Hongrui Meng | Neurodegenerative disease | Excellence in Research Award

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Prof. Dr. Hongrui Meng | Neurodegenerative disease | Excellence in Research Award

Prof. Dr. Hongrui Meng,  Institute of Neuroscience, Soochow University, China.

Dr. Hongrui Meng is a highly accomplished neuroscientist whose academic path began with a Ph.D. in Behavioural Neuroscience from Hamamatsu University School of Medicine in Japan. He later conducted postdoctoral research in molecular neurobiology and human genetics at Juntendo University, Tokyo. Currently a professor at the Institute of Neuroscience, Soochow University, Dr. Meng leads a research team dedicated to uncovering the molecular and mitochondrial mechanisms underlying Parkinson’s disease and ALS. His work spans high-impact research projects funded by JSPS, NSFC, and other prestigious bodies. In addition to numerous scientific publications, he has contributed to diagnostic innovation through patented miRNA detection methods. His influence extends beyond academia through translational applications such as wearable technologies for Parkinson’s symptom monitoring.

Profile

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🎓 Early Academic Pursuits

Dr. Hongrui Meng began his distinguished academic journey in the field of neuroscience by earning his Ph.D. in Behavioural Neuroscience from the prestigious Hamamatsu University School of Medicine in Japan. His early education and training laid a strong foundation in experimental neuroscience, with a focus on the behavioral manifestations of neurodegenerative conditions. These formative years not only sharpened his scientific curiosity but also equipped him with the cross-disciplinary expertise to address complex neurological questions.

🧠 Professional Endeavors

Following his doctoral studies, Dr. Meng advanced his specialization through postdoctoral training in molecular neurobiology and human genetics at Juntendo University in Tokyo. There, he immersed himself in high-level research focusing on the genetic underpinnings of neurological disorders. His competence and dedication soon earned him a faculty appointment as an Assistant Professor in the Department of Research for Neurodegenerative Diseases and Dementia. His professional arc reached a significant milestone in 2020 when he was promoted to Full Professor and moved to the Institute of Neuroscience at Soochow University, where he now leads the Laboratory of Molecular Neurology.

🧬 Contributions and Research Focus

Dr. Meng’s scientific contributions center on the molecular mechanisms of Parkinson’s disease and amyotrophic lateral sclerosis (ALS). His research bridges mitochondrial dysfunction, alpha-synuclein aggregation, and neurodegeneration. He has completed pivotal studies supported by the Japan Society for the Promotion of Science and the Takeda Pharmaceutical Foundation, delving into the role of CHCHD2 gene mutations and mitochondrial pathways. His ongoing projects funded by the National Natural Science Foundation of China (NSFC) explore mitochondrial unfolded protein responses (mtUPR), while another innovative project in Suzhou focuses on wearable technology for monitoring Parkinson’s disease symptoms—demonstrating his commitment to translational and patient-centered neuroscience.

🔬 Innovation and Scientific Output

A notable innovator, Dr. Meng has made strides in molecular diagnostic technologies. His work has led to the development of high-throughput RT-qPCR-based methods for detecting primary and precursor miRNAs, contributing to enhanced genetic analysis of neurodegenerative disorders. He holds a patent granted in South Africa and another under process in China, underscoring his role at the intersection of research and technology. Furthermore, his publications in highly regarded journals like Current Issues in Molecular Biology and Cell Communication and Signaling reflect a consistent record of impactful findings that inform both fundamental neuroscience and clinical approaches.

🏅 Accolades and Recognition

Dr. Meng’s ascent in the academic community has been marked by numerous grants, including multiple from the JSPS and NSFC, attesting to the trust placed in his research vision by top funding bodies. While a formal list of awards may be under-documented, his rapid progression from postdoctoral fellow to professor and research team leader in less than a decade speaks volumes about his recognition among peers and institutional leadership. His leadership in multi-disciplinary and international collaborations is an implicit accolade of his scientific reliability and visionary perspective.

🌍 Impact and Influence

Through his groundbreaking work on mitochondrial mechanisms and neurodegeneration, Dr. Meng is helping to reshape current understanding of Parkinson’s disease pathophysiology. His investigations into alpha-synucleinopathy and microglial disruption have provided fresh insights into cellular degeneration and neuroimmune interactions. Beyond academia, his involvement in developing wearable diagnostic tools highlights his drive to impact patient lives directly. As a consultant on neuroprotective treatments such as PD-018/19, he bridges the academic and pharmaceutical worlds to accelerate therapeutic discovery.

🔮 Legacy and Future Contributions

Looking forward, Dr. Meng is poised to be a leading figure in neurogenetic diagnostics and therapeutic innovation. His laboratory at Soochow University serves as an incubator for future discoveries in neurodegenerative disease mechanisms, and his continued work in mitochondrial research promises to inform emerging therapies. With a growing publication record, international patents, and a robust research pipeline, Dr. Meng’s legacy will be one of bridging basic neuroscience with clinical application—paving the way for novel interventions and a better understanding of brain disorders in the molecular era.

Publication

 

  • Title: Dicer Is Involved in Cytotoxicity and Motor Impairment Induced by TBPH Deficiency
    Authors: Xiang Long, Yijie Wang, Hongrui Meng
    Year: 2025

 

  • Title: Transcriptomic analysis of lipid metabolism genes in Alzheimer’s disease: highlighting pathological outcomes and compartmentalized immune status
    Authors: Sun Y., Zhang Y., Jiang M., Long X., Miao Y., Du H., Zhang T., Meng H., Ma X.
    Year: 2024

 

  • Title: CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
    Authors: Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita et al.
    Year: 2024

 

  • Title: TDP-43 mutations-induced defects in miRNA biogenesis and cytotoxicity by differentially obstructing Dicer activity in Drosophila and in vitro
    Authors: Xiang Long, Mengni Jiang, Yongzhen Miao, Huanhuan Du, Ting Zhang, Zhuoya Ma, Jiao Li, Chunfeng Liu, Hongrui Meng
    Year: 2024

 

  • Title: A Simple Technique to Assay Locomotor Activity in Drosophila
    Authors: Long X., Du H., Jiang M., Meng H.
    Year: 2023

 

  • Title: Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression
    Authors: Meng H.-R., Suenaga T., Edamura M., Nakahara D., Murakami G., Fukuda A., Ishida Y.
    Year: 2021

 

  • Title: Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease
    Authors: Imai Y., Hattori N., Inoshita T., Shiba-Fukushima K., Meng H., Hara K.Y., Sawamura N.
    Year: 2019

 

  • Title: Mutations in CHCHD2 cause α-synuclein aggregation
    Authors: Ikeda A., Nishioka K., Takanashi M., Li Y., Mori A., Okuzumi A., Izawa N., Ishikawa K.-I., Funayama M., Imai Y. et al.
    Year: 2019

 

  • Title: Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling
    Authors: Mori A., Hatano T., Koinuma T., Kubo S.-I., Spratt S., Yamashita C., Okuzumi A., Imai Y., Hattori N., Inoshita T. et al.
    Year: 2019

 

  • Title: Twin CHCH proteins, CHCHD2, and CHCHD10: Key molecules of Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
    Authors: Imai Y., Hattori N., Meng H., Shiba-Fukushima K.
    Year: 2019

 

🧾 Conclusion

Dr. Hongrui Meng’s career reflects a dynamic blend of academic excellence, molecular research innovation, and translational neuroscience. His scientific endeavors have not only enriched the understanding of neurodegenerative diseases but have also paved the way for novel diagnostic and therapeutic strategies. With a growing portfolio of impactful research, patents, and leadership in neurobiology, Dr. Meng stands out as a driving force in the global fight against neurological disorders. His work promises continued contributions to neuroscience with lasting influence on both scientific knowledge and patient care.

 

Joice Margareth de Almeida Rodolpho | Molecular Neuroscience | Best Researcher Award

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Mrs. Joice Margareth de Almeida Rodolpho | Molecular Neuroscience | Best Researcher Award

Mrs. Joice Margareth de Almeida Rodolpho, Universidade Federal de São Carlos, Brazil.

Joice Margareth de Almeida Rodolpho is a dedicated Brazilian researcher with a strong foundation in biotechnology, parasitology, immunology, and molecular biology. She earned her Master’s and Ph.D. from the Federal University of São Carlos (UFSCar), where she explored the role of eosinophils as antigen-presenting cells in parasitic infections like Toxocara canis and Schistosoma mansoni. Her work is recognized for integrating experimental immunology with therapeutic innovations, such as the evaluation of natural plant extracts and nanomaterials for infection control. She further specialized in Flow Cytometry and Oncohematology, enhancing her analytical capabilities. With multiple awards and citations, her impactful contributions continue to strengthen Brazil’s standing in parasitological and immunological research.

Profile

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🎓 Early Academic Pursuits

Joice Margareth de Almeida Rodolpho began her academic journey in Brazil, developing a strong foundation in the life sciences. Her early interest in molecular biology and parasitology led her to pursue advanced studies at the esteemed Universidade Federal de São Carlos (UFSCar). She earned her Master’s degree in Biotechnology between 2009 and 2012, conducting significant research on Toxocara canis, particularly on the phenotypic characterization of eosinophils as antigen-presenting cells. This early work not only revealed her meticulous scientific inquiry but also laid the groundwork for her deeper exploration into immunology.

🧬 Professional Endeavors in Molecular and Evolutionary Genetics

Driven by a passion for understanding immune responses, Joice pursued a Ph.D. in Evolutionary Genetics and Molecular Biology at UFSCar from 2013 to 2017. Her doctoral research focused on the role of eosinophils as antigen-presenting cells both in vitro and ex vivo, offering vital insights into host-parasite interactions and immune regulation. Her work during this period was supported by a prestigious FAPESP scholarship, demonstrating her academic excellence and the relevance of her contributions. Under the mentorship of Professor Fernanda de Freitas Anibal, Joice refined her skills in experimental immunology and cellular biology.

🧪 Contributions and Research Focus in Parasitology and Immunopathology

Joice Rodolpho’s primary research interests lie at the intersection of parasitology, cellular immunology, and experimental pathology. Her studies explore how parasitic infections, such as those caused by Schistosoma mansoni and Toxocara canis, affect immune cell function, especially eosinophils. She has also contributed to investigations into natural plant extracts, like Mentha piperita L., assessing their therapeutic potential in modulating parasitic infections. Moreover, she extended her expertise to the field of nanomaterials, evaluating the cytotoxicity and cell death mechanisms induced by compounds like Ag₂WO₄, thus bridging classical parasitology with emerging biomedical technologies.

🏅 Accolades and Recognition in Scientific Circles

Throughout her career, Joice has received several recognitions that reflect the impact and originality of her research. In 2010, she was honored with a Menção Honrosa (Honorable Mention) for her work on Mentha piperita L. in treating Schistosoma mansoni, earning 2nd place in diagnostics and treatment. She continued to gain academic acclaim with awards at major conferences, including the VI Congresso da Sociedade Paulista de Parasitologia (2012) and the XXII B-MRS Meeting in 2024, highlighting her work on cytotoxic responses and innovative parasitological control methods. In 2024, her project on the parasitological and pathological evaluation of AW-HRL-C for schistosomiasis control was notably recognized by UNIFESP.

🧠 Impact and Influence in Experimental Immunology

Joice’s dedication to experimental immunology and cytometry has allowed her to mentor and influence upcoming researchers, especially in specialized fields such as flow cytometry. Her recent specialization in Immunology and Oncohematology by Flow Cytometry (2021–2022) at IPESSP further enriched her profile, showcasing her commitment to continuous learning and application of advanced technologies in immune profiling. Her ability to merge classical immunopathology with state-of-the-art cytometric tools reflects her versatility and forward-thinking scientific approach.

🌱 Legacy and Future Contributions in Biomedical Science

Poised to make lasting contributions, Joice Margareth de Almeida Rodolpho stands at the forefront of research into host-pathogen interactions, parasitic disease management, and immune cell function modulation. Her unique interdisciplinary approach—integrating molecular biology, natural product pharmacology, and immunological techniques—positions her as a valuable contributor to both academic research and potential therapeutic advancements. She is expected to lead innovative research in the treatment of neglected tropical diseases and immunological disorders, with implications for global health.

🔬 Research Field Relevance and Scientific Identity

As a scholar deeply embedded in the Brazilian scientific ecosystem, Joice’s identity is reflected in her multiple citation forms, indicating her widespread academic collaborations and international visibility. Her expertise bridges evolutionary genetics, biotechnology, cytometry, and immunoparasitology—making her a multifaceted researcher. Her contributions are cited under various names such as “RODOLPHO, JOICE M. A.” and “Joice Margareth de Almeida Rodolpho,” reflecting a robust presence in scholarly literature and ensuring her work continues to guide parasitological and immunological research for years to come.

Publication

  • Title: Biomarkers and Mental Disorders: A Relevance Analysis Using a Random Forest Algorithm
    Authors: Joice M. A. Rodolpho; Krissia F. Godoy; Bruna D. L. Fragelli; Jaqueline Bianchi; et al.
    Year: 2025

 

  • Title: Death Risk Score Model of Hospitalized COVID‐19 Patients: A Cohort Study
    Authors: Gustavo A. Cruz; Thais B. Boteon; Henrique Pott; Joice M. A. Rodolpho; et al.
    Year: 2025

 

  • Title: Synergistic Antifungal Effect and In Vivo Toxicity of a Monoterpene Isoespintanol Obtained from Oxandra xylopioides Diels
    Authors: Orfa I. C. Martínez; Alberto Angulo; Joice Rodolpho; Krissia F. Godoy; et al.
    Year: 2024

 

  • Title: Synergistic Antifungal Effect and In Vivo Toxicity of the Monoterpene Isoespintanol Obtained from Oxandra xylopioides Diels (Preprint)
    Authors: Orfa I. C. Martínez; Alberto Angulo; Joice M. A. Rodolpho; et al.
    Year: 2024

 

  • Title: Carbon Black CB-EDA Nanoparticles in Macrophages: Changes in the Oxidative Stress Pathway and in Apoptosis Signaling
    Authors: Joice M. A. Rodolpho; Krissia F. Godoy; Bruna D. L. Fragelli; et al.
    Year: 2023

 

  • Title: HGPRT and PNP: Recombinant Enzymes from Schistosoma mansoni and Their Role in Immunotherapy during Experimental Murine Schistosomiasis
    Authors: Bruna D. L. Fragelli; Ana C. Fattori; Joice M. A. Rodolpho; et al.
    Year: 2023

 

  • Title: Titanium Dioxide Nanoparticle (TiO2 NP) Induces Toxic Effects on LA-9 Mouse Fibroblast Cell Line
    Authors: Ana C. M. Fattori; Patricia Brassolatti; Joice M. A. Rodolpho; et al.
    Year: 2023

 

  • Title: Analysis of Cytotoxicity and Genotoxicity in a Short-Term Dependent Manner Induced by a New Titanium Dioxide Nanoparticle in Murine Fibroblast Cells
    Authors: Pedrino, M.; Brassolatti, P.; Joice M. A. Rodolpho; et al.
    Year: 2022

 

  • Title: Functionalized Titanium Nanoparticles Induce Oxidative Stress and Cell Death in Human Skin Cells
    Authors: Brassolatti, P.; Joice M. A. Rodolpho; Krissia F. Godoy; et al.
    Year: 2022

 

  • Title: Toxicological Effects of the Mixed Iron Oxide Nanoparticle (Fe₃O₄ NP) on Murine Fibroblasts LA-9
    Authors: Alves Feitosa, K.; Joice M. A. Rodolpho; et al.
    Year: 2022

 

🧾 Conclusion

Joice Rodolpho’s academic journey and scientific contributions reveal a researcher of high caliber, committed to advancing our understanding of host-pathogen dynamics and immune system function. Her work, grounded in rigorous experimentation and innovation, holds promise for developing novel therapies for neglected tropical diseases. With a forward-looking approach and interdisciplinary expertise, she stands out as a key contributor in biomedical science, poised to influence future discoveries in immunopathology and disease control.