William Mills III | Translational Neuroscience | Best Researcher Award

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Dr. William Mills III | Translational Neuroscience | Best Researcher Award

Dr. William Mills III, University of Virginia, United States.

William A. Mills III, known as Tré, is a dedicated neuroscientist whose academic and professional journey reflects a strong commitment to translational and interdisciplinary research. With foundational training from Virginia Tech and international exposure through studies in China, Tré has developed a deep expertise in neurovascular coupling and glial biology. His doctoral and postdoctoral research has significantly advanced our understanding of how microglia and aging influence the brain’s vascular systems. Through prestigious fellowships and awards, including the NIH K99/R00 and the AHA Postdoctoral Fellowship, Tré has proven his potential to become a leading figure in neuroscience. His work bridges multiple scientific disciplines and focuses on uncovering mechanisms that contribute to neurological aging and disease.

Profile

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🎓 Early Academic Pursuits

William A. Mills III, fondly known as Tré, laid a solid foundation for his scientific career through rigorous and diverse academic training. He earned his Bachelor of Science degree in Biological Sciences from Virginia Tech in 2014, where he was actively involved in research labs focusing on virology, behavioral ecology, and disease ecology. His passion for cross-cultural and interdisciplinary learning was evident as he pursued Chinese language studies at Xi’an Jiaotong-Liverpool University from 2014 to 2015. This global academic exposure was followed by his Ph.D. in Translational Biology, Medicine & Health with a neuroscience focus at Virginia Tech (2015–2021), where he developed a strong interest in neurovascular and glial biology. These formative experiences created a well-rounded and curious scientist ready to tackle complex biomedical questions.

🧠 Professional Endeavors in Neuroscience

Tré’s professional journey took a pivotal turn when he joined the Eyo Lab at the University of Virginia as a Postdoctoral Research Fellow in 2021. His research investigates the intricate role of microglia in regulating capillary basal tone and neurovascular coupling—an area that sits at the intersection of neuroimmunology and vascular biology. His graduate years in the Sontheimer Lab had already shaped his expertise in glial signaling pathways, particularly focusing on the effects of aging on gliovascular interactions involving EGFR and pSTAT3. These experiences underscore a continuous commitment to understanding the cellular mechanisms that underpin brain function and disease.

🧪 Contributions and Research Focus

Throughout his research career, Tré has contributed significantly to the field of neurovascular biology and glial cell research. His scientific curiosity has spanned from studying the cellular mechanics of viral encapsidation in early projects to evaluating semaphorin roles in cardiovascular pathology. Notably, his doctoral work on gliovascular plasticity and his current postdoctoral focus on microglia’s role in cerebral blood flow regulation highlight his interdisciplinary approach. By bridging neuroscience, immunology, and vascular biology, he is shedding light on the fundamental processes that maintain brain health and how their disruption leads to age-related and neurodegenerative diseases.

🏅 Accolades and Recognition

Tré’s outstanding research potential has been recognized by several prestigious institutions. He was awarded the American Heart Association Career Development Award (which he respectfully declined), the American Heart Association Postdoctoral Fellowship (25POST1376070), and the UVA Brain Institute Postdoctoral Research Fellowship. In addition, he secured training support through the UVA Cardiovascular Research Center T32 Training Grant, reflecting the strong institutional belief in his capabilities. Most notably, he earned the competitive NIH K99/R00 Pathway to Independence Award, a mark of distinction for early-career researchers poised to transition to faculty positions.

🔬 Impact and Influence in Translational Neuroscience

Tré’s research contributions are highly translational in nature, linking basic cellular mechanisms to potential therapeutic implications in aging, stroke, and neurodegeneration. His work on microglial function in neurovascular coupling could provide new insights into how blood flow dysregulation contributes to cognitive decline and dementia. By exploring how aging alters glial and vascular interactions, Tré’s research holds the promise to inform interventions targeting the brain’s support systems to preserve function in aging populations. His influence is also visible through collaborative projects, lab mentorship, and participation in international research endeavors.

🌍 Legacy and Future Contributions

Looking ahead, Tré is poised to leave a lasting legacy in the field of neurovascular biology. With a trajectory marked by intellectual rigor, global awareness, and translational relevance, he is expected to lead pioneering studies that will redefine our understanding of brain support systems in health and disease. The foundation laid by his NIH K99/R00 award positions him well to establish an independent research program, where he will likely mentor future scientists and push the boundaries of neuroscience through integrative and innovative research methodologies.

🧬 A Champion of Interdisciplinary Science

A defining trait of Tré’s career is his seamless integration of diverse scientific fields—ranging from immunology and neuroscience to cardiovascular biology and behavioral ecology. This interdisciplinary ethos not only enriches his research output but also positions him as a bridge-builder in science, capable of uniting different perspectives to address complex biomedical challenges. His academic journey from microbiology and animal behavior to glial biology exemplifies a dynamic scientist committed to evolving with the science, while remaining grounded in his passion for discovery.

Publication

  • Title: Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
    Authors: K. Bisht, K.A. Okojie, K. Sharma, D.H. Lentferink, Y.Y. Sun, H.R. Chen, …
    Year: 2021

 

  • Title: Spatially expandable fiber-based probes as a multifunctional deep brain interface
    Authors: S. Jiang, D.C. Patel, J. Kim, S. Yang, W.A. Mills III, Y. Zhang, K. Wang, Z. Feng, …
    Year: 2020

 

  • Title: Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age
    Authors: W.A. Mills III, A.L.M. Woo, S. Jiang, J. Martin, D. Surendran, M. Bergstresser, …
    Year: 2022

 

  • Title: Lactobacillus rescues postnatal neurobehavioral and microglial dysfunction in a model of maternal microbiome dysbiosis
    Authors: Y. Lebovitz, E.A. Kowalski, X. Wang, C. Kelly, M. Lee, V. McDonald, R. Ward, …
    Year: 2019

 

  • Title: Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes
    Authors: S.C. Campbell, C. Muñoz-Ballester, L. Chaunsali, W.A. Mills III, J.H. Yang, …
    Year: 2020

 

  • Title: LRRTM1 underlies synaptic convergence in visual thalamus
    Authors: A. Monavarfeshani, G. Stanton, J. Van Name, K. Su, W.A. Mills III, K. Swilling, …
    Year: 2018

 

  • Title: EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke
    Authors: B. Okyere, W.A. Mills, X. Wang, M. Chen, J. Chen, A. Hazy, Y. Qian, J.B. Matson, …
    Year: 2020

 

  • Title: Nano-optoelectrodes integrated with flexible multifunctional fiber probes by high-throughput scalable fabrication
    Authors: S. Jiang, J. Song, Y. Zhang, M. Nie, J. Kim, A.L. Marcano, K. Kadlec, …
    Year: 2021

 

  • Title: The emergence of the calvarial hematopoietic niche in health and disease
    Authors: W.A. Mills III, M.A. Coburn, U.B. Eyo
    Year: 2022

 

  • Title: Using zebrafish to elucidate glial-vascular interactions during CNS development
    Authors: R.A. Umans, C. Pollock, W.A. Mills III, K.C. Clark, Y.A. Pan, H. Sontheimer
    Year: 2021

 

🧾 Conclusion

Tré stands out as a forward-thinking and highly skilled researcher whose contributions are shaping the future of neurovascular and glial research. His innovative approach, academic excellence, and recognition by top funding agencies underscore his suitability for leadership roles in neuroscience. As he transitions into an independent research career, Tré is expected to make enduring impacts on the scientific community through groundbreaking discoveries, mentorship, and interdisciplinary collaboration. His trajectory is a testament to his dedication, curiosity, and potential to transform brain health research.

Ling-Yan Su | Molecular Neuroscience | Best Researcher Award

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Dr. Ling-Yan Su | Molecular Neuroscience | Best Researcher Award

Dr. Ling-Yan Su, Yunnan Agricultural University, China.

Professor Ling-Yan Su is a leading figure in the field of food science and plant physiology, currently serving at the College of Food Science and Technology, Yunnan Agricultural University. With a solid academic foundation from Yunnan University and the Chinese Academy of Sciences, she has built a dynamic career that bridges molecular biology and applied agricultural research. Her pioneering work on melatonin-based pre-harvest treatments has significantly advanced our understanding of natural preservation techniques, especially in prolonging the post-harvest life and quality of fruits like Myrica rubra. Her research focuses on enhancing antioxidant systems, inhibiting spoilage, and activating plant defense pathways through sustainable, low-toxicity treatments.

Profile

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🎓 Early Academic Pursuits

Ling-Yan Su’s journey in the biological sciences began with a Bachelor of Science degree from the School of Life Science at Yunnan University (2007–2011). Demonstrating academic curiosity and determination early on, she expanded her horizons through a year-long visiting student program (2010–2011) at the prestigious Kunming Institute of Zoology, affiliated with the Chinese Academy of Sciences. This experience laid the foundation for her doctoral research, which she pursued at the same institute from 2011 to 2017, where she rigorously explored complex biological systems, further solidifying her passion for food science and plant physiology.

🧪 Professional Endeavors in Science

Professor Su’s professional career has been marked by consistent growth across esteemed academic institutions. Following her Ph.D., she joined the Kunming Institute of Zoology as a research assistant, rapidly advancing to the role of associate professor. In 2022, she transitioned to the College of Food Science and Technology at Yunnan Agricultural University, initially as an associate professor before her promotion to full professor within the same year. Her academic trajectory reflects a blend of deep research engagement and an evolving role in shaping food science education and innovation in China.

🌿 Contributions and Research Focus

Professor Su’s groundbreaking work lies at the intersection of plant physiology, post-harvest fruit biology, and food preservation technology. She has made significant contributions to understanding how melatonin, a naturally occurring compound, can be leveraged to extend the post-harvest shelf life of Myrica rubra (Chinese bayberry). Her studies demonstrate that melatonin pre-harvest treatments reduce oxidative stress markers, inhibit microbial decay, and activate the phenylpropanoid pathway, resulting in elevated antioxidant activity. This line of research not only reveals novel mechanisms of fruit preservation but also opens sustainable avenues in post-harvest biology and food safety.

🏅 Accolades and Recognition

While formal awards are not listed, Professor Su’s rapid academic promotions and appointments at prestigious research institutes such as the Chinese Academy of Sciences and Yunnan Agricultural University underscore her recognition within the scientific community. Her work is contributing to a growing body of literature on sustainable food science innovations, earning her esteem among peers and collaborators in the agricultural biotechnology field.

🌱 Impact and Influence

Professor Su’s innovative application of melatonin in fruit preservation has substantial implications for food technology and agricultural practices. Her research directly addresses global concerns such as food spoilage, post-harvest losses, and chemical-free preservation methods. By enhancing natural antioxidant defenses and inhibiting spoilage at a molecular level, her work supports both farmers and consumers in accessing healthier and longer-lasting produce, especially within the context of environmentally conscious food systems.

🔬 Legacy in Food Science

The legacy Professor Su is building centers around translating scientific inquiry into practical solutions for real-world agricultural challenges. Her research is charting a course for future studies in the bio-preservation of fruits and vegetables using natural treatments. As she continues to mentor students and collaborate across disciplines, her influence is extending into the next generation of food scientists and researchers focused on plant biochemistry, post-harvest technology, and sustainable agricultural innovation.

🚀 Future Contributions and Vision

Looking ahead, Professor Ling-Yan Su is poised to further explore how endogenous compounds like melatonin can be applied across various fruits and food crops. Her vision includes broadening the scope of natural food preservation strategies and delving deeper into molecular pathways that regulate plant defense responses. As a respected academic and scientist, her future contributions are expected to shape healthier food systems and deepen scientific understanding of plant–microbe–compound interactions.

Publication

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    Authors: DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, …
    Year: 2021

 

  • Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
    Authors: R Luo, LY Su, G Li, J Yang, Q Liu, LX Yang, DF Zhang, H Zhou, M Xu, …
    Year: 2020

 

  • Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation
    Authors: LY Su, H Li, L Lv, YM Feng, GD Li, R Luo, HJ Zhou, XG Lei, L Ma, JL Li, …
    Year: 2015

 

  • Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin
    Authors: YM Feng, YF Jia, LY Su, D Wang, L Lv, L Xu, YG Yao
    Year: 2013

 

  • Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China
    Authors: D Wang, L Xu, L Lv, LY Su, Y Fan, DF Zhang, R Bi, D Yu, W Zhang, XA Li, …
    Year: 2015

 

  • Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine
    Authors: LY Su, R Luo, Q Liu, JR Su, LX Yang, YQ Ding, L Xu, YG Yao
    Year: 2017

 

  • Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication
    Authors: MS Wang, R Zhang, LY Su, Y Li, MS Peng, HQ Liu, L Zeng, DM Irwin, …
    Year: 2016

 

  • Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation
    Authors: Q Liu, LY Su, C Sun, L Jiao, Y Miao, M Xu, R Luo, X Zuo, R Zhou, P Zheng, …
    Year: 2020

 

  • Out of Southern East Asia of the brown rat revealed by large-scale genome sequencing
    Authors: L Zeng, C Ming, Y Li, LY Su, YH Su, NO Otecko, A Dalecky, S Donnellan, …
    Year: 2018

 

  • Moringa oleifera Lam. leaves as new raw food material: A review of its nutritional composition, functional properties, and comprehensive application
    Authors: M Yang, L Tao, XR Kang, ZL Wang, LY Su, LF Li, F Gu, CC Zhao, J Sheng, …
    Year: 2023

 

✅ Conclusion

Professor Su’s academic journey and research contributions exemplify scientific excellence rooted in sustainability and innovation. Her work not only provides practical solutions to post-harvest challenges but also contributes to broader efforts in reducing food waste and promoting natural preservation methods. As she continues to mentor young researchers and expand her studies, Professor Su is well-positioned to leave a lasting impact on food science and agricultural biotechnology. Her career reflects a thoughtful integration of research, application, and forward-looking vision in the quest for healthier and more resilient food systems.

Jagadeesh Rao | Neuropharmacology | Best Researcher Award

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Dr. Jagadeesh Rao | Neuropharmacology | Best Researcher Award

Dr. Jagadeesh Rao,  IGC Pharma LLC, United States.

Dr. Jagadeesh S. Rao is a distinguished neuroscientist and clinical researcher with over 15 years of experience in neuroscience, psychiatry, neuropharmacology, and drug development. His career is marked by significant contributions to the understanding and treatment of neurodegenerative diseases, especially Alzheimer’s disease. With a strong academic foundation in molecular biology and biochemistry, Dr. Rao has led groundbreaking work in clinical trial design, preclinical toxicology, and regulatory submissions, including IND and CMC documentation for FDA approvals. He currently serves as Principal Scientist at IGC Pharma Inc., where he leads teams in Phase I and II clinical trials, manages CROs and budgets, and has developed both OTC and investigational drug products.

Profile

Orcid

🧠 Early Academic Pursuits

Dr. Jagadeesh S. Rao began his scientific journey with a deep interest in the complexities of the human brain and molecular biology. From the early stages of his academic training, he demonstrated exceptional dedication to exploring the interplay between neurobiology, biochemistry, and psychiatric health. His pursuit of a Ph.D. laid a robust foundation in neuroscience and neuropharmacology, equipping him with a multidisciplinary understanding of the cellular and molecular mechanisms that underlie neurodegenerative and neuropsychiatric disorders. This strong academic grounding would later become the driving force behind his innovative contributions to research in pain, Alzheimer’s disease, and drug development.

🧪 Professional Endeavors in Neuroscience and Drug Development

With over 15 years of professional experience, Dr. Rao has successfully navigated and led multiple domains including toxicology, psychiatry, and molecular biology. Currently serving as a Principal Scientist at IGC Pharma Inc., he has taken a prominent role in advancing clinical drug development, particularly in designing and executing Phase I and II trials. His expertise extends to critical regulatory processes such as Investigational New Drug (IND) submissions, clinical protocol design, and Chemistry, Manufacturing, and Controls (CMC). He has actively led teams in drug formulation, batch production, validation, and compliance with FDA and ISO standards—demonstrating a blend of scientific acumen and regulatory insight.

🧬 Contributions and Research Focus in Neuropharmacology

Dr. Rao’s research centers on developing therapeutic interventions for neurodegenerative and neuropsychiatric conditions, especially Alzheimer’s disease. His contributions span the full spectrum of drug development: from preclinical toxicology and pharmacokinetics to clinical pharmacodynamics and regulatory documentation. He has designed preclinical studies adhering to GLP standards, involving mutagenesis assays, reproductive and general toxicity assessments, and immunogenicity tests. Moreover, he played a key role in the development of over-the-counter (OTC) pain relief cream products, contributing both to academic research and commercial innovation. His insights into P450 enzyme polymorphisms and their effects on drug metabolism showcase a precision medicine approach to pharmacological care.

🏅 Accolades and Recognition in Clinical Research

While much of Dr. Rao’s work has been behind the scenes of scientific advancement and regulatory excellence, his leadership in preparing CMC documents and overseeing investigational drug submissions has earned him widespread respect among peers. His oversight of departmental budgets and his management of Clinical Research Organizations (CROs) reflect not only scientific brilliance but also strategic and financial stewardship in clinical drug development. The successful initiation of Phase I and II clinical trials under his guidance stands as a testament to his expertise and diligence in the field.

🌍 Impact and Influence in Translational Medicine

Dr. Rao’s work bridges the gap between laboratory research and clinical application. His projects have advanced the translational medicine field by offering therapeutic candidates that move seamlessly from preclinical safety assessments to human trials. His influence is felt not only through the innovative drugs developed under his watch but also in shaping protocols that align with FDA’s stringent regulatory frameworks. His understanding of the molecular intricacies of neuropsychiatric diseases allows him to propose and test interventions that directly respond to the unmet needs of patients and healthcare systems alike.

🔬 Legacy in Scientific Rigor and Innovation

One of Dr. Rao’s enduring legacies lies in his rigorous approach to clinical pharmacology and his commitment to quality and safety in every phase of drug development. His ability to interpret complex PK/PD data, assess drug-drug interactions, and foresee adverse events has significantly shaped safer and more effective drug protocols. He has also contributed to the creation of technical documentation and risk assessments that serve as gold standards in the field, ensuring compliance and reproducibility for future scientists and clinicians.

🚀 Future Contributions and Vision for Neurotherapeutics

Looking ahead, Dr. Rao continues to pave the way in neurotherapeutics with a focused ambition to develop treatments for cognitive and behavioral disorders rooted in neuroinflammation and synaptic dysfunction. His vision includes refining clinical strategies using personalized medicine models and leveraging his expertise in biochemistry and molecular neuropharmacology. As the global demand for effective neurological therapies increases, Dr. Rao’s evolving research and leadership promise to yield transformative solutions that will benefit countless patients worldwide.

Publication

1. Title: Neurobiological alteration in agitation in Alzheimer’s disease and possible interventions
Author(s): Rao, Jagadeesh S.; Tangarife, Maria Alejandra; Mukunda, Ram
Year: 2024

2. Title: Effects of chronic clozapine administration on markers of arachidonic acid cascade and synaptic integrity in rat brain
Author(s): Kim, Hyung-Wook; Cheon, Yewon; Modi, Hiren R.; Rapoport, Stanley I.; Rao, Jagadeesh S.
Year: 2012

3. Title: Epigenetic modifications in frontal cortex from Alzheimer’s disease and bipolar disorder patients
Author(s): Rao, J. S.; Keleshian, V. L.; Klein, S.; Rapoport, S. I.
Year: 2012

4. Title: Gabapentin’s minimal action on markers of rat brain arachidonic acid metabolism agrees with its inefficacy against bipolar disorder
Author(s): Reese, Edmund A.; Cheon, Yewon; Ramadan, Epolia; Kim, Hyung-Wook; Chang, Lisa; Rao, Jagadeesh S.; Rapoport, Stanley I.; Taha, Ameer Y.
Year: 2012

5. Title: Lamotrigine blocks NMDA receptor-initiated arachidonic acid signalling in rat brain: implications for its efficacy in bipolar disorder
Author(s): Ramadan, Epolia; Basselin, Mireille; Rao, Jagadeesh S.; Chang, Lisa; Chen, Mei; Ma, Kaizong; Rapoport, Stanley I.
Year: 2012

6. Title: Altered Expression of G-protein subunits and GRKs in Alzheimer’s Disease
Author(s): Reese, Edmund A.; Kim, Hyung-Wook; Rapoport, Stanley I.; Rao, Jagadeesh S.
Year: 2011

7. Title: Chronic olanzapine treatment decreases arachidonic acid turnover and prostaglandin E₂ concentration in rat brain
Author(s): Cheon, Yewon; Park, Jee-Young; Modi, Hiren R.; Kim, Hyung-Wook; Lee, Ho-Joo; Chang, Lisa; Rao, Jagadeesh S.; Rapoport, Stanley I.
Year: 2011

8. Title: Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain
Author(s): Kim, Hyung-Wook; Rao, Jagadeesh S.; Rapoport, Stanley I.; Igarashi, Miki
Year: 2011

9. Title: Disturbed Choline Plasmalogen and Phospholipid Fatty Acid Concentrations in Alzheimer’s Disease Prefrontal Cortex
Author(s): Igarashi, Miki; Ma, Kaizong; Gao, Fei; Kim, Hyung-Wook; Rapoport, Stanley I.; Rao, Jagadeesh S.
Year: 2011

10. Title: Olanzapine Decreases Brain Arachidonic Acid (AA) Metabolism in Rats by Reducing Plasma Availability of AA
Author(s): Cheon, Yewon; Modi, Hiren R.; Park, Jee-Young; Kim, Hyung-Wook; Chang, Lisa; Rao, Jagadeesh S.; Rapoport, Stanley I.
Year: 2011

✅Conclusion

Dr. Rao’s career reflects a powerful blend of scientific innovation, regulatory excellence, and clinical insight. His dedication to developing safe and effective neurological therapeutics has significantly advanced the field of translational medicine. As a leader, mentor, and researcher, his ongoing work continues to influence modern approaches to treating complex brain disorders, setting a high standard for future neuropharmacological research and therapeutic innovation.