneering contributions to molecular oncology, genome stability, and translational systems biomedicine. Trained at UNC-Chapel Hill and Princeton and previously a tenured professor at Columbia University, he later led basic medical sciences at Peking University before joining CUHK-Shenzhen. His research dissects tumor-suppressor signaling networks, including p53 and PTEN pathways, DNA-replication stress responses, genome-stability mechanisms, and the immunological dynamics that shape cancer progression. He has also advanced AI-driven metabolomics for early cancer screening, contributing to cross-disciplinary integration between cancer biology, data science, and neuroscience-inspired approaches. With more than 189 publications and an extensive research portfolio of approximately 190 completed and ongoing projects, his work has been cited over 7,264 times, with 6,352 citing articles and an average of 38.43 citations per item. He holds an H-index of 45, reflecting sustained global influence in cancer biology and biomedical innovation. Beyond academia, Yin contributes to translational and industry-facing initiatives, including AI-metabolomics screening programs and multidisciplinary collaborations that accelerate precision medicine. His leadership and scientific achievements continue to shape emerging directions in cancer research, systems biomedicine, and next-generation diagnostic technologies.
Featured Publications
Lu, Y., Ding, D., Chen, H., Jiang, P., Luo, J., Shan, H., Wang, G., Luo, J., and Yin, Y. (2025). Structural determination of the human taurine transporter TauT reveals the mechanism of substrate and inhibitor recognition. Cell Reports, 116591.
Shen, Z., Zhong, A., Zhang, C., Tang, X., Zhao, X., Hou, Z., Liang, H., and Yin, Y. (2025). LncPTEN1, a long non-coding RNA generated from PTEN, suppresses lung cancer metastasis through the regulation of EMT progress. Non-coding RNA Research.
Tang, X., Zhang, Q., Shen, Z., Xiao, J., Li, M., Meng, X., Wang, C., Zhang, G., Liu, A., and Yin, Y. (2025). Single-cell multi-omics analysis reveals cancer regulatory elements of transcriptional programs and clinical implications. Cell Death & Disease.
Liu, A., Xiao, J., Wang, C., Meng, X., He, C., Li, M., Zhang, G., Tang, X., and Yin, Y. (2025). Single-cell multi-omics analysis reveals the plasticity of isthmus stem cells in gastric carcinogenesis. Computers in Biology and Medicine, 110662.
Li, Y., Zhou, J., Zhang, Z., Jiang, S., Yin, Q., Xiao, J., Li, X., Yin, Y., Ye, L., Peng, S., et al. (2025). RPA1 protects DNA damage induced PANoptosis in limb development. Science Advances.
Yu, S., Ding, J., Wang, J., Wang, W., Zuo, P., Yang, A., Dai, Z., Yin, Y., Sun, J., and Liang, L. (2025). Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway. Nature Communications.