Mohamad-Reza Aghanoori | Neurodegenerative Disorders | Best Researcher Award

Dr. Mohamad-Reza Aghanoori | Neurodegenerative Disorders | Best Researcher Award

Dr. Mohamad-Reza Aghanoori, National Institute of Genetic Engineering and Biotechnology,  Iran.

Dr. Mohamad-Reza Aghanouri is a distinguished neuroscientist and molecular medicine expert whose academic journey spans Iran and Canada. Beginning with foundational training in genetics and human biology, he has advanced into a dynamic career focused on translational neuroscience, particularly the genetic regulation of neurodevelopmental and neurodegenerative disorders. His doctoral and postdoctoral research have contributed significant insights into insulin/IGF-1 signaling, mitochondrial function, and gene expression related to autism and diabetic neuropathy.

Profile

Google Scholar

🎓 Early Academic Pursuits

Mohamad-Reza Aghanouri embarked on his academic journey with a B.Sc. in Cellular and Molecular Biology–Genetics from Shahid Chamran University of Ahvaz, Iran, in 2009. His keen interest in the intricate mechanics of human biology led him to pursue an M.Sc. in Human Genetics at Shiraz University of Medical Sciences, where he explored non-invasive techniques for early sex determination through free fetal DNA analysis. His growing passion for neuroscience and genetics culminated in a Ph.D. from the University of Manitoba, Canada, where he studied at the Department of Pharmacology and Therapeutics and the Division of Neurodegenerative Disorders. His doctoral thesis, focused on insulin/IGF-1 regulation of mitochondrial function in diabetic neuropathy, laid a strong foundation for a dynamic career in translational neurogenetics.

🧬 Professional Endeavors in Translational Neuroscience

Dr. Aghanouri’s postdoctoral work reflects a robust engagement with translational neuroscience and molecular medicine. From 2019 to 2024, he served as a postdoctoral fellow at the Department of Medical Genetics, Cumming School of Medicine, University of Calgary, under the mentorship of Dr. Guang Yang. His research investigated translational regulation of genes implicated in brain development, especially in autism spectrum disorders and rare neurodevelopmental conditions. Prior to that, he worked with Prof. Paul Fernyhough in Winnipeg, Canada, where he examined the role of IGF-1 in ATP production in sensory neurons under diabetic stress conditions. His diverse experience also includes a pivotal R&D advisory role at Roya Bio Gene Company in Tehran, showcasing his versatility across both academic and industrial biosciences.

🔬 Contributions and Research Focus

Dr. Aghanouri’s research contributions bridge the realms of neurodevelopment, metabolism, and genetic regulation. He has delved into the complex interplay between growth factors like IGF-1 and mitochondrial dynamics, particularly in relation to diabetic neuropathy. At the University of Calgary, his postdoctoral investigations explored the molecular pathways influencing neurodevelopmental disorders, positioning his work at the intersection of genomics and neuroscience. His methodological expertise spans cellular models, gene expression analysis, and translational bioinformatics, underscoring a commitment to discovering mechanisms that translate molecular findings into therapeutic insights.

🏆 Accolades and Recognition

Over the course of his academic and research career, Dr. Aghanouri has amassed a commendable list of honors. He received the prestigious CIHR postdoctoral fellowship (CA$40,000 annually, plus research allowance), along with additional fellowships from the Alberta Children’s Hospital Research Institute and the Cumming School of Medicine. Notably, he clinched first place in the Striking Image Competition at the University of Calgary and was honored by the BoniadMelliNokhbegan Foundation for his exceptional research talent. He has also earned multiple research grants from Iranian institutions in 2023 and 2024, reflecting his cross-border research impact and trust among funding bodies.

📚 Institutional Leadership and Influence

In 2024, Dr. Aghanouri was appointed as the Head of the Library, Documentation, Scientometrics, and Publication Center at the National Institute of Genetic Engineering and Biotechnology (NIGEB) in Tehran. He also holds a faculty position in the Department of Molecular Medicine at NIGEB. These roles position him as a key academic leader in Iran’s scientific community, where he not only continues his research but also shapes institutional research strategies, publication ethics, and scientific communication infrastructures. His work contributes significantly to Iran’s national bioscience and health research priorities.

🌍 Impact and Global Engagement

With academic roots in Iran and a decade of research training in Canada, Dr. Aghanouri exemplifies international scientific collaboration. His work addresses global health concerns, such as diabetes-induced neuropathies and neurodevelopmental disorders like autism, thus resonating with both clinical and scientific audiences worldwide. Through his active participation in conferences, poster competitions, and collaborative projects, he serves as a bridge between Iranian biotechnology advancements and the international research community.

🔮 Legacy and Future Contributions

Looking ahead, Dr. Aghanouri is poised to further advance the fields of molecular neurogenetics and translational medicine. His ongoing research is expected to uncover novel genetic mechanisms underlying brain development and metabolic dysfunctions. As a faculty member and research leader, he is mentoring the next generation of Iranian scientists while enhancing the global understanding of complex neurological diseases. His integrated approach to research, policy, and education ensures that his legacy will be one of both scientific innovation and institutional transformation.

Publication

 

  • Betulin and its derivatives as novel compounds with different pharmacological effects
    S Amiri, S Dastghaib, M Ahmadi, P Mehrbod, F Khadem, H Behrouj, …
    2020

 

  • Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury
    A Stamenkovic, KA O’Hara, DC Nelson, TG Maddaford, AL Edel, …
    2021

 

  • Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes
    MR Aghanoori, DR Smith, S Shariati-Ievari, A Ajisebutu, A Nguyen, …
    2019

 

  • The ER stress/UPR axis in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
    M Aghaei, S Dastghaib, S Aftabi, MR Aghanoori, J Alizadeh, P Mokarram, …
    2020

 

  • MiRNA molecular profiles in human medical conditions: Connecting lung cancer and lung development phenomena
    MR Aghanoori, B Mirzaei, M Tavallaei
    2014

 

  • Mechanisms targeting the unfolded protein response in asthma
    S Dastghaib, PS Kumar, S Aftabi, G Damera, A Dalvand, A Sepanjnia, …
    2021

 

  • Nucleocytoplasmic transport of the RNA-binding protein CELF2 regulates neural stem cell fates
    MJ MacPherson, SL Erickson, D Kopp, P Wen, MR Aghanoori, S Kedia, …
    2021

 

  • CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E1*3 Allele Frequencies in Iranian Populations
    GM Shahriary, H Galehdari, A Jalali, F Zanganeh, SMR Alavi, …
    2012

 

  • Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats
    MR Aghanoori, DR Smith, SR Chowdhury, MG Sabbir, NA Calcutt, …
    2017

 

  • CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth
    MR Aghanoori, P Agarwal, E Gauvin, RS Nagalingam, R Bonomo, …
    2022

✅ Conclusion

Dr. Aghanouri stands out as a versatile and impactful scientist whose contributions to neuroscience and genetic medicine hold promise for both understanding and treating complex neurological conditions. His career reflects a strong blend of academic excellence, international collaboration, and leadership in research development. As he continues to build bridges between Iranian and global biosciences, his future work is expected to leave a lasting legacy in molecular neuroscience and translational medicine.

 

Mustafa Nazıroğlu | Cellular Neuroscience | Neuroscience Research Excellence Award

Prof. Mustafa Nazıroğlu | Cellular Neuroscience | Neuroscience Research Excellence Award

Prof. Mustafa Nazıroğlu,  Suleyman Demirel University, Turkey.

Professor Mustafa Nazıroğlu is a distinguished scholar with dual doctorates in Physiology and Neuroscience. Beginning his academic journey at Fırat University and advancing to leadership roles at Süleyman Demirel University, he has become a global authority in the fields of oxidative stress, calcium signaling, and TRP ion channels. His research portfolio includes over 270 peer-reviewed articles and thousands of citations, showcasing a profound impact on cellular neuroscience. Beyond research, he has led major international congresses, served on editorial boards of top journals, and has been honored with numerous awards and fellowships in Europe, Asia, and North America.

Profile

Orcid

 

🎓 Early Academic Pursuits

Professor Mustafa Nazıroğlu embarked on his academic journey with a degree from the Faculty of Veterinary Medicine at Fırat University in 1991. Driven by a profound curiosity for physiological mechanisms, he pursued a Ph.D. in Physiology at the same institution, which he completed between 1992 and 1996. His academic ambitions later led him to earn a second Ph.D. in Neuroscience from Süleyman Demirel University (SDU) in 2018, reflecting his commitment to interdisciplinary scholarship and continuous learning.

🧠 Professional Endeavors in Neuroscience and Biophysics

Currently, Professor Nazıroğlu holds the position of Head of the Department of Biophysics and Neuroscience at SDU Medical Faculty. His professional path has been shaped by a deep dedication to academic leadership, having served in several key roles including department head, director of the Neuroscience Research Centre (NOROBAM), and chair of numerous international scientific congresses. Notably, he has successfully organized the biennial International World Congress of Oxidative Stress, Calcium Signalling and TRP Channels from 2006 to 2020, as well as the International Brain Research School series from 2015 to 2024. His influence has also reached global platforms, including service on the organizing committee for the TEMA-14 Congress in Hubei, China, in 2011.

🔬 Contributions and Research Focus

A prolific researcher, Professor Nazıroğlu has significantly advanced our understanding of oxidative stress, calcium signaling, apoptosis, and ion channel (TRP) physiology. His scientific output includes 274 international research articles, 19 review papers, and six book chapters, collectively amassing over 11,500 citations and earning him a Scopus h-index of 59. He has also contributed as an editorial and reviewing member for leading journals such as Biological Trace Element Research, Scientific Reports (Nature Publishing), Frontiers in Physiology, and Current Neuropharmacology, among others. His research has bridged cellular neuroscience with therapeutic strategies, making him a vital contributor to the global scientific discourse.

🏅 Accolades and Recognition

Throughout his career, Professor Nazıroğlu has received numerous national and international honors, celebrating his scientific achievements and global engagement. These include the NATO Research Fellowship (Germany), the Alexander von Humboldt Fellowship (Germany), and the Young Investigative Scientist Award (USA). He has also been recognized by the Turkish Scientific and Technological Research Council (TÜBİTAK), the Howard Hughes Medical Institute (USA), and was the recipient of the prestigious Khwarizmi International Award (Iran). His visiting professorships at institutions in the UK, Qatar, and Japan further underscore his international reputation and collaboration.

🌍 Impact and Influence

Professor Nazıroğlu’s impact extends beyond academic publishing and conference organization. As a mentor, speaker, and panel member, he has shaped the careers of young neuroscientists and fostered a collaborative global network of researchers in calcium signaling and oxidative biology. His participation in expert advisory boards and scientific panels illustrates the depth of his influence on both research policy and biomedical innovation.

📘 Legacy of Knowledge

With over three decades dedicated to science and education, Professor Nazıroğlu has built a lasting legacy grounded in scientific rigor and visionary leadership. His conferences and educational programs, especially the International Brain Research School, have become cornerstone events for knowledge exchange in neuroscience. He has laid a strong foundation for future advancements in TRP channel research and neurophysiology.

🚀 Future Contributions and Vision

Looking forward, Professor Nazıroğlu continues to guide critical research on cellular responses to oxidative stress and ion channel modulation. His forward-thinking approach, combined with an inclusive scientific philosophy, ensures that he remains a leading voice in shaping the next era of biomedical research. With ongoing collaborative projects and mentorship of emerging scholars, his work is poised to influence both clinical and theoretical frontiers for years to come.

Publication

 

  • Title: Vitamin D Supplementation Modulates Blood and Tissue Zinc, Liver Glutathione and Blood Biochemical Parameters in Diabetic Rats on a Zinc-Deficient Diet
    Authors: Kechrid, Z.; Hamdiken, M.; Nazıroğlu, M.; Flores-Arce, M.
    Year: 2023

 

  • Title: Low molecular weight heparin treatment reduced apoptosis and oxidative cytotoxicity in the thrombocytes of patients with recurrent pregnancy loss and thrombophilia: Involvements of TRPM2 and TRPV1 channels
    Authors: Dal, Y.; Nazıroğlu, M.; Özkaya, M.O.
    Year: 2023

 

  • Title: NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine
    Authors: Kenan Yıldızhan; Mustafa Nazıroğlu
    Year: 2023

 

  • Title: Honey bee venom melittin increases the oxidant activity of cisplatin and kills human glioblastoma cells by stimulating the TRPM2 channel
    Authors: Kemal Ertilav; Mustafa Nazıroğlu
    Year: 2023

 

  • Title: Silver nanoparticles potentiate antitumor and oxidant actions of cisplatin via the stimulation of TRPM2 channel in glioblastoma tumor cells
    Authors: Yener Akyuva; Mustafa Nazıroğlu
    Year: 2023

 

  • Title: A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol
    Author: Nazıroğlu, M.
    Year: 2022

 

  • Title: Amantadine Attenuated Hypoxia-Induced Mitochondrial Oxidative Neurotoxicity, Apoptosis, and Inflammation via the Inhibition of TRPM2 and TRPV4 Channels
    Authors: Öcal, Ö.; Coşar, A.; Nazıroğlu, M.
    Year: 2022

 

  • Title: Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells
    Authors: Öcal, Ö.; Nazıroğlu, M.
    Year: 2022

 

  • Title: Paclitaxel Promotes Oxidative Stress–Mediated Human Laryngeal Squamous Tumor Cell Death through the Stimulation of Calcium and Zinc Signaling Pathways: No Synergic Action of Melatonin
    Authors: Kumbul, Y.Ç.; Nazıroğlu, M.
    Year: 2022

 

  • Title: Protective role of selenium on MPP⁺ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells
    Authors: Yıldızhan, K.; Nazıroğlu, M.
    Year: 2022

 

🧾 Conclusion

Through an outstanding blend of academic excellence, innovative research, and global collaboration, Professor Nazıroğlu has carved a legacy as a leading figure in neuroscience and biophysics. His efforts in organizing international platforms and mentoring young scientists reflect a career committed to advancing knowledge and fostering global scientific networks. With continued contributions and visionary leadership, he remains a driving force in shaping the future of cellular neurophysiology and therapeutic discovery.