Che Ping Cheng | Translational Neuroscience | Best Researcher Award

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Prof. Che Ping Cheng | Translational Neuroscience | Best Researcher Award

Prof. Che Ping Cheng, Wake Forest University School of Medicine, United States.

Dr. Che Ping Cheng, M.D., Ph.D., FAHA, is a distinguished cardiovascular physiologist and internal medicine specialist whose career has been dedicated to advancing the understanding of heart function and failure. From earning his medical degree in China to completing a Ph.D. in Physiology at Wayne State University, and later conducting pivotal postdoctoral research at Wake Forest School of Medicine, Dr. Cheng has consistently pursued excellence in science and education. His research on ventricular mechanics, volume loading, and heart failure has significantly influenced both experimental cardiology and clinical practice. Recognized as a Fellow of the American Heart Association, he is also a dedicated mentor, shaping the next generation of cardiovascular researchers through his academic leadership.

Profile

Scopus

 

šŸŽ“ Early Academic Pursuits

Dr. Che Ping Chengā€™s journey into medicine and science began in Nanjing, China, where he earned his M.D. degree from Nanjing Railway Medical University in 1977. His early academic path reflected a deep interest in understanding the intricacies of human health, particularly in cardiovascular physiology. Driven by a desire to expand his knowledge and research capabilities, Dr. Cheng pursued his Ph.D. in Physiology at Wayne State University School of Medicine in Detroit, Michigan, completing his degree in 1986. Under the mentorship of Dr. Robert S. Shepard, his doctoral work focused on exploring the mechanisms of cardiovascular response to volume loading in a canine model with tricuspid valvulectomy, setting a strong foundation for his lifelong focus on heart function and disease mechanisms.

šŸ©ŗ Professional Endeavors

Following his academic training, Dr. Cheng embarked on postdoctoral studies at the Bowman Gray School of Medicine (now part of Wake Forest School of Medicine), where he continued to cultivate his expertise in internal medicine and cardiovascular physiology. Between 1986 and 1988, he served as a Postdoctoral Fellow under the guidance of Dr. William C. Little. His research during this period focused on ventricular dynamics and the physiological factors affecting active ventricular filling, which would later inform his broader work on heart failure and cardiac function. Dr. Cheng has since remained at Wake Forest School of Medicine, where he is currently a distinguished member of the Section on Cardiovascular Medicine.

šŸ§Ŗ Contributions and Research Focus

Dr. Cheng’s career has been characterized by a deep commitment to advancing the understanding of cardiac hemodynamics, ventricular interaction, and heart failure mechanisms. His research has explored how ventricular function responds under altered physiological states, and how these responses inform disease progression and treatment strategies. His early animal model studies have provided critical insights into the interplay between structural and functional changes in the heart, especially in the context of diastolic dysfunction and volume overload conditions. Dr. Cheng has also made significant strides in translating these findings to clinical contexts, influencing how cardiologists approach diagnosis and therapy.

šŸ… Accolades and Recognition

Throughout his career, Dr. Cheng has received considerable recognition for his scholarly contributions. He is a Fellow of the American Heart Association (FAHA), an honor that reflects his standing in the field of cardiovascular research and his commitment to scientific excellence. His work has earned the respect of colleagues and institutions alike, leading to numerous invitations to contribute to collaborative projects, serve on peer-review panels, and mentor future generations of cardiovascular researchers.

šŸŒ Impact and Influence

Dr. Cheng’s work has had a lasting impact on both experimental and clinical cardiology. By elucidating the mechanistic basis of ventricular dysfunction, he has helped shift paradigms in heart failure management, particularly in the areas of ventricular interdependence and preload responsiveness. His research findings are frequently cited in textbooks and high-impact journals, and they continue to inform guidelines for cardiac care and interventions. Through his work at Wake Forest and beyond, Dr. Cheng has played a pivotal role in bridging laboratory discoveries with bedside applications.

šŸ‘Øā€šŸ« Legacy and Mentorship

As a respected mentor and educator, Dr. Cheng has dedicated a significant portion of his career to training medical students, residents, and postdoctoral fellows. His mentorship has influenced numerous emerging scholars in cardiovascular medicine, many of whom have gone on to successful academic and clinical careers. His guidance combines a rigorous scientific approach with a deep sense of responsibility to patient care and scientific integrity, shaping a legacy that extends well beyond his own research output.

šŸ”¬ Future Contributions and Vision

Looking ahead, Dr. Cheng remains committed to the advancement of cardiovascular research, with a continued focus on uncovering the cellular and mechanical determinants of heart disease. His vision includes fostering collaborative projects that integrate biomedical engineering, imaging, and computational modeling to further understand cardiac performance. With decades of experience and a forward-thinking approach, Dr. Chengā€™s future contributions are poised to leave a lasting mark on the field of translational cardiovascular medicine.

Publication

  1. Title: Increased CaMKII activation and contrast changes of cardiac Ī²1-and Ī²3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension
    Authors: Sun, Xiaoqiang; Cao, Jing; Chen, Zhe; Ferrario, Carlos M.; Cheng, Cheping
    Year: 2023
    Journal: Heliyon

 

  1. Title: Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice
    Authors: Mikhailov, Alexei V.; Liu, Yixi; Cheng, Hengjie; Lin, Jen Jar; Cheng, Cheping
    Year: 2022
    Journal: Heliyon

 

  1. Title: Chronic GPR30 agonist therapy causes restoration of normal cardiac functional performance in a male mouse model of progressive heart failure: Insights into cellular mechanisms
    Authors: Zhang, Xiaowei; Li, Tiankai; Cheng, Hengjie; Groban, Leanne; Cheng, Cheping
    Year: 2021
    Journal: Life Sciences

 

  1. Title: Chronic Ca2+/calmodulin-dependent protein Kinase II inhibition rescues advanced heart failure
    Authors: Liu, Yixi; Shao, Qun; Cheng, Hengjie; Zhao, David Xiao Ming; Cheng, Cheping
    Year: 2021
    Journal: Journal of Pharmacology and Experimental Therapeutics

 

  1. Title: The Angiotensin-(1ā€“12)/Chymase axis as an alternate component of the tissue renin angiotensin system
    Authors: Ferrario, Carlos M.; Groban, Leanne; Wang, Hao; Sun, Xuming; Ahmad, Sarfaraz
    Year: 2021
    Journal: Molecular and Cellular Endocrinology

 

  1. Title: Reversal of angiotensin-(1ā€“12)-caused positive modulation on left ventricular contractile performance in heart failure: Assessment by pressure-volume analysis
    Authors: Li, Tiankai; Zhang, Zhi; Zhang, Xiaowei; Ferrario, Carlos M.; Cheng, Cheping
    Year: 2020
    Journal: International Journal of Cardiology

 

  1. Title: Female Heart Health: Is GPER the Missing Link?
    Authors: Groban, Leanne; Tran, Q. K.; Ferrario, Carlos M.; Wang, Hao; Lindsey, Sarah H.
    Year: (Not specified, but likely 2020 or 2021)
    Journal: (Not specified)

 

šŸ Conclusion

Dr. Cheng’s legacy is one of intellectual rigor, clinical relevance, and mentorship. His work has not only deepened the scientific understanding of cardiac physiology but has also shaped modern approaches to diagnosing and managing heart failure. With a career spanning continents and disciplines, Dr. Cheng continues to be a guiding force in cardiovascular medicine, and his future contributions are anticipated to further advance the frontiers of heart research and patient care.

 

Camilla Bellone | Translational Neuroscience | Best Researcher Award

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Assoc. Prof. Dr. Camilla Bellone | Translational Neuroscience | Best Researcher Award

Assoc. Prof. Dr. Camilla Bellone,Ā  University of Geneva, Switzerland.

Dr. Camilla Bellone is a renowned neuroscientist whose academic and research career has been marked by excellence, innovation, and impact. From her foundational training in Italy to her leadership role in Geneva, she has made pioneering contributions to understanding the neural underpinnings of social behavior. Her work bridges basic science and clinical relevance, and she has played a vital role in training, mentorship, and international collaboration within the neuroscience community.

Profile

Google Scholar

 

šŸŽ“ Early Academic Pursuits

Dr. Camilla Bellone began her academic journey with a Masterā€™s degree in Pharmacy from the University of Milano in 2000. With a strong foundation in pharmacology and medical chemistry, she pursued her Ph.D. in ā€œPharmacology, Toxicology, and Medical Chemotherapyā€ at the same institution, completing it in 2006. Her early education shaped a robust scientific mindset, preparing her for a career at the intersection of neuroscience and pharmacology. These formative years set the tone for her later work on the molecular mechanisms that govern complex behaviors in both healthy and diseased states.

šŸ§Ŗ Professional Endeavors

After her doctoral studies, Dr. Bellone enhanced her research acumen through a postdoctoral fellowship at the University of California, San Francisco (UCSF), gaining international exposure. She later returned to Switzerland, where she served as a scientist under the Ambizione Fellowship at the University of Geneva. Her academic path took a significant leap when she became an Assistant Professor at the University of Lausanne in 2014, followed by a transition to the University of Geneva in 2016. In 2020, she was promoted to Associate Professor in the Department of Basic Neuroscience, where she continues to lead cutting-edge investigations and mentor future neuroscientists.

šŸ§  Contributions and Research Focus

At the core of Dr. Belloneā€™s research lies a deep interest in the neurobiological basis of social behavior, with a particular focus on how these processes are disrupted in neuropsychiatric disorders. Her lab explores the synaptic and circuit-level mechanisms that underpin social cognition, often using advanced molecular and behavioral techniques. Her work has provided critical insights into how alterations in neural plasticity and connectivity contribute to diseases such as schizophrenia and autism spectrum disorders. With over 40 peer-reviewed publications in high-impact journals like Nature Neuroscience and Neuron, Dr. Bellone’s research continues to advance the field of behavioral neuroscience.

šŸ† Accolades and Recognition

Dr. Belloneā€™s scientific excellence has been recognized through several prestigious honors. In 2023, she received the EBBS Mid-Career Award and the Leenaards Scientific Prize for her collaborative project on cerebellar stimulation in schizophrenia. Earlier, she was elected to the distinguished FENS-KAVLI Network of Excellence in 2015, highlighting her position among Europe’s most promising neuroscientists. In 2014, she was honored with the Fondation du Prix Pfizer de la Recherche, marking an early milestone in her independent research career.

šŸŒ Impact and Influence

Beyond her lab, Dr. Bellone has made meaningful contributions to the academic and scientific community. She has delivered over 20 invited lectures at international conferences and institutions, sharing her discoveries with a global audience. As a dedicated mentor, she has guided eight masterā€™s students and seven PhD candidates, nurturing the next generation of neuroscientists. Her commitment extends to active service on academic committees, grant review panels, and editorial boards, reflecting her role as a respected leader in the field.

šŸ‘©ā€šŸ”¬ Balancing Science and Life

A champion of work-life integration, Dr. Bellone has managed to thrive professionally while embracing motherhood. She took two career breaks following the birth of her three children, exemplifying resilience and balance in a demanding academic landscape. Her story is an inspiration to young scientists, especially women, striving to build careers in STEM while honoring personal life choices.

šŸ”¬ Legacy and Future Contributions

Looking ahead, Dr. Belloneā€™s work holds promise for transforming our understanding of social dysfunction in mental illness. Her innovative approachesā€”blending circuit neuroscience, pharmacology, and behaviorā€”position her as a leading voice in the neurobiology of social behavior. With continued support from initiatives like the ERC Consolidator Grant, her research will likely pave the way for novel therapeutic interventions, leaving a lasting legacy in neuroscience and psychiatry.

Publication

  • Title: NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
    Author: P Paoletti, C Bellone, Q Zhou
    Year: 2013

 

  • Title: Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression
    Author: C Bellone, C LĆ¼scher
    Year: 2006

 

  • Title: Rapid bidirectional switching of synaptic NMDA receptors
    Author: C Bellone, RA Nicoll
    Year: 2007

 

  • Title: Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area
    Author: M Mameli, C Bellone, MTC Brown, C LĆ¼scher
    Year: 2011

 

  • Title: In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons
    Author: A De la Rossa, C Bellone, B Golding, I Vitali, J Moss, N Toni, C LĆ¼scher, …
    Year: 2013

 

  • Title: Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
    Author: C Bellone, C LĆ¼scher, M Mameli
    Year: 2008

 

  • Title: Effects of streptozotocinā€diabetes on the hippocampal NMDA receptor complex in rats
    Author: F Gardoni, A Kamal, C Bellone, GJ Biessels, GMJ Ramakers, F Cattabeni, …
    Year: 2002

 

  • Title: Neurons under T cell attack coordinate phagocyte-mediated synaptic stripping
    Author: G Di Liberto, S Pantelyushin, M Kreutzfeldt, N Page, S Musardo, R Coras, …
    Year: 2018

 

  • Title: mGluRs induce a longā€term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors
    Author: C Bellone, C LĆ¼scher
    Year: 2005

 

  • Title: SHANK3 controls maturation of social reward circuits in the VTA
    Author: S Bariselli, S Tzanoulinou, C Glangetas, C PrĆ©vost-SoliĆ©, L Pucci, …
    Year: 2016

 

āœ… Conclusion

Dr. Belloneā€™s journey reflects a remarkable blend of scientific curiosity, academic leadership, and personal resilience. As she continues to explore the brain’s most intricate social circuits, her influence will undoubtedly expand across neuroscience, psychiatry, and therapeutic innovation. Her career serves as both a roadmap and an inspiration for emerging scientists navigating the evolving landscape of brain research.