Gulcin Gacar | Neurodegenerative Disease | Best Researcher Award

Assoc. Prof. Dr. Gulcin Gacar | Neurodegenerative Disease | Best Researcher Award

Prof. Dr. Gulcin Gacar | Kocaeli University | Turkey

Associate Professor Dr. Gulcin Gacar of Kocaeli University is a distinguished researcher and educator in the fields of stem cell biology, regenerative medicine, and clinical microbiology. With over 200 scientific publications, including 54 in Web of Science and 37 in Scopus, she has garnered more than 900 citations and achieved an h-index of 17. Her groundbreaking research focuses on mesenchymal stem cells and exosomes, particularly their applications in neurodegenerative diseases like Alzheimer’s. She leads nationally funded projects and serves as a mentor to graduate students, contributing significantly to Turkey’s scientific advancement in cellular and molecular therapy.

Academic Profile

Google Scholar
Orcid

Early Academic Pursuits

From the outset of her academic journey, Dr. Gülçin Gacar exhibited a strong dedication to medical sciences, particularly clinical microbiology and regenerative medicine. Her foundational studies laid the groundwork for her specialization in stem cell biology and advanced biomedical techniques. As she advanced through the academic ranks, her commitment to translational research became evident, inspiring a deep dive into the dynamic world of mesenchymal stem cells and cellular therapies.

Professional Endeavors

Currently serving as an Associate Professor at Kocaeli University, Dr. Gacar is affiliated with the Center for Stem Cell and Gene Therapies under the Institute of Health Sciences. She plays a critical role in bridging theoretical knowledge with clinical application. Her professional journey is characterized by a robust combination of teaching, research, and leadership, where she supervises graduate-level research and oversees important institutional initiatives in stem cell-based innovation.

Contributions and Research Focus

Dr. Gacar’s research primarily revolves around mesenchymal stem cells, exosomes (extracellular vesicles), and advanced applications of stem cell biology. One of her key projects involves investigating the therapeutic potential of exosomes derived from adipose tissue-origin mesenchymal stem cells on Alzheimer’s disease models using human neuroblastoma SHSY5Y cells. This cutting-edge study, supported by national scientific funding, illustrates her focus on neurological disorders and cellular therapies. With over 200 academic publications, including 54 indexed in Web of Science and 37 in Scopus, her work has become a cornerstone in regenerative medicine and neurocellular research.

Accolades and Recognition

Dr. Gacar’s exceptional scholarship is reflected in her impressive citation record—garnering over 900 citations with an h-index of 16 on Web of Science and 17 on Scopus. These metrics not only underscore the academic relevance of her research but also highlight her influence in the global scientific community. Her contributions have positioned her as a key opinion leader and trusted consultant in TÜBİTAK-funded national projects, further validating her expertise and dedication to scientific excellence.

Impact and Influence

Beyond publications and projects, Dr. Gacar is actively involved in mentoring the next generation of scientists. She has supervised numerous graduate theses, fostering a research culture grounded in innovation, rigor, and ethical science. Her influence extends into policy-making and practical clinical research, making her a vital figure in the implementation of stem cell technologies in both experimental and therapeutic contexts.

Legacy and Future Contributions

Dr. Gacar continues to expand the frontiers of stem cell research and regenerative neuroscience. Her ongoing efforts in developing novel diagnostic and therapeutic modalities through cellular and molecular engineering are poised to transform clinical approaches to degenerative diseases. With each project and publication, she reinforces her commitment to scientific discovery and paves the way for future breakthroughs in biotechnology and personalized medicine.

Neuroscience and Regenerative Innovation

At the intersection of neuroscience and regenerative biology, Dr. Gacar’s work exemplifies the possibilities of interdisciplinary research. Her current focus on exosome-based therapies in neurodegenerative conditions represents a bold step into the future of non-invasive, cell-free therapeutics. As the landscape of neuroscience evolves, her pioneering work will undoubtedly contribute to novel clinical strategies and global scientific advancement.

Publication

Isolation and in vitro characterisation of dental pulp stem cells from natal teeth
E Karaöz, BN Doğan, A Aksoy, G Gacar, S Akyüz, S Ayhan, ZS Genç
2010

Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers
E Karaoz, A Aksoy, S Ayhan, AE Sarıboyacı, F Kaymaz, M Kasap
2009

Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum
K Schallmoser, E Rohde, A Reinisch, C Bartmann, D Thaler, C Drexler, …
2008

High prevalence of OXA-51-type class D β-lactamases among ceftazidime-resistant clinical isolates of Acinetobacter spp.: co-existence with OXA-58 in multiple …
H Vahaboglu, F Budak, M Kasap, G Gacar, S Torol, A Karadenizli, …
2006

Immunoregulatory effects of human dental pulp-derived stem cells on T cells: comparison of transwell co-culture and mixed lymphocyte reaction systems
PC Demircan, AE Sariboyaci, ZS Unal, G Gacar, C Subasi, E Karaoz
2011

Protective effects of resveratrol on aging-induced cognitive impairment in rats
SS Gocmez, N Gacar, T Utkan, G Gacar, PJ Scarpace, N Tumer
2016

The paracrine immunomodulatory interactions between the human dental pulp derived mesenchymal stem cells and CD4 T cell subsets
AT Özdemir, RBÖ Özdemir, C Kırmaz, AE Sarıboyacı, ZSÜ Halbutoğlları, …
2016

PER-1 is still widespread in Turkish hospitals among Pseudomonas aeruginosa and Acinetobacter spp.
F Kolayli, G Gacar, A Karadenizli, A Sanic, H Vahaboglu, Study Group
2005

Phenotypic and proteomic characteristics of human dental pulp derived mesenchymal stem cells from a natal, an exfoliated deciduous, and an impacted third molar tooth
G Akpinar, M Kasap, A Aksoy, G Duruksu, G Gacar, E Karaoz
2014

The role of PIN1 on odontogenic and adipogenic differentiation in human dental pulp stem cells
YM Lee, SY Shin, SS Jue, IK Kwon, EH Cho, ES Cho, SH Park, EC Kim
2014

Conclusion 

Considering her scholarly output, impactful research on stem cell-based therapies, leadership in national research initiatives, and dedication to mentoring, Dr. Gulcin Gacar is highly deserving of the Best Researcher Award. Her innovative work in exosome-based treatment strategies for neurodegenerative diseases positions her as a leader in translational medical science. With continued emphasis on global engagement and high-impact dissemination, her research will not only advance scientific frontiers but also contribute meaningfully to patient care and public health. Thus, she stands as an exemplary model of academic excellence, innovation, and social relevance in biomedical sciences.

Rosario Osta | Molecular and Cellular Neuroscience | Best Researcher Award

Prof.Dr. Rosario Osta | Molecular and Cellular Neuroscience | Best Researcher Award

Prof. Dr. Rosario Osta, CIBERNED-Fundación Instituto de Investigación Sanitaria de Aragón-Universidad de Zaragoza,  Spain.

Prof. Rosario Osta Pinzolas is a distinguished geneticist and full professor at the University of Zaragoza, Spain. Her academic roots in veterinary sciences and a Ph.D. in Genetics laid the foundation for a prolific career in biomedical research, particularly in the fields of neuroscience and genetic disorders. With leadership roles in multiple high-profile research consortia such as CIBERNED, TRICALS, and ENCALS, she has established herself as a central figure in neurodegenerative disease research. Her scholarly output includes over 100 indexed publications, multiple national and international research projects, and an h-index exceeding 45.

Profile

Orcid 

Scopus

 

🎓 Early Academic Pursuits

Rosario Osta Pinzolas began her academic journey with a solid foundation in veterinary sciences, graduating as Licenciada en Veterinaria from the University of Zaragoza in 1989. Her academic inclinations quickly shifted toward molecular genetics, leading her to complete a Ph.D. in Genetics at the same university in 1994. Her early studies were driven by a deep curiosity about the mechanisms of heredity and gene expression, setting the tone for a lifelong commitment to biomedical research. These formative years cultivated her scientific rigor and sowed the seeds for a career that would eventually bridge basic science and translational medicine.

🧬 Professional Endeavors in Genetics and Biomedicine

Prof. Osta currently holds the esteemed title of Catedrática (Full Professor) in the Department of Anatomy, Embryology, and Genetics at the Faculty of Veterinary Medicine, University of Zaragoza. Since 2018, she has led her department with a focus on integrative biomedical sciences. She is the principal investigator of the LAGENBIO group recognized by both the Aragon Health Research Institute and the Government of Aragon. Under her leadership, the group has developed two major subprograms: TERAGEN and REGENERAGEN. As coordinator of the “Neuroscience and Mental Health Program” at IISA, she has spearheaded numerous efforts to understand and address neurological diseases through genetic approaches.

🧠 Contributions and Research Focus in Neuroscience

A prominent figure in neuroscience, Prof. Osta’s research lies at the intersection of genetics and neurodegeneration. She is currently the principal investigator of the only Aragon-based group within CIBERNED (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas), reflecting her national influence. Her team represents Zaragoza in prominent European consortia such as TRICALS and ENCALS, both focused on amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. Through more than 100 indexed publications, predominantly in top-tier journals, her work delves into the molecular underpinnings of neurological disorders and explores regenerative medicine strategies, thereby contributing to innovative therapeutic avenues.

🧪 Accolades and Recognition in Scientific Excellence

Prof. Osta’s academic and research career has been punctuated by consistent recognition. She has completed five research productivity periods and one technology transfer period, acknowledged by CNEAI — a mark of sustained scientific impact. She has led over 74 research projects and contributed to more than 100 collaboration contracts, earning her four competitive research awards from respected institutions including CORIS, AREA, IIS, and SEBBM. Her contributions have been lauded not only for scientific quality but also for practical relevance in biomedical advancements.

🚀 Innovation and Impact in Translational Research

An ardent advocate for science with societal impact, Prof. Osta has significantly contributed to technology transfer. She holds nine patents, five of which have been licensed to industry partners. Her collaborations with companies have led to meaningful translational outputs, emphasizing her role in bridging the gap between academic research and real-world solutions. As former Director of the Technology Transfer and Innovation Secretariat at the University of Zaragoza for nearly a decade, she played a crucial role in institutional innovation strategies. Her involvement in joint university-company chairs and her role in the UZ Technology-Based Business Creation Committee for over 12 years further underscore her influence on academic entrepreneurship.

📚 Mentorship and Educational Leadership

Beyond the lab, Prof. Osta has left a profound mark as an educator and mentor. Since 2013, she has coordinated the Interuniversity Doctoral Program in Biomedical and Biotechnological Sciences, a joint initiative between the Universities of Zaragoza and La Rioja. Her mentorship includes the supervision of 13 Ph.D. theses — 9 of which earned international distinction and 6 received extraordinary doctoral awards. Her influence extends to guiding numerous undergraduate and master’s theses, fostering a new generation of scientists with a deep commitment to research excellence and innovation.

🌍 Legacy and Future Contributions

Prof. Rosario Osta’s legacy is defined by her ability to integrate scientific discovery, mentorship, and innovation. As a member of the Scientific Committee of the Luzón Foundation, her vision reaches beyond academia into public health advocacy and strategic research planning. With nearly 19,000 citations on Google Scholar and an h-index of 45, her work continues to inspire and inform global research communities. Her continued leadership in collaborative European projects ensures her contributions will shape the future of neuroscience, genetics, and translational medicine for years to come.

Publication

Title: Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice
Authors: L. Moreno-Martinez, N. Gaja-Capdevila, L. Mosqueira-Martín, R. Osta, F.J. Gil-Bea
Year: 2025

Title: Identifying Hub Genes and miRNAs Associated with Alzheimer’s Disease: A Bioinformatics Pathway to Novel Therapeutic Strategies
Authors: E. Gascón, A.C. Calvo, N. Molina, P. Zaragoza, R. Osta
Year: 2024

Title: Comparative Blood Profiling Based on ATR-FTIR Spectroscopy and Chemometrics for Differential Diagnosis of Patients with Amyotrophic Lateral Sclerosis—Pilot Study
Authors: K. Tkachenko, J.M. González Sáiz, A.C. Calvo, R. Osta, C. Pizarro Millán
Year: 2024

Title: Sex differences on constitutive long non-coding RNA expression: Modulatory effect of estradiol and testosterone in muscle cells
Authors: T. López-Royo, L. Moreno-Martinez, L. Moreno-García, R. Manzano, R. Osta
Year: 2024

Title: Differentially expressed lncRNAs in SOD1 G93A mice skeletal muscle: H19, Myhas and Neat1 as potential biomarkers in amyotrophic lateral sclerosis
Authors: T. López-Royo, L. Moreno-Martinez, P. Zaragoza, R. Manzano, R. Osta
Year: 2024

Title: Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia
Authors: P. Aparicio, D. Navarrete-Villanueva, A. Gómez-Cabello, R. Osta, R. Manzano
Year: 2024

Title: Sporadic Amyotrophic Lateral Sclerosis Skeletal Muscle Transcriptome Analysis: A Comprehensive Examination of Differentially Expressed Genes
Authors: E. Gascón, P. Zaragoza, A.C. Calvo, R. Osta
Year: 2024

Title: Intermediate Repeat Expansion in the ATXN2 Gene as a Risk Factor in the ALS and FTD Spanish Population
Authors: D. Borrego-Hernández, J.F. Vázquez-Costa, R. Domínguez Rubio, M. Povedano, A. García-Redondo
Year: 2024

Title: New Insights into Endogenous Retrovirus-K Transcripts in Amyotrophic Lateral Sclerosis
Authors: L. Moreno-Martinez, S. Macías-Redondo, M.H.P. Strunk, R. Osta, J. Schoorlemmer
Year: 2024

Title: Analysis of Plasma-Derived Exosomal MicroRNAs as Potential Biomarkers for Canine Idiopathic Epilepsy
Authors: M. García-Gracia, L. Moreno-Martinez, A. Hernaiz, S. García-Belenguer, I. Martín-Burriel
Year: 2024

🏆 Conclusion

Based on her outstanding research contributions, innovation in translational science, mentorship record, and leadership within national and European research programs, Prof. Rosario Osta Pinzolas is an exceptionally strong candidate for the Best Researcher Award. Her profile reflects not only academic excellence but also societal impact and visionary leadership. While there is room for enhanced global outreach, her sustained achievements and contributions make her highly deserving of this prestigious recognition.