Hongrui Meng | Neurodegenerative disease | Excellence in Research Award

Prof. Dr. Hongrui Meng | Neurodegenerative disease | Excellence in Research Award

Prof. Dr. Hongrui Meng,  Institute of Neuroscience, Soochow University, China.

Dr. Hongrui Meng is a highly accomplished neuroscientist whose academic path began with a Ph.D. in Behavioural Neuroscience from Hamamatsu University School of Medicine in Japan. He later conducted postdoctoral research in molecular neurobiology and human genetics at Juntendo University, Tokyo. Currently a professor at the Institute of Neuroscience, Soochow University, Dr. Meng leads a research team dedicated to uncovering the molecular and mitochondrial mechanisms underlying Parkinson’s disease and ALS. His work spans high-impact research projects funded by JSPS, NSFC, and other prestigious bodies. In addition to numerous scientific publications, he has contributed to diagnostic innovation through patented miRNA detection methods. His influence extends beyond academia through translational applications such as wearable technologies for Parkinson’s symptom monitoring.

Profile

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🎓 Early Academic Pursuits

Dr. Hongrui Meng began his distinguished academic journey in the field of neuroscience by earning his Ph.D. in Behavioural Neuroscience from the prestigious Hamamatsu University School of Medicine in Japan. His early education and training laid a strong foundation in experimental neuroscience, with a focus on the behavioral manifestations of neurodegenerative conditions. These formative years not only sharpened his scientific curiosity but also equipped him with the cross-disciplinary expertise to address complex neurological questions.

🧠 Professional Endeavors

Following his doctoral studies, Dr. Meng advanced his specialization through postdoctoral training in molecular neurobiology and human genetics at Juntendo University in Tokyo. There, he immersed himself in high-level research focusing on the genetic underpinnings of neurological disorders. His competence and dedication soon earned him a faculty appointment as an Assistant Professor in the Department of Research for Neurodegenerative Diseases and Dementia. His professional arc reached a significant milestone in 2020 when he was promoted to Full Professor and moved to the Institute of Neuroscience at Soochow University, where he now leads the Laboratory of Molecular Neurology.

🧬 Contributions and Research Focus

Dr. Meng’s scientific contributions center on the molecular mechanisms of Parkinson’s disease and amyotrophic lateral sclerosis (ALS). His research bridges mitochondrial dysfunction, alpha-synuclein aggregation, and neurodegeneration. He has completed pivotal studies supported by the Japan Society for the Promotion of Science and the Takeda Pharmaceutical Foundation, delving into the role of CHCHD2 gene mutations and mitochondrial pathways. His ongoing projects funded by the National Natural Science Foundation of China (NSFC) explore mitochondrial unfolded protein responses (mtUPR), while another innovative project in Suzhou focuses on wearable technology for monitoring Parkinson’s disease symptoms—demonstrating his commitment to translational and patient-centered neuroscience.

🔬 Innovation and Scientific Output

A notable innovator, Dr. Meng has made strides in molecular diagnostic technologies. His work has led to the development of high-throughput RT-qPCR-based methods for detecting primary and precursor miRNAs, contributing to enhanced genetic analysis of neurodegenerative disorders. He holds a patent granted in South Africa and another under process in China, underscoring his role at the intersection of research and technology. Furthermore, his publications in highly regarded journals like Current Issues in Molecular Biology and Cell Communication and Signaling reflect a consistent record of impactful findings that inform both fundamental neuroscience and clinical approaches.

🏅 Accolades and Recognition

Dr. Meng’s ascent in the academic community has been marked by numerous grants, including multiple from the JSPS and NSFC, attesting to the trust placed in his research vision by top funding bodies. While a formal list of awards may be under-documented, his rapid progression from postdoctoral fellow to professor and research team leader in less than a decade speaks volumes about his recognition among peers and institutional leadership. His leadership in multi-disciplinary and international collaborations is an implicit accolade of his scientific reliability and visionary perspective.

🌍 Impact and Influence

Through his groundbreaking work on mitochondrial mechanisms and neurodegeneration, Dr. Meng is helping to reshape current understanding of Parkinson’s disease pathophysiology. His investigations into alpha-synucleinopathy and microglial disruption have provided fresh insights into cellular degeneration and neuroimmune interactions. Beyond academia, his involvement in developing wearable diagnostic tools highlights his drive to impact patient lives directly. As a consultant on neuroprotective treatments such as PD-018/19, he bridges the academic and pharmaceutical worlds to accelerate therapeutic discovery.

🔮 Legacy and Future Contributions

Looking forward, Dr. Meng is poised to be a leading figure in neurogenetic diagnostics and therapeutic innovation. His laboratory at Soochow University serves as an incubator for future discoveries in neurodegenerative disease mechanisms, and his continued work in mitochondrial research promises to inform emerging therapies. With a growing publication record, international patents, and a robust research pipeline, Dr. Meng’s legacy will be one of bridging basic neuroscience with clinical application—paving the way for novel interventions and a better understanding of brain disorders in the molecular era.

Publication

 

  • Title: Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency
    Authors: Xiang Long, Yijie Wang, Hongrui Meng
    Year: 2025

 

  • Title: Transcriptomic analysis of lipid metabolism genes in Alzheimer’s disease: highlighting pathological outcomes and compartmentalized immune status
    Authors: Sun Y., Zhang Y., Jiang M., Long X., Miao Y., Du H., Zhang T., Meng H., Ma X.
    Year: 2024

 

  • Title: CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
    Authors: Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita et al.
    Year: 2024

 

  • Title: TDP-43 mutations-induced defects in miRNA biogenesis and cytotoxicity by differentially obstructing Dicer activity in Drosophila and in vitro
    Authors: Xiang Long, Mengni Jiang, Yongzhen Miao, Huanhuan Du, Ting Zhang, Zhuoya Ma, Jiao Li, Chunfeng Liu, Hongrui Meng
    Year: 2024

 

  • Title: A Simple Technique to Assay Locomotor Activity in Drosophila
    Authors: Long X., Du H., Jiang M., Meng H.
    Year: 2023

 

  • Title: Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression
    Authors: Meng H.-R., Suenaga T., Edamura M., Nakahara D., Murakami G., Fukuda A., Ishida Y.
    Year: 2021

 

  • Title: Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease
    Authors: Imai Y., Hattori N., Inoshita T., Shiba-Fukushima K., Meng H., Hara K.Y., Sawamura N.
    Year: 2019

 

  • Title: Mutations in CHCHD2 cause α-synuclein aggregation
    Authors: Ikeda A., Nishioka K., Takanashi M., Li Y., Mori A., Okuzumi A., Izawa N., Ishikawa K.-I., Funayama M., Imai Y. et al.
    Year: 2019

 

  • Title: Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling
    Authors: Mori A., Hatano T., Koinuma T., Kubo S.-I., Spratt S., Yamashita C., Okuzumi A., Imai Y., Hattori N., Inoshita T. et al.
    Year: 2019

 

  • Title: Twin CHCH proteins, CHCHD2, and CHCHD10: Key molecules of Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
    Authors: Imai Y., Hattori N., Meng H., Shiba-Fukushima K.
    Year: 2019

 

🧾 Conclusion

Dr. Hongrui Meng’s career reflects a dynamic blend of academic excellence, molecular research innovation, and translational neuroscience. His scientific endeavors have not only enriched the understanding of neurodegenerative diseases but have also paved the way for novel diagnostic and therapeutic strategies. With a growing portfolio of impactful research, patents, and leadership in neurobiology, Dr. Meng stands out as a driving force in the global fight against neurological disorders. His work promises continued contributions to neuroscience with lasting influence on both scientific knowledge and patient care.

 

Shumao Xu | Neurotechnology | Best Researcher Award

Assoc. Prof. Dr. Shumao Xu | Neurotechnology | Best Researcher Award

Assoc. Prof. Dr.  Shumao Xu, Fudan University, China.

Shumao Xu’s career embodies a fusion of material science, biomedical engineering, and neurotechnology, leading to remarkable advancements in neural interfaces and brain-computer interaction. His extensive research, industry collaborations, and prestigious funding awards highlight his influence in the field. With over 60 high-impact publications and thousands of citations, his work has significantly contributed to neuroengineering, setting the foundation for future innovations.

Profile

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✨ Early Academic Pursuits

Shumao Xu’s journey in academia began with a passion for innovation and exploration in neural interfaces and biomedical engineering. He pursued his Ph.D. at Shanghai Jiao Tong University (SJTU), where he laid the foundation for his research in neural engineering. His early academic years were marked by rigorous studies in material science, bioelectronics, and neurotechnology, setting the stage for his groundbreaking work in neural interfaces. His commitment to excellence led him to postdoctoral training at the prestigious Max Planck Institute for Solid-State Research as an Alexander von Humboldt scholar, followed by further research at Pennsylvania State University and UCLA.

👨‍🎓 Professional Endeavors

Currently an Associate Professor and Principal Investigator at Fudan University’s Institute of Science and Technology for Brain-Inspired Intelligence (ISTBI), Shumao Xu is recognized as a National Overseas Young Talent (2024). His professional trajectory has been defined by his commitment to advancing brain-computer interfaces and neurotechnology. Securing funding from prestigious organizations such as the National Natural Science Foundation of China (NSFC), China Postdoctoral Science Foundation (Innovative Program), and the Shanghai Super Postdoctoral Program, he has spearheaded research that pushes the boundaries of neural engineering.

🧠 Contributions and Research Focus

Shumao Xu has dedicated his research to developing state-of-the-art neural interfaces that revolutionize neurostimulation and brain-computer interactions. His pioneering work includes implantable neural electrodes, non-invasive deep brain stimulation, calcium imaging, and non-genetic optoelectronic neural interfaces. His research extends to the development of soft magnetoelastic energy harvesters, injectable fluorescent neural probes, and triboelectric neurostimulators for self-powered neural systems. His work is crucial in creating biocompatible and energy-efficient neurotechnologies that have the potential to treat neurodegenerative diseases and enhance brain function.

🏆 Accolades and Recognition

With over 60 high-impact publications in renowned journals such as Advanced Materials, Nature Communications, Nano Letters, Matter, and Chem, Shumao Xu has established himself as a leading researcher in neurotechnology. His impressive h-index of 28 and more than 3,300 citations stand as a testament to the significance of his contributions. He has been honored with funding from the NSFC Oversea Young Talent program for his work on injectable fluorescent neural probes and received the Humboldt Foundation’s support for optoelectronic neural modulation. His research has gained international recognition, earning him industry collaborations and consultancy projects.

⚛️ Impact and Influence

Beyond academia, Shumao Xu’s work has practical applications in the medical and technological sectors. His collaborations with leading industry giants, such as Showa Denko and Teijin in Tokyo, Japan, have translated his academic innovations into real-world applications. His research in neural interfaces and brain-computer technologies has the potential to revolutionize treatments for neurological disorders, offering new hope to patients with neurodegenerative diseases. His advancements in self-powered neural stimulation systems have paved the way for sustainable and long-lasting neurotechnologies.

💡 Legacy and Future Contributions

As a visionary in neuroengineering, Shumao Xu continues to shape the future of brain-computer interfaces and neural modulation. His work is not only contributing to academic advancements but also influencing the next generation of researchers and engineers in neurotechnology. His ongoing research projects, including biocompatible neural electrodes and optoelectronic neural modulation, promise to drive innovation in the field. Through his relentless pursuit of scientific breakthroughs, he aims to bridge the gap between neuroscience and technology, ultimately transforming the landscape of brain-computer interaction and neurotherapy.

Publication

  • Artificial intelligence assisted nanogenerator applications

    • Authors: Shumao Xu, Farid Manshaii, Xiao Xiao, Jun Chen

    • Year: 2025

 

  • Advances in 2D materials for wearable biomonitoring

    • Authors: Songyue Chen, Shumao Xu, Xiujun Fan, Xiao Xiao, Zhaoqi Duan, Xun Zhao, Guorui Chen, Yihao Zhou, Jun Chen

    • Year: 2025

 

  • A comprehensive review on the mechanism of contact electrification

    • Authors: J Tian, Y He, F Li, W Peng, Y He, Shumao Xu, F Manshaii, X Xiao, Jun Chen

    • Year: 2025

 

  • Advances in Brain Computer Interface for Amyotrophic Lateral Sclerosis Communication

    • Authors: Yuchun Wang, Yurui Tang, Qianfeng Wang, Minyan Ge, Jinling Wang, Xinyi Cui, Nianhong Wang, Zhijun Bao, Shugeng Chen, Jing Wang et al.

    • Year: 2025

 

  • Tailored Terminal Groups in MXenes for Fast-Charging and Safe Energy Storage

    • Authors: Shumao Xu, Minyan Ge, Weiqiang Zhang, Yuchun Wang, Yurui Tang

    • Year: 2025

 

  • Heart-brain connection: How can heartbeats shape our minds?

    • Authors: Xu Shumao, Scott Kamryn, Manshaii Farid, Chen Jun

    • Year: 2024

  • Injectable Fluorescent Neural Interfaces for Cell-Specific Stimulating and Imaging

    • Authors: Xu Shumao, Xiao Xiao, Manshaii Farid, Chen Jun

    • Year: 2024

 

  • Multiphasic interfaces enabled aero-elastic capacitive pressure sensors

    • Authors: Xu Shumao, Manshaii Farid, Chen Jun

    • Year: 2024

 

  • Reversible metal-ligand coordination for photocontrolled metallopolymer adhesives

    • Authors: Xu Shumao, Manshaii Farid, Chen Guorui, Chen Jun

    • Year: 2024

 

  • Self-Thermal Management in Filtered Selenium-Terminated MXene Films for Flexible Safe Batteries

    • Authors: Pang Xin, Lee Hyunjin, Rong Jingzhi, Zhu Qiaoyu, Xu Shumao

    • Year: 2024

 

🌟 Conclusion

Shumao Xu’s pioneering research and dedication to neural engineering continue to push the boundaries of brain-inspired intelligence and medical advancements. His visionary contributions have paved the way for next-generation neurotechnologies that hold the potential to transform neurological treatments and human-computer interactions. As he continues his groundbreaking research, his legacy will inspire future scientists and engineers, driving forward the possibilities of neurotechnology for years to come.