Prof. Dr. Hongrui Meng | Neurodegenerative disease | Excellence in Research Award

Prof. Dr. Hongrui Meng,  Institute of Neuroscience, Soochow University, China.

Dr. Hongrui Meng is a highly accomplished neuroscientist whose academic path began with a Ph.D. in Behavioural Neuroscience from Hamamatsu University School of Medicine in Japan. He later conducted postdoctoral research in molecular neurobiology and human genetics at Juntendo University, Tokyo. Currently a professor at the Institute of Neuroscience, Soochow University, Dr. Meng leads a research team dedicated to uncovering the molecular and mitochondrial mechanisms underlying Parkinson’s disease and ALS. His work spans high-impact research projects funded by JSPS, NSFC, and other prestigious bodies. In addition to numerous scientific publications, he has contributed to diagnostic innovation through patented miRNA detection methods. His influence extends beyond academia through translational applications such as wearable technologies for Parkinson’s symptom monitoring.

Profile

Orcid

🎓 Early Academic Pursuits

Dr. Hongrui Meng began his distinguished academic journey in the field of neuroscience by earning his Ph.D. in Behavioural Neuroscience from the prestigious Hamamatsu University School of Medicine in Japan. His early education and training laid a strong foundation in experimental neuroscience, with a focus on the behavioral manifestations of neurodegenerative conditions. These formative years not only sharpened his scientific curiosity but also equipped him with the cross-disciplinary expertise to address complex neurological questions.

🧠 Professional Endeavors

Following his doctoral studies, Dr. Meng advanced his specialization through postdoctoral training in molecular neurobiology and human genetics at Juntendo University in Tokyo. There, he immersed himself in high-level research focusing on the genetic underpinnings of neurological disorders. His competence and dedication soon earned him a faculty appointment as an Assistant Professor in the Department of Research for Neurodegenerative Diseases and Dementia. His professional arc reached a significant milestone in 2020 when he was promoted to Full Professor and moved to the Institute of Neuroscience at Soochow University, where he now leads the Laboratory of Molecular Neurology.

🧬 Contributions and Research Focus

Dr. Meng’s scientific contributions center on the molecular mechanisms of Parkinson’s disease and amyotrophic lateral sclerosis (ALS). His research bridges mitochondrial dysfunction, alpha-synuclein aggregation, and neurodegeneration. He has completed pivotal studies supported by the Japan Society for the Promotion of Science and the Takeda Pharmaceutical Foundation, delving into the role of CHCHD2 gene mutations and mitochondrial pathways. His ongoing projects funded by the National Natural Science Foundation of China (NSFC) explore mitochondrial unfolded protein responses (mtUPR), while another innovative project in Suzhou focuses on wearable technology for monitoring Parkinson’s disease symptoms—demonstrating his commitment to translational and patient-centered neuroscience.

🔬 Innovation and Scientific Output

A notable innovator, Dr. Meng has made strides in molecular diagnostic technologies. His work has led to the development of high-throughput RT-qPCR-based methods for detecting primary and precursor miRNAs, contributing to enhanced genetic analysis of neurodegenerative disorders. He holds a patent granted in South Africa and another under process in China, underscoring his role at the intersection of research and technology. Furthermore, his publications in highly regarded journals like Current Issues in Molecular Biology and Cell Communication and Signaling reflect a consistent record of impactful findings that inform both fundamental neuroscience and clinical approaches.

🏅 Accolades and Recognition

Dr. Meng’s ascent in the academic community has been marked by numerous grants, including multiple from the JSPS and NSFC, attesting to the trust placed in his research vision by top funding bodies. While a formal list of awards may be under-documented, his rapid progression from postdoctoral fellow to professor and research team leader in less than a decade speaks volumes about his recognition among peers and institutional leadership. His leadership in multi-disciplinary and international collaborations is an implicit accolade of his scientific reliability and visionary perspective.

🌍 Impact and Influence

Through his groundbreaking work on mitochondrial mechanisms and neurodegeneration, Dr. Meng is helping to reshape current understanding of Parkinson’s disease pathophysiology. His investigations into alpha-synucleinopathy and microglial disruption have provided fresh insights into cellular degeneration and neuroimmune interactions. Beyond academia, his involvement in developing wearable diagnostic tools highlights his drive to impact patient lives directly. As a consultant on neuroprotective treatments such as PD-018/19, he bridges the academic and pharmaceutical worlds to accelerate therapeutic discovery.

🔮 Legacy and Future Contributions

Looking forward, Dr. Meng is poised to be a leading figure in neurogenetic diagnostics and therapeutic innovation. His laboratory at Soochow University serves as an incubator for future discoveries in neurodegenerative disease mechanisms, and his continued work in mitochondrial research promises to inform emerging therapies. With a growing publication record, international patents, and a robust research pipeline, Dr. Meng’s legacy will be one of bridging basic neuroscience with clinical application—paving the way for novel interventions and a better understanding of brain disorders in the molecular era.

Publication

 

• Title: Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency
  Authors: Xiang Long, Yijie Wang, Hongrui Meng
  Year: 2025

 

• Title: Transcriptomic analysis of lipid metabolism genes in Alzheimer’s disease: highlighting pathological outcomes and compartmentalized immune status
  Authors: Sun Y., Zhang Y., Jiang M., Long X., Miao Y., Du H., Zhang T., Meng H., Ma X.
  Year: 2024

 

• Title: CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
  Authors: Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita et al.
  Year: 2024

 

• Title: TDP-43 mutations-induced defects in miRNA biogenesis and cytotoxicity by differentially obstructing Dicer activity in Drosophila and in vitro
  Authors: Xiang Long, Mengni Jiang, Yongzhen Miao, Huanhuan Du, Ting Zhang, Zhuoya Ma, Jiao Li, Chunfeng Liu, Hongrui Meng
  Year: 2024

 

• Title: A Simple Technique to Assay Locomotor Activity in Drosophila
  Authors: Long X., Du H., Jiang M., Meng H.
  Year: 2023

 

• Title: Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression
  Authors: Meng H.-R., Suenaga T., Edamura M., Nakahara D., Murakami G., Fukuda A., Ishida Y.
  Year: 2021

 

• Title: Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease
  Authors: Imai Y., Hattori N., Inoshita T., Shiba-Fukushima K., Meng H., Hara K.Y., Sawamura N.
  Year: 2019

 

• Title: Mutations in CHCHD2 cause α-synuclein aggregation
  Authors: Ikeda A., Nishioka K., Takanashi M., Li Y., Mori A., Okuzumi A., Izawa N., Ishikawa K.-I., Funayama M., Imai Y. et al.
  Year: 2019

 

• Title: Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling
  Authors: Mori A., Hatano T., Koinuma T., Kubo S.-I., Spratt S., Yamashita C., Okuzumi A., Imai Y., Hattori N., Inoshita T. et al.
  Year: 2019

 

• Title: Twin CHCH proteins, CHCHD2, and CHCHD10: Key molecules of Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
  Authors: Imai Y., Hattori N., Meng H., Shiba-Fukushima K.
  Year: 2019

 

🧾 Conclusion

Dr. Hongrui Meng’s career reflects a dynamic blend of academic excellence, molecular research innovation, and translational neuroscience. His scientific endeavors have not only enriched the understanding of neurodegenerative diseases but have also paved the way for novel diagnostic and therapeutic strategies. With a growing portfolio of impactful research, patents, and leadership in neurobiology, Dr. Meng stands out as a driving force in the global fight against neurological disorders. His work promises continued contributions to neuroscience with lasting influence on both scientific knowledge and patient care.