Matteo Palermo | Neuroanatomy | Best Researcher Award

Mr. Matteo Palermo | Neuroanatomy | Best Researcher Award 

Mr. Matteo Palermo, Policlinico A. gemelli, Italy.

Matteo Palermo is an emerging medical scholar from Italy currently pursuing his medical degree at the Catholic University of the Sacred Heart in Rome. With a dual high school diploma from Italy and the USA, he demonstrated academic brilliance early on, which has been consistently recognized through multiple national and institutional awards. His professional engagements span prestigious neurosurgical institutions, including the Mayo Clinic and the Carlo Besta Institute. Matteo has already authored multiple peer-reviewed research publications in top-tier neurological and neurosurgical journals, focusing on hydrocephalus, intracranial hypertension, glioma imaging, and spinal hypotension treatment. His work reflects a commitment to clinical excellence, research depth, and global collaboration.

Profile

Google Scholar

 

🎓 Early Academic Pursuits

Matteo Palermo’s academic journey began with a deep commitment to excellence from a young age. Born and raised in Gravina in Puglia, Italy, he demonstrated a strong affinity for science and mathematics during his formative years at Liceo Scientifico Giuseppe Tarantino, earning a high school diploma in 2021. Matteo expanded his educational exposure internationally by attending Edgar High School in Wisconsin, USA, in 2018–2019, where he obtained a U.S. high school diploma and participated in national-level mathematics competitions, securing 29th place out of 50 participants. His early achievements laid a robust foundation for his future in medicine, strengthened by recognition from the Italian Ministry of Education and supported by a €16,000 academic grant.

🏥 Professional Endeavors

Currently pursuing a degree in medicine at the Catholic University of the Sacred Heart in Rome (2021–2027), Matteo has actively immersed himself in professional experiences that transcend academic learning. His early exposure to clinical environments began with prestigious internships and observerships in neurosurgery at globally renowned institutions. In 2024, he joined the Mayo Clinic in Rochester under the mentorship of Dr. Giuseppe Lanzino. His long-term neurosurgical internship at the Carlo Besta Institute in Milan, led by Dr. Francesco Prada, further reinforced his dedication to neurological sciences. Matteo also trained under Dr. Alessandro Olivi at Gemelli Hospital in 2025, engaging directly with surgical innovation and patient care.

🧠 Contributions and Research Focus

Matteo’s passion for neurosurgery is reflected in his impressive contributions to academic research. He has co-authored several high-impact studies, often in collaboration with experts like Dr. Trevisi, Dr. Prada, and Dr. Sturiale. His work delves into intricate neurological conditions such as idiopathic normal pressure hydrocephalus and idiopathic intracranial hypertension, particularly in pregnancy—addressing both clinical and surgical dimensions. His research on advanced neuroimaging techniques, including superb microvascular ultrasound in gliomas, stands at the frontier of neuro-oncological diagnostics. His recent meta-analyses, including one on targeted versus nontargeted epidural blood patches for spontaneous intracranial hypotension, showcase a methodological precision and a deep commitment to evidence-based practice.

🏅 Accolades and Recognition

Throughout his academic journey, Matteo has received numerous honors that highlight his consistent excellence. He was awarded the Best Medical Student Award at the Catholic University of the Sacred Heart for three consecutive years (2023, 2024, and 2025), an acknowledgment of both academic prowess and professional dedication. His distinction as the Faculty Representative of the Medicine and Surgery degree course in 2025 demonstrates his leadership qualities and the trust vested in him by peers and faculty alike. Earlier accolades, such as the Italian Student Excellence Award by the Ministry of Education and Excellence Student Awards during high school, further underline a pattern of sustained high achievement.

🌐 Impact and Influence

Matteo’s work in neurosurgery has begun to make a visible impact not only through scholarly publications but also through his collaborative roles in high-profile research institutions. His systematic reviews and responses in respected journals like Neurosurgical Review, European Journal of Neurology, and Acta Neurochirurgica have contributed to shaping current conversations around neurointerventions and treatment strategies. As a global research intern and contributor, Matteo’s growing influence is expanding beyond national borders, signaling a future as a thought leader in neuroclinical research.

📚 Legacy and Future Contributions

Even at this early stage, Matteo Palermo is carving out a promising legacy in the field of neuroscience and neurosurgery. His clear focus on integrating research, clinical application, and surgical excellence positions him as a future pioneer in the treatment of complex neurological conditions. With a solid base in both European and American medical systems and mentorship under globally respected neurosurgeons, Matteo’s future contributions are likely to influence neurosurgical standards, patient outcomes, and cross-disciplinary innovations for years to come.

🌟 Vision for Medical Research

Driven by a mission to bridge gaps between clinical neurosurgery and translational neuroscience, Matteo’s research vision is both ambitious and impactful. His ongoing focus on refining diagnostic and therapeutic techniques—particularly through systematic analysis and technological innovation—reflects a strong alignment with the future of precision medicine. Whether advancing shunt technologies for hydrocephalus or exploring maternal-fetal outcomes in neurological conditions, his commitment to enhancing the quality of care and knowledge dissemination is at the heart of his scholarly identity.

Publication

  • Advancing treatment strategies for idiopathic normal pressure hydrocephalus: a systematic review on studies comparing ventricular and lumbo-peritoneal shunts
    M. Palermo, G. Trevisi, F. Signorelli, F. Doglietto, A. Albanese, A. Olivi, …
    2025

 

  • Targeted Versus NonTargeted Epidural Blood Patch for Spontaneous Intracranial Hypotension: A Systematic Review and Meta‐Analysis
    M. Palermo, C.L. Sturiale, S. D’Arrigo, G. Trevisi
    2025

 

  • Idiopathic Intracranial Hypertension in Pregnancy: A Systematic Review on Clinical Course, Treatments, Delivery and Maternal‐Fetal Outcome
    M. Palermo, G. Trevisi, S. D’Arrigo, C.L. Sturiale
    2025

 

🏁 Conclusion

Matteo Palermo exemplifies the qualities of a future leader in the field of neurosurgery and neuroscience research. His early achievements, international exposure, and advanced research contributions mark him as an exceptional talent in academic medicine. With a solid foundation, continual academic distinction, and a vision for translational impact, Matteo is poised to make lasting contributions to the medical and scientific community. His trajectory strongly supports his candidacy for recognition, including honors such as the Best Researcher Award.

Irena Roterman | Computational Neuroscience | Best Researcher Award

Prof. Dr. Irena Roterman | Computational Neuroscience | Best Researcher Award

Prof. Dr. Irena Roterman, Jagiellonian University Medical College, Poland.

Prof. Irena Roterman-Konieczna is a distinguished scientist whose academic roots in theoretical chemistry and biochemistry evolved into groundbreaking contributions in bioinformatics. With a Ph.D. and habilitation in biochemistry, and a postdoctoral fellowship at Cornell University, she developed a unique perspective on protein structure and folding. Her most notable innovation is the Fuzzy Oil Drop (FOD) model, which simulates protein folding by incorporating environmental effects using a 3D Gaussian function to map hydrophobicity distribution. This model has wide applicability—from understanding membrane proteins and amyloids to analyzing domain-swapping and receptor anchoring.

Profile

Scopus

 

🎓 Early Academic Pursuits

Irena Roterman-Konieczna began her academic journey in theoretical chemistry at the prestigious Jagiellonian University, graduating from the Faculty of Chemistry in 1974. Her early interest in molecular structure and the physicochemical underpinnings of biological systems laid a strong foundation for her interdisciplinary career. She deepened her scientific expertise by earning a Ph.D. in biochemistry in 1984 from Nicolaus Copernicus Medical Academy in Krakow, focusing on the structure of the recombinant IgG hinge region. Her postdoctoral studies at Cornell University from 1987 to 1989, under the mentorship of Harold A. Scheraga, further shaped her academic development. There, she explored force fields used in prominent computational programs like AMBER, CHARMM, and ECEPP, bridging theoretical modeling with biomolecular reality.

🧬 Professional Endeavors in Bioinformatics

Throughout her career, Prof. Roterman-Konieczna has been at the forefront of bioinformatics, dedicating herself to unraveling the mysteries of protein structure and amyloid formation. Following her habilitation in biochemistry at the Jagiellonian University Faculty of Biotechnology in 1994 and the conferment of her professorial degree in medical sciences in 2004, she continued to pioneer innovative methods in structural bioinformatics. Her hallmark contribution, the Fuzzy Oil Drop (FOD) model, revolutionized the understanding of protein folding. The model uniquely incorporates environmental influence into folding simulations by using a 3D Gaussian function to describe hydrophobicity distribution—proposing that hydrophobic residues form a central core while hydrophilic residues remain exposed. This paradigm introduced a more realistic, dynamic framework for simulating in silico protein folding.

🧪 Contributions and Research Focus

Prof. Roterman-Konieczna’s research has explored how proteins behave not only in aqueous environments but also within membranes and under the influence of external force fields. By modifying the Gaussian-based FOD model, she extended its applicability to membrane proteins, enabling quantification of their anchoring mechanisms and mobility. Her investigations into chaperonins and domain-swapping phenomena further illustrate the power of her model to decode complex folding and protein-protein interactions. She introduced a dual-variable simulation function—accounting for both internal forces (non-bonded interactions within the protein chain) and external forces (environmental effects)—to guide structural transformation toward energy minima. These ideas are foundational in modern computational biology, where realistic folding predictions are critical for understanding disease mechanisms and therapeutic targeting.

📘 Scholarly Publishing and Intellectual Outreach

A prolific author, Prof. Roterman-Konieczna has made significant contributions to scientific literature. She has authored several influential books, many published in Open Access to promote knowledge sharing. These works include “Protein Folding In Silico” (Elsevier), “Systems Biology – Functional Strategies of Living Organism” (Springer), and “From Globular Proteins to Amyloids” (Elsevier, 2020). Her books elegantly communicate complex bioinformatic strategies, such as ligand binding site identification, protein-protein interactions, and computer-aided diagnostics. Moreover, her editorial leadership from 2005 to 2020 as Chief Editor of the journal Bio-Algorithms and Med-Systems cemented her influence in shaping interdisciplinary dialogues at the intersection of medicine, biology, and computation.

🏆 Accolades and Recognition

Prof. Roterman-Konieczna’s work has earned international acclaim. Notably, she is listed among the Top 2% scientists worldwide by Stanford University and Elsevier—a testament to her influential research and academic reputation. With 149 publications indexed in PubMed, her impact on the bioinformatics community is both broad and profound. Over the course of her career, she has also served as a mentor to 14 doctoral students, many of whom continue to contribute to research and innovation across various fields of biomedicine.

🌐 Impact and Influence

Her research has advanced global understanding of how proteins fold, interact, and misfold—a process central to neurodegenerative diseases such as Alzheimer’s. The FOD model continues to provide a computational lens for studying amyloid formation and supramolecular assemblies. Her model is also pivotal in studying receptor anchoring in membranes and exploring domain-swapping mechanisms critical to protein complex formation. By integrating thermodynamic theory, statistical modeling, and structural biology, her work bridges theoretical research with biomedical applications, pushing the boundaries of in silico experimentation.

🧭 Legacy and Future Contributions

Prof. Irena Roterman-Konieczna’s legacy is rooted in her visionary approach to molecular biology, championing models that blend computational precision with biological realism. Her commitment to open access publishing and academic mentoring reflects a deep dedication to inclusive, sustainable scientific progress. As systems biology and personalized medicine continue to evolve, her models and insights will remain cornerstones for future explorations in disease modeling, drug design, and molecular diagnostics. Her career exemplifies how interdisciplinary thinking and computational ingenuity can transform the life sciences, leaving a legacy that will guide future generations of scientists.

Publication

  • Title: Aquaporins as Membrane Proteins: The Current Status
    Authors: I.K. Roterman (Irena K.), K. Stapor (Katarzyna), D. Dułak (Dawid), G. Szoniec (Grzegorz), L. Konieczny (Leszek)
    Year: 2025

 

  • Title: DisorderUnetLM: Validating ProteinUnet for efficient protein intrinsic disorder prediction
    Authors: K. Kotowski (Krzysztof), I.K. Roterman (Irena K.), K. Stapor (Katarzyna)
    Year: 2025

 

  • Title: Protein folding: Funnel model revised
    Authors: I.K. Roterman (Irena K.), M. Slupina (Mateusz), L. Konieczny (Leszek)
    Year: 2024

 

  • Title: Domain swapping: a mathematical model for quantitative assessment of structural effects
    Authors: I.K. Roterman (Irena K.), K. Stapor (Katarzyna), D. Dułak (Dawid), L. Konieczny (Leszek)
    Year: 2024

 

  • Title: Chameleon Sequences─Structural Effects in Proteins Characterized by Hydrophobicity Disorder
    Authors: I.K. Roterman (Irena K.), M. Slupina (Mateusz), K. Stapor (Katarzyna), K. Gądek (Krzysztof), P. Nowakowski (Piotr)
    Year: 2024

 

  • Title: Transmembrane proteins—Different anchoring systems
    Authors: I.K. Roterman (Irena K.), K. Stapor (Katarzyna), L. Konieczny (Leszek)
    Year: 2024

 

  • Title: External Force Field for Protein Folding in Chaperonins─Potential Application in In Silico Protein Folding
    Authors: I.K. Roterman (Irena K.), K. Stapor (Katarzyna), D. Dułak (Dawid), L. Konieczny (Leszek)
    Year: 2024

 

  • Title: Structural features of Prussian Blue-related iron complex FeT of activity to peroxidate unsaturated fatty acids
    Authors: M. Lasota (Małgorzata), G. Zemanek (Grzegorz), O. Barczyk-Woźnicka (Olga), L. Konieczny (Leszek), I.K. Roterman (Irena K.)
    Year: 2024

 

  • Title: Editorial: Structure and function of trans-membrane proteins
    Authors: I.K. Roterman (Irena K.), M.M. Brylinski (Michal Michal), F. Polticelli (Fabio), A.G. de Brevern (Alexandre G.)
    Year: 2024

 

  • Title: Model of the external force field for the protein folding process—the role of prefoldin
    Authors: I.K. Roterman (Irena K.), K. Stapor (Katarzyna), L. Konieczny (Leszek)
    Year: 2024

 

🧠 Conclusion

Prof. Roterman-Konieczna’s career stands as a testament to how deep scientific insight and computational innovation can revolutionize biological understanding. Her FOD model not only enriches the study of protein dynamics but also provides a versatile framework for medical and pharmaceutical applications. With a legacy built on rigorous research, educational outreach, and academic leadership, her influence will continue to guide future advances in molecular biology, bioinformatics, and biomedical science.