Kazuyuki Matsushita | Neurodevelopmental Processes | Research Excellence Award

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Prof. Dr. Kazuyuki Matsushita | Neurodevelopmental Processes | Research Excellence Award

Prof. Dr. Kazuyuki Matsushita | Chiba University Hospital | Japan

Kazuyuki Matsushita is a senior academic and clinical scientist at Chiba University, Japan, with extensive expertise in laboratory medicine and translational diagnostics. He is affiliated with the Department of Laboratory Medicine, which integrates advanced sections including clinical chemistry, hematology, clinical microbiology, medical physiology, blood collection services, and genetic testing, all operating under internationally recognized analytical standards to ensure accurate, reproducible, and rapid assessment of physiological and pathological conditions. His work emphasizes the critical role of laboratory medicine in improving diagnostic precision and patient care. The clinical microbiology laboratory under his academic environment has made substantial contributions to infection control and hospital-based disease management, while genetic testing activities are closely aligned with clinical genetics to support precision medicine. A central focus of his research is the identification and validation of novel biomarkers and clinically meaningful indicators that enhance diagnosis, prognosis, and therapeutic decision-making beyond routine laboratory practice. His scholarly impact is reflected in 196 peer-reviewed documents, an h-index of 33, and 3,702 citations across 3,205 citing documents, demonstrating sustained influence in laboratory medicine, clinical microbiology, and diagnostic innovation at both national and international levels.

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Featured Publications

Genetic Variation in Background Mucosa Across Different Grades of Chronic Esophagitis
– Journal of Gastroenterology and Hepatology Australia, 2025

Hendry Ramly | Clinical Neuroscience | Research Excellence Award

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Dr. Hendry Ramly | Clinical Neuroscience | Research Excellence Award

Fiona Stanley | Australia

Dr. Hendry Ramly is a clinician–researcher with advanced training in general medicine, cardiology, and intensive care medicine, and a focused academic interest in non-traumatic out-of-hospital cardiac arrest and post-resuscitation care. His research is directly informed by frontline clinical practice across acute medicine, ICU, and cardiology, where he manages critically ill patients following cardiac arrest. Dr. Ramly’s primary research examines cardiovascular management strategies after return of spontaneous circulation, with particular emphasis on haemodynamic stabilisation, coronary pathology, and the timing and utility of urgent coronary angiography. Neurological outcomes are included as standard clinical endpoints, while the central focus remains on cardiovascular determinants of survival and in-hospital mortality. He is lead author of a retrospective observational cohort study published in Heart, Lung and Circulation (2025), evaluating outcomes of non-traumatic out-of-hospital cardiac arrest at a tertiary centre. His additional audit work includes thoracic surgical outcomes, geriatric referral pathways, and procedural adequacy in respiratory medicine. Through clinically driven research and multidisciplinary collaboration, Dr. Ramly aims to refine evidence-based pathways that improve survival, decision-making, and quality of care for patients following cardiac arrest.


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Featured Publication

Rachna Garg | Cognitive Neuroscience | Excellence in Research Award

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Ms. Rachna Garg | Cognitive Neuroscience | Excellence in Research Award

Ms. Rachna Garg | Tecnia Institute of Advanced Studies under GGSIPU | India

Ms. Rachna Garg is an accomplished Assistant Professor and Psychologist at Tecnia Institute of Advanced Studies, Delhi, bringing over a decade of experience in teaching, research, and psychological training. She is pursuing a Ph.D. in Psychology from Amity University, Gwalior, with a research focus on elderly mental health, resilience, and mindfulness-based cognitive interventions. She holds dual MBAs in Human Resource Management and Marketing, an MA in Psychology, and a B.Com (Hons) from Delhi University, reflecting a strong interdisciplinary background. Her scholarly output includes multiple international publications, book chapters, and research papers indexed in SCOPUS, Web of Science, and UGC-CARE. She has authored four book chapters with ISBNs and completed two major research projects on elderly mental health, alongside an ongoing Ph.D. empirical study. Her contributions extend to extensive training programs for MCD, NDMC, DIET, and SCERT educators, where she has delivered modules on communication, conflict management, learning disabilities, and sexual literacy. She has served as Convener for a notable Faculty Development Program on Indian Knowledge Systems. With an h-index of 1, a total of 10 documents, and 5 citations across ResearchGate and Google Scholar, she continues to advance impactful psychological research. She also holds editorial and reviewer roles in multiple reputed journals.

Profiles: Scopus | Orcid

Featured Publications

Garg, R. (2025, October 9). Rewiring the aging mind: A randomized controlled trial on the transformative impact of mindfulness-based cognitive behavioural therapy on depression and anxiety. Journal of Ecophysiology and Occupational Health.

Garg, R. (2025, September 13). Group-based mindfulness-based cognitive behavioral intervention for enhancing resilience and preventing depression and anxiety in at-risk elderly: A randomized controlled trial. Journal of Rational-Emotive & Cognitive-Behavior Therapy.

Garg, R. (2025, July 2). Evaluating the impact of mindfulness practices on depression, anxiety, and stress in geriatric populations: A randomized control trial. The Learning Curve, (ISSN 2321-7057).

Garg, R., Awasthi, S., & Gupta, N. (2025, January 2). The role of a 10-week mindfulness-based cognitive behavioral therapy intervention in managing depression, anxiety, and stress among the elderly: A quasi-experimental study. Journal of Neonatal Surgery, 14(21s). https://doi.org/10.63682/jns.v14i21s.5344

Garg, R., Awasthi, S., & Gupta, N. (2024, November). Mindfulness meets aging: The transformative power of mindfulness and cognitive behavioral interventions for mental health in the golden years. Indian Journal of Psychology, (ISSN 0019-5553).

Hui Zhang | Clinical Neuroscience | Best Researcher Award

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Prof. Hui Zhang | Clinical Neuroscience | Best Researcher Award

Prof. Hui Zhang | Northwestern University | United States

Hui Zhang is a Professor in the Division of Biostatistics, Department of Preventive Medicine at Northwestern University Feinberg School of Medicine, where he also holds appointments at the Robert H. Lurie Comprehensive Cancer Center, the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, and the Center for Epidemiology and Population Health. he serves as Director of the Northwestern Brain Tumor SPORE Biostatistics and Bioinformatics Core and leads the Biostatistics and Data Management Core at the Mesulam Center. With a Ph.D. in Statistics from the University of Rochester, her academic foundation spans pharmacology, neurophysiology, and biology, reflecting her interdisciplinary expertise in biostatistics and biomedical research. His previous experience includes research roles at St. Jude Children’s Research Hospital, where she contributed significantly to clinical and statistical protocol development. Professor Zhang’s work focuses on statistical methodologies for cancer and neurological disease research, data integration, and bioinformatics applications. he is an active member of several professional societies, including the American Statistical Association and the International Chinese Statistical Association. A highly cited researcher, she has accumulated over 11,422 citations, an h-index of 43, and an i10-index of 100, demonstrating her substantial impact and leadership in the fields of biostatistics and medical data science.

Profile: Google Scholar

Featured Publications

Moss, A. J., Hall, W. J., Cannom, D. S., Klein, H., Brown, M. W., Daubert, J. P., et al. (2009). Cardiac-resynchronization therapy for the prevention of heart-failure events. New England Journal of Medicine, 361(14), 1329–1338.

Gunzler, D., Chen, T., Wu, P., & Zhang, H. (2013). Introduction to mediation analysis with structural equation modeling. Shanghai Archives of Psychiatry, 25(6), 390–394.

Wan, T., Jun, H. U., Pan, W. U., & Hua, H. E. (2015). Kappa coefficient: A popular measure of rater agreement. Shanghai Archives of Psychiatry, 27(1), 62–67.

Pu, J., Wang, S., Yin, Y., Zhang, G., Carter, R. A., Wang, J., Xu, G., Sun, H., Wang, M., et al. (2015). Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus. Proceedings of the National Academy of Sciences, 112(2), 548–553.

Guy, C. S., Vignali, K. M., Temirov, J., Bettini, M. L., Overacre, A. E., Smeltzer, M., et al. (2013). Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nature Immunology, 14(3), 262–270.

Shen, S., Chen, X., Cai, J., Yu, J., Gao, J., Hu, S., Zhai, X., Liang, C., Ju, X., Jiang, H., et al. (2020). Effect of dasatinib vs imatinib in the treatment of pediatric Philadelphia chromosome–positive acute lymphoblastic leukemia: A randomized clinical trial. JAMA Oncology, 6(3), 358–366.

Sonabend, A. M., Gould, A., Amidei, C., Ward, R., Schmidt, K. A., Zhang, D. Y., et al. (2023). Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: A phase 1 trial. The Lancet Oncology, 24(5), 509–522.

Kathrin Eichinger | Clinical Neuroscience | Outstanding Contribution Award

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Dr. Kathrin Eichinger | Clinical Neuroscience | Outstanding Contribution Award 

Dr. Kathrin Eichinger | Medizinische Universitat Wien | Austria

Dr. Med. Kathrin Eichinger is an Austrian physician specializing in Pediatrics and Pediatric Neurology, currently serving as a Consultant in Child and Adolescent Medicine with subspecialty training in Neuropediatrics at the Medical University of Vienna. Her clinical and academic focus lies in neuroimmunology, with ongoing doctoral research in neuroscience examining acute necrotizing encephalitis. Dr. Eichinger’s experience spans several leading medical institutions, including Sankt Anna Children’s Hospital and the Hospital of the Brothers of Mercy in Eisenstadt, complemented by an observership in Neurointensive Care and Neuroimmunology at the Children’s Hospital of Philadelphia. She has also contributed to clinical research through her involvement in the eSMART randomized controlled trial on electronic symptom management at the Medical University of Vienna. Her expertise is further supported by certification in pediatric EEG and active participation in numerous neuropediatric congresses and workshops across Europe. Multilingual in German, English, and Spanish, Dr. Eichinger combines her clinical acumen with strong research engagement, reflected in her growing academic footprint with an h-index of 3, five peer-reviewed documents, and approximately 45 citations. Her professional pursuits integrate advanced clinical training, translational neuroscience, and a dedication to improving pediatric neurocare.

Profile: Orcid

Featured Publications

  • Eichinger, K., Breu, M., Renken, M., Siegert, S., Hilz, E., Glatter, S., Csaicsich, D., Boehm, M., Lechner, C., Kornek, B., et al. (2025). Complications of therapeutic plasma exchange in pediatric neuroimmune disorders. Children, 12(11), 1457.

  • Grasl, S., Janik, S., Dressler, A., Diehm, R., Gröppel, G., Eichinger, K., Grasl, M. C., Gstoettner, W., Feucht, M., Vyskocil, E., et al. (2021). Management and outcome of vagus nerve stimulator implantation: Experience of an otolaryngeal/neuropediatric cooperation. European Archives of Oto-Rhino-Laryngology, 278(10), 3729–3738.

Seyyed Ali Zendehbad | Clinical Neuroscience | Best Researcher Award

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Dr. Seyyed Ali Zendehbad | Clinical Neuroscience | Best Researcher Award

Dr. Seyyed Ali | Zendehbad University of Mazandaran | Iran

Dr. Seyyed Ali Zendehbad is a multidisciplinary researcher specializing in biomedical signal processing, cognitive computational neuroscience, and neurorehabilitation technologies. His research integrates deep learning, pattern recognition, and multimodal biological data modeling to enhance fatigue detection and neurorehabilitation systems. He has authored several peer-reviewed papers in reputable journals such as Scientific Reports, IEEE Access, Sensing and Bio-Sensing Research, and Healthcare Technology Letters, focusing on hybrid AI frameworks, EMG signal processing, and muscle synergy-based biofeedback mechanisms. Dr. Zendehbad’s work on developing intelligent rehabilitation systems, including his models like TraxVBF and FatigueNet, contributes to advancing telemonitoring and assistive technologies for neurological recovery. His scholarly output includes more than 25 documents, over 600 citations, and an h-index of 12, reflecting his growing impact in computational neuroscience and biomedical engineering. Recognized for innovation, he has achieved first-place awards in multiple national startup competitions and was honored with the Best Poster Award at the Congress of Neurology and Clinical Electrophysiology of Iran. As a postdoctoral researcher at the University of Mazandaran, his ongoing work emphasizes integrating trustworthy AI into telehealth systems, promoting equitable and efficient digital healthcare delivery through interdisciplinary research and technological innovation.

Profile: Orcid

Featured Publications

1. Mazrooei Rad, E., Mazinani, S. M., & Zendehbad, S. A. (2025). Diagnosis of Alzheimer’s disease using non-linear features of ERP signals through a hybrid attention-based CNN-LSTM model. Computer Methods and Programs in Biomedicine Update, 5, 100192.

2. Zendehbad, S. A., Sharifi Razavi, A., Tabrizi, N., & Sedaghat, Z. (2025). A systematic review of artificial intelligence techniques based on electroencephalography analysis in the diagnosis of epilepsy disorders: A clinical perspective. Epilepsy Research, 207, 107582.

3. Mazrooei Rad, E., Zendehbad, S. A., & Hosseinzadeh, V. (2025). Fetal QRS complex detection based on adaptive filters and peak detection. Research on Biomedical Engineering, 41(3), 424–438.

4. Zendehbad, S. A., Ghasemi, J., & Samsami Khodadad, F. (2025). FatigueNet: A hybrid graph neural network and transformer framework for real-time multimodal fatigue detection. Scientific Reports, 15(1), 640.

5. Safdel, A., Zendehbad, S. A., & Ghasemi, J. (2025). Advanced deep learning approaches for accurate and efficient suspicious behavior detection in surveillance videos. Computational Sciences and Engineering, 21(2), 1099.

Eleonora Bieber | Developmental Neuroscience | Best Researcher Award

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Dr. Eleonora Bieber | Developmental Neuroscience | Best Researcher Award

Dr. Eleonora Bieber | IRCCS Fondazione Stella Maris | Italy

Dr. Eleonora Bieber is a highly experienced neurodevelopmental disorder therapist and biomedical scientist based in Livorno, Italy, with over 15 years of expertise in pediatric neurorehabilitation, higher education, and clinical research. Her professional work integrates clinical practice with academic innovation, focusing on motor learning and imitation processes in children with Autism Spectrum Disorder (ASD) and Developmental Coordination Disorders (DCD). At the IRCCS Stella Maris Foundation in Pisa, she has played a key role in conducting clinical evaluations, designing individualized rehabilitation programs, and leading research initiatives that bridge clinical and academic environments. Her involvement in cutting-edge projects, such as INNOVATivE Technologies in Neurorehabilitation and the Artificial Intelligence and Cerebral Palsy (AINCP) project, underscores her commitment to technological innovation in neurorehabilitation. With strong skills in research design, SPSS-based data analysis, and interdisciplinary coordination, Dr. Bieber continues to contribute significantly to advancing evidence-based practices in neurodevelopmental therapy. Her scholarly impact includes 5 publications, 78 citations, and an h-index of 4, reflecting her influence in the field of neurodevelopmental research and her dedication to improving therapeutic outcomes for children through collaborative, technology-enhanced approaches.

Profiles: Scopus | Orcid

Featured Publications

Bieber, E., Smits-Engelsman, B. C. M., Sgandurra, G., Martini, G., Guzzetta, A., Cioni, G., Feys, H., & Klingels, K. (2023). Insights on action observation and imitation abilities in children with Developmental Coordination Disorder and typically developing children. Research in Developmental Disabilities, 136, 104556.

Bieber, E., Smits-Engelsman, B. C. M., Sgandurra, G., Di Gregorio, F., Guzzetta, A., Cioni, G., Feys, H., & Klingels, K. (2021). A new protocol for assessing action observation and imitation abilities in children with Developmental Coordination Disorder: A feasibility and reliability study. Human Movement Science, 78, 102717.

Buchignani, B., Beani, E., Pomeroy, V., Iacono, O., Sicola, E., Perazza, S., Bieber, E., Feys, H., Klingels, K., & Cioni, G. (2019). Action observation training for rehabilitation in brain injuries: A systematic review and meta-analysis. BMC Neurology, 19, 186.

Bieber, E., Smits-Engelsman, B. C. M., Sgandurra, G., Cioni, G., Feys, H., Guzzetta, A., & Klingels, K. (2016). Manual function outcome measures in children with developmental coordination disorder (DCD): Systematic review. Research in Developmental Disabilities, 55, 53–63.

Maria -Camelia Stancioaica | Clinical Neuroscience |

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Ms. Maria -Camelia Stancioaica | Clinical Neuroscience | Best Researcher Award

Ms. Maria -Camelia Stancioaica | Fundeni Clinical Hospital | Romania

Dr. Maria Camelia Stăncioaica is a dedicated Romanian hematologist affiliated with the Fundeni Clinical Institute in Bucharest, where she serves as the Acute Leukemia Program Coordinator. She holds an M.D. in Clinical Hematology and is currently pursuing her Ph.D. at the Carol Davila University of Medicine. Her professional development includes international experience through observership at Johns Hopkins Hospital in the USA and an internship at Pitié–Salpêtrière Hospital in France. Dr. Stăncioaica has contributed to advancing hematologic research through publications addressing acute leukemia, fungal infections in immunocompromised patients, and targeted therapies in acute myeloid leukemia. Her notable works include studies on FLT3 inhibitors, differentiation syndrome in pregnancy, and invasive fusariosis outbreaks. Actively engaged in global scientific dialogue, she has been a speaker and session chair at prominent hematology conferences across Europe. She also participates in several clinical trials as both principal and subinvestigator, focusing on novel therapeutic strategies in leukemia management. Dr. Stăncioaica’s research achievements are reflected in her 21 citations, 2 h-index, and 1 i10-index, underscoring her growing influence in clinical hematology. She is a member of the European Hematology Association and the Romanian Society of Hematology, contributing to both national and international medical communities.

Profile: Google Scholar

Featured Publications

1. Ghiaur, A., Doran, C., Gaman, M. A., Ionescu, B., Tatic, A., Cirstea, M., … Stancioaica, M. C. (2024). Acute promyelocytic leukemia: Review of complications related to all-trans retinoic acid and arsenic trioxide therapy. Cancers, 16(6), 1160.

2. Mohorea‐Neata, A. L., Ghita, M. C., Moroti, R., Ghiaur, A., Ionescu, B., Tatic, A., … Stancioaica, M. C. (2023). Invasive fusariosis in acute leukaemia patients—An outbreak in the haematology ward. Mycoses, 66(8), 705–710.

3. Droc, G., Stancioaica, M. C., Soare, C. G., Stefan, M. G., Ingustu, D., Martac, C., … Ghiaur, A. (2023). Acute promyelocytic leukemia and severe differentiation syndrome in pregnancy—A management challenge. Life, 13(5), 1141.

4. Coriu, D., & Stancioaica, M. C. (2023). Moving low-risk myelodysplastic syndromes from humans to mice: Is it truly that simple? Haematologica, 109(1), 8.

5. Stancioaica, M. C., Coriu, D., & Ghiaur, G. (2025). FLT3: A 35-year voyage from discovery to the next generation of targeted therapy in AML. Cancers.

Chun-An Cheng | Translational Neuroscience | Lifetime achievement Award

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Assist. Prof. Dr. Chun-An Cheng | Translational Neuroscience | Lifetime achievement Award

Assist. Prof. Dr. Chun-An Cheng | Tri-Service General Hospital | Taiwan

Assistant Professor Dr. Chun-An Cheng is a distinguished researcher affiliated with the Tri-Service General Hospital, Taiwan, known for his significant contributions to medical and clinical research. He has authored 73 scholarly documents, which have collectively garnered 658 citations across 620 publications, reflecting the wide impact and recognition of his scientific work. With an h-index of 14, Dr. Cheng has demonstrated consistent research productivity and influence within his field. His research encompasses multidisciplinary areas in clinical medicine, focusing on advancing diagnostic methodologies, therapeutic innovations, and patient-centered healthcare strategies. Through his collaborations and publications, Dr. Cheng has contributed to improving the understanding of complex medical conditions and enhancing evidence-based clinical practices. His dedication to translational research bridges the gap between laboratory findings and clinical applications, reinforcing his role as a key figure in the Taiwanese medical research community. Dr. Cheng continues to drive impactful studies that promote innovation, patient safety, and improved health outcomes, positioning him as a leading voice in contemporary clinical science.

Profiles: Scopus | Orcid | Research Gate

Featured Publications

  • (2025). Effects of exposure to air pollution and cold weather on acute myocardial infarction mortality. Atmosphere.

  • (2025). The risk of ischemic stroke in patients with chronic obstructive pulmonary disease and atrial fibrillation. Life.

  •  (2024). Increased risk of psychiatric disorder in patients with hearing loss: A nationwide population-based cohort study. Journal of Translational Medicine.

  • (2024). Diabetes mellitus and gynecological and inflammation disorders increased the risk of pregnancy loss in a population study. Life.

  • (2024). The influence of fine particulate matter and cold weather on emergency room interventions for childhood asthma. Life.

  • (2024). Impact of foodborne disease in Taiwan during the COVID-19 pandemic. Medicina (Lithuania).

  • (2024). Analyzing COVID-19 and air pollution effects on pediatric asthma emergency room visits in Taiwan. Toxics.

Tatsuya Yamasoba | Clinical Neuroscience | Best Researcher Award

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Prof. Tatsuya Yamasoba | Clinical Neuroscience | Best Researcher Award

Prof. Tatsuya Yamasoba | University of Tokyo | Japan

Dr. Tatsuya Yamasoba is a Professor Emeritus at the University of Tokyo and Director of Tokyo Teishin Hospital, recognized internationally for his contributions to otology, neurotology, laryngology, and clinical neuroscience. He has published over 500 scientific papers in leading journals such as Science, Nature Chemistry, Nature Nanotechnology, Neuron, PNAS, and Neurology. His research focuses on regenerative medicine for sensorineural hearing loss, vestibular dysfunction, and dysphagia management in neurodegenerative diseases. With a citation index of over 24,150, an h-index of 75, and an i10-index of 353, his work has significantly advanced understanding and treatment of auditory and balance disorders. He has developed surgical techniques for severe hearing loss, pioneered galvanic vestibular stimulation therapy for disequilibrium, and improved aspiration prevention surgeries. Dr. Yamasoba has served as Editor-in-Chief of Auris Nasus Larynx and Associate Editor for ORL Journal and npj Aging and Mechanisms of Disease. He collaborates with leading research institutions including the University of Michigan and the University of California, Davis. His professional memberships include the International Federation of ORL Societies and the Asia Oceania Otorhinolaryngology and Head and Neck Society, reflecting his leadership and influence in advancing otolaryngology and auditory neuroscience globally.

Profile: Google Scholar

Featured Publications

Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., et al. (2005). Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science, 309(5733), 481–484.

Tokunaga, T., Sakashita, M., Haruna, T., Asaka, D., Takeno, S., Ikeda, H., et al. (2015). Novel scoring system and algorithm for classifying chronic rhinosinusitis: The JESREC study. Allergy, 70(8), 995–1003.

Yamasoba, T., Lin, F. R., Someya, S., Kashio, A., Sakamoto, T., & Kondo, K. (2013). Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways. Hearing Research, 303, 30–38.

Le Prell, C. G., Yamashita, D., Minami, S. B., Yamasoba, T., & Miller, J. M. (2007). Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hearing Research, 226(1–2), 22–43.

Umezawa, K., Yoshida, M., Kamiya, M., Yamasoba, T., & Urano, Y. (2017). Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamics. Nature Chemistry, 9(3), 279–286.

Matsumoto, Y., Nichols, J. W., Toh, K., Nomoto, T., Cabral, H., Miura, Y., et al. (2016). Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nature Nanotechnology, 11(6), 533–538.

Iwasaki, S., & Yamasoba, T. (2014). Dizziness and imbalance in the elderly: Age-related decline in the vestibular system. Aging and Disease, 6(1), 38–47.

Someya, S., Xu, J., Kondo, K., Ding, D., Salvi, R. J., Yamasoba, T., Rabinovitch, P. S., et al. (2009). Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proceedings of the National Academy of Sciences, 106(46), 19432–19437.