Jeffrey Holt | Hearing and Sensory Transduction | Lifetime achievement Award

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Prof. Jeffrey Holt | Hearing and Sensory Transduction | Lifetime achievement Award

Prof. Jeffrey Holt,Ā  Harvard Medical School / Boston Children’s Hospital, United States.

Dr. Jeffrey R. Holt is a distinguished scientist whose groundbreaking contributions to auditory neuroscience and inner ear physiology have significantly advanced the field of otolaryngology. Currently serving as a Professor of Otolaryngology and Neurology at Boston Childrenā€™s Hospital and Harvard Medical School, Dr. Holt’s career is marked by an unwavering commitment to understanding the molecular and physiological mechanisms underlying hearing and balance disorders.

Profile

Google Scholar

 

Early Academic Pursuits šŸŽ“

Born in Buffalo, NY, Dr. Holt’s passion for science was evident early in his academic journey. He earned his Bachelor of Science degree in Biology from Wofford College in 1986, laying a strong foundation in the life sciences. His quest for knowledge led him to the University of Rochester, where he pursued a Masterā€™s degree in Physiology in 1992, followed by a Ph.D. in Physiology in 1995. His doctoral research provided deep insights into the intricate workings of sensory physiology, setting the stage for his future research endeavors in auditory neuroscience.

Professional Endeavors and Leadership šŸ‘©ā€šŸ’¼

Following his Ph.D., Dr. Holt embarked on postdoctoral training at Harvard Medical School, Massachusetts General Hospital, and the Howard Hughes Medical Institute. His extensive training in neurobiology enabled him to transition into academic roles, beginning as an Instructor in Neurobiology at Harvard Medical School and Massachusetts General Hospital from 1999 to 2001. He later joined the University of Virginia as an Assistant Professor of Neuroscience, where he progressed to Associate Professor before returning to Harvard in 2011. Since 2016, he has held the esteemed position of Professor of Otolaryngology at Boston Childrenā€™s Hospital and Harvard Medical School, as well as a faculty affiliation with the Harvard-MIT Health Sciences and Technology (HST) program.

Contributions and Research Focus šŸŒ

Dr. Holt’s pioneering research has been instrumental in decoding the molecular basis of hearing and balance disorders. His work focuses on sensory hair cells of the inner ear, aiming to uncover the genetic and physiological mechanisms that contribute to hearing loss. His studies have explored ion channel function, hair cell mechanotransduction, and gene therapy approaches for hereditary deafness. His innovative research has opened new avenues for therapeutic interventions, including the development of gene therapies targeting Usher syndrome and other genetic hearing disorders.

Accolades and Recognition šŸ†

Throughout his career, Dr. Holt has been widely recognized for his contributions to auditory science. He has played key leadership roles in prestigious scientific organizations, serving as Chair of the Usher Syndrome Society Scientific Advisory Committee and Co-Chair of major international conferences such as the Keystone Conference on Sensory Systems and the New York Academy of Sciences Meeting. His service on various NIH and NIDCD advisory committees reflects his influence in shaping national research priorities in hearing and balance disorders.

Impact and Influence on Scientific Community šŸŒ

Dr. Holtā€™s impact extends beyond research, as he has been a dedicated mentor and educator throughout his career. He has guided numerous graduate students and postdoctoral fellows, serving on thesis and qualifying exam committees at Harvard Medical School. As a course director and research mentor, he has played a crucial role in training the next generation of auditory neuroscientists. His leadership in academic and scientific communities has helped bridge the gap between fundamental research and clinical applications in hearing restoration.

Legacy and Future Contributions šŸ’Ŗ

With a legacy rooted in groundbreaking discoveries and scientific leadership, Dr. Holt continues to push the boundaries of auditory neuroscience. His ongoing research in gene therapy for hereditary deafness holds the promise of transforming lives through novel treatments for hearing loss. As a visionary in the field, his work is set to inspire future advancements in otolaryngology, offering hope to millions affected by hearing and balance disorders worldwide. His dedication to research, education, and clinical impact ensures that his contributions will leave a lasting imprint on auditory science for generations to come.

 

Publication

  • TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
    Authors: DP Corey, J GarcĆ­a-AƱoveros, JR Holt, KY Kwan, SY Lin, MA Vollrath, …
    Year: 2004

 

  • Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
    Authors: X Gao, Y Tao, V Lamas, M Huang, WH Yeh, B Pan, YJ Hu, JH Hu, …
    Year: 2018

 

  • Mechanotransduction in mouse inner ear hair cells requires transmembrane channelā€“like genes
    Authors: Y Kawashima, GSG GĆ©lĆ©oc, K Kurima, V Labay, A Lelli, Y Asai, …
    Year: 2011

 

  • TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear
    Authors: B Pan, GS GĆ©lĆ©oc, Y Asai, GC Horwitz, K Kurima, K Ishikawa, …
    Year: 2013

 

  • Continuous evolution of base editors with expanded target compatibility and improved activity
    Authors: BW Thuronyi, LW Koblan, JM Levy, WH Yeh, C Zheng, GA Newby, …
    Year: 2019

 

  • Differential distribution of stem cells in the auditory and vestibular organs of the inner ear
    Authors: K Oshima, CM Grimm, CE Corrales, P Senn, R Martinez Monedero, …
    Year: 2007

 

  • A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells
    Authors: JR Holt, SKH Gillespie, DW Provance, K Shah, KM Shokat, DP Corey, …
    Year: 2002

 

  • A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
    Authors: LD Landegger, B Pan, C Askew, SJ Wassmer, SD Gluck, A Galvin, …
    Year: 2017

 

  • Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links
    Authors: W Denk, JR Holt, GMG Shepherd, DP Corey
    Year: 1995

 

  • TMC1 forms the pore of mechanosensory transduction channels in vertebrate inner ear hair cells
    Authors: B Pan, N Akyuz, XP Liu, Y Asai, C Nist-Lund, K Kurima, BH Derfler, …
    Year: 2018

 

Conclusion šŸŽÆ

Dr. Holtā€™s contributions to auditory neuroscience have revolutionized the field, bridging fundamental research with clinical applications. His groundbreaking work in gene therapy holds immense potential for treating hereditary hearing disorders, making a profound impact on global healthcare. As a researcher, educator, and leader, his legacy will continue to inspire innovation in otolaryngology and improve the lives of individuals affected by hearing and balance impairments for generations to come.

 

Xiaobing Yan | Neurotechnology | Best Researcher Award

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Prof. Xiaobing Yan | Neurotechnology | Best Researcher Award

Prof. Xiaobing Yan, Hebei University, China.

Professor Xiaobing Yan is a distinguished researcher specializing in novel memory devices and memristor-based brain-inspired chip technologies. As a Senior Member of IEEE and a reviewer for leading journals, he has made significant contributions to the field of neuromorphic engineering. His outstanding achievements include recognition as a Young Changjiang Scholar and a Young Top-notch Talent under China’s National Ten Thousand Talents Program. With over 120 high-impact publications, 5,600+ citations, and an H-index of 40, he is globally recognized among the top 2% of scientists. His research has been supported by several prestigious national and provincial funding programs.

Profile

Scopus

šŸŽ“ Early Academic Pursuits

Xiaobing Yan embarked on his academic journey with a deep passion for electronics and information engineering. His early years were marked by an unwavering dedication to understanding the complexities of memory devices and neuromorphic systems. As he progressed through his studies, his curiosity and drive led him to explore the intersection of artificial intelligence and hardware development. His rigorous academic training laid a solid foundation for his future contributions to next-generation computing technologies.

šŸ’Ŗ Professional Endeavors

Currently serving as a Professor at the Institute of Life Science and Green Development, Hebei University, Xiaobing Yan has established himself as a distinguished leader in the field of electronic engineering. He is a Doctoral Supervisor and a Senior Member of IEEE, a testament to his vast expertise and influence in the scientific community. His role extends beyond academia, as he actively engages in national-level research programs and collaborates with top-tier research institutions. His professional journey is a testament to his commitment to pioneering advancements in neuromorphic computing and memristor-based brain-inspired chip technologies.

šŸ¤– Contributions and Research Focus

Xiaobing Yanā€™s research primarily revolves around novel memory devices and brain-like computing systems. His work has been instrumental in the advancement of memristor-based chip technologies, which hold the potential to revolutionize artificial intelligence hardware. By bridging the gap between neuroscience and semiconductor innovation, he is contributing to the development of energy-efficient, high-performance computing architectures. His research projects, funded by prestigious national programs, aim to push the boundaries of nanoelectronics and intelligent systems.

šŸ† Accolades and Recognition

Xiaobing Yanā€™s groundbreaking work has earned him widespread recognition. In 2019, he was honored as a Young Changjiang Scholar by the Ministry of Education and selected as a Young Top-notch Talent under the National Ten Thousand Talents Program. In 2024, he further cemented his legacy by winning the Excellence Award at the National Disruptive Innovation Technology Competition. His contributions are not only recognized in China but also on a global scale, as he has been listed among the top 2% of scientists worldwide by Stanford University.

šŸŒŸ Impact and Influence

With over 120 high-impact publications and more than 5,600 citations, Xiaobing Yanā€™s research has significantly shaped the field of electronics and artificial intelligence. His H-index of 40 reflects the depth and relevance of his contributions. As a reviewer for prestigious journals such as Nature Electronics, Advanced Materials, and ACS Nano, he plays a crucial role in shaping the direction of cutting-edge research. His influence extends beyond his publications, as he mentors young researchers and fosters collaborations that drive innovation in neuromorphic computing.

šŸš€ Legacy and Future Contributions

As a leader in disruptive technology and nanoelectronics, Xiaobing Yan is poised to continue pushing the boundaries of scientific discovery. His ongoing research projects, including multiple National Key R&D initiatives and collaborations with leading institutions, demonstrate his commitment to pioneering breakthroughs in brain-inspired computing. With his vision and expertise, he is set to leave a lasting legacy in the development of next-generation intelligent systems, shaping the future of artificial intelligence and semiconductor technology.

Publication

  1. In situ training of an in-sensor artificial neural network based on ferroelectric photosensors

    • Authors: H. Lin, Haipeng; J. Ou, Jiali; Z. Fan, Zhen; X. Gao, Xingsen; J. Liu, Junming
    • Year: 2025

 

  1. Ultra robust negative differential resistance memristor for hardware neuron circuit implementation

    • Authors: Y. Pei, Yifei; B. Yang, Biao; X. Zhang, Xumeng; S. Li, Shushen; X. Yan, Xiaobing
    • Year: 2025

 

  1. Physical unclonable in-memory computing for simultaneous protecting private data and deep learning models

    • Authors: W. Yue, Wenshuo; K. Wu, Kai; Z. Li, Zhiyuan; R. Huang, Ru; Y. Yang, Yuchao
    • Year: 2025

 

  1. Memristor-based feature learning for pattern classification

    • Authors: T. Shi, Tuo; L. Gao, Lili; Y. Tian, Yang; X. Yan, Xiaobing; Q. Liu, Qi
    • Year: 2025

 

  1. Harnessing spatiotemporal transformation in magnetic domains for nonvolatile physical reservoir computing

    • Authors: J. Zhou, Jing; J. Xu, Jikang; L. Huang, Lisen; X. Yan, Xiaobing; S.T. Lim, Sze Ter
    • Year: 2025

 

  1. Flexoelectric Effect in Thin Films: Theory and Applications

    • Authors: X. Jia, Xiaotong; R. Guo, Rui; J. Chen, Jingsheng; X. Yan, Xiaobing
    • Year: 2025

 

  1. Deoxyribonucleic acid brick crystals-based memristor as an artificial synapse for neuromorphic computing

    • Authors: Z. Wang, Zhongrong; X. Liu, Xinran; J. Li, Jiahang; J. Lou, Jianzhong; X. Yan, Xiaobing
    • Year: 2025

 

  1. Weighted Echo State Graph Neural Networks Based on Robust and Epitaxial Film Memristors

    • Authors: Z. Guo, Zhenqiang; G. Duan, Guojun; Y. Zhang, Yinxing; Y. Faraj, Yousef; X. Yan, Xiaobing
    • Year: 2025

 

  1. Achieving over 10 % efficiency in kesterite solar cells via selenium-free annealing

    • Authors: Q. Zhou, Qing; Y. Cong, Yijia; H. Li, Hao; Y. Sun, Yali; W. Yu, Wei
    • Year: 2024

 

  1. Hardware implementation of memristor-based artificial neural networks

  • Authors: F.L. Aguirre, Fernando L.; A. Sebastian, Abu; M. Le Gallo, Manuel; S. Matias Pazos, Sebastian; M. Lanza, Mario
  • Year: 2024

 

Conclusion

Professor Yanā€™s work plays a pivotal role in advancing memory technology and brain-inspired computing. His extensive research contributions and leadership in high-impact projects underscore his expertise in developing next-generation computing technologies. His global recognition and numerous accolades highlight his influence in the field, positioning him as a key figure in neuromorphic engineering and memory device innovation.