Kiran Solingapuram Sai | Neuroimaging | Best Researcher Award

Dr. Kiran Solingapuram Sai | Neuroimaging | Best Researcher Award

Dr. Kiran Solingapuram Sai, Wake Forest School of Medicine, United States.

Dr. Kiran K. Solingapuram Sai, PhD, is an Associate Professor with tenure in the Department of Radiology at Wake Forest School of Medicine. He holds a Ph.D. in Organic Chemistry from Northern Illinois University and has extensive research experience in radiopharmaceutical chemistry. His postdoctoral training at Washington University’s Mallinckrodt Institute of Radiology focused on radiotracer development.

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✨ Early Academic Pursuits

Dr. Kiran K. Solingapuram Sai embarked on his academic journey with a strong foundation in chemistry, earning a Bachelor of Science degree in Chemistry, Biochemistry, and Microbiology from Osmania University, Hyderabad, India, in 2001. His passion for organic chemistry led him to pursue a Master of Science in the same field at Osmania University, where he honed his expertise in chemical synthesis and molecular interactions. Determined to explore the depths of organic chemistry, he pursued his Ph.D. at Northern Illinois University, DeKalb, IL, under the mentorship of Dr. Douglas A. Klumpp. During this period, his research focused on synthetic methodologies and organic reaction mechanisms, paving the way for his future contributions to medicinal and radiopharmaceutical chemistry.

🌐 Professional Endeavors

Dr. Sai’s professional journey commenced with a prestigious postdoctoral research associate position at the Mallinckrodt Institute of Radiology at Washington University in St. Louis, MO, where he worked under the guidance of Dr. Robert H. Mach. During his tenure from 2010 to 2013, he delved into the complexities of radiochemistry, developing novel radiotracers and exploring their applications in medical imaging. This experience laid the groundwork for his career in radiopharmaceutical sciences. In 2014, he joined Wake Forest School of Medicine as a Research Instructor and Chief Radiochemist, marking the beginning of his significant contributions to translational imaging and radiopharmaceutical production.

⚛️ Contributions and Research Focus

At Wake Forest School of Medicine, Dr. Sai played a pivotal role in the Department of Radiology and the Clinical Translational Science Institute (CTSI). He specialized in managing clinical and research-based radiopharmaceutical production at the Wake Forest PET Research Center. As a cyclotron manager and coordinator, he oversaw the synthesis and quality control of radiotracers essential for PET imaging. His expertise extended to the development and implementation of cGMP-approved protocols for C-11 and F-18 radiopharmaceutical production, ensuring the highest standards of safety and efficacy. His research focuses on advancing PET imaging techniques, exploring new radiotracers for diagnostic and therapeutic applications, and improving imaging biomarker development.

🏆 Accolades and Recognition

Dr. Sai’s dedication to radiochemistry and molecular imaging has earned him recognition in the scientific community. His work has been instrumental in developing radiopharmaceuticals for neurological and oncological imaging, contributing significantly to early disease detection and targeted therapy. His contributions have been acknowledged through numerous research grants, collaborative projects, and publications in high-impact scientific journals. His commitment to excellence and innovation has positioned him as a leading figure in the field of radiopharmaceutical sciences.

🔬 Impact and Influence

Beyond his research and technical expertise, Dr. Sai has mentored budding scientists and researchers in the field of radiochemistry and imaging sciences. His guidance has helped shape the next generation of radiopharmaceutical experts, fostering a culture of innovation and scientific curiosity. His role in translational imaging programs has bridged the gap between basic research and clinical applications, directly impacting patient care by improving diagnostic imaging techniques.

💡 Legacy and Future Contributions

Dr. Sai’s work continues to inspire advancements in molecular imaging and radiopharmaceutical development. As an Associate Professor with tenure at Wake Forest School of Medicine, he remains dedicated to pushing the boundaries of radiochemistry, developing cutting-edge imaging agents, and enhancing the precision of diagnostic medicine. His legacy in the field is defined by his unwavering commitment to scientific discovery, translational research, and the continuous pursuit of excellence in radiopharmaceutical sciences.Dr. Kiran K. Solingapuram Sai’s contributions to the field of radiopharmaceutical chemistry stand as a testament to his dedication, innovation, and impact on medical imaging and healthcare. His journey from a passionate chemistry student to a distinguished professor and researcher highlights the transformative power of science in shaping the future of medicine.

 

Publication

  1. Radiation-induced brain injury in non-human primates: A dual tracer PET study with [11C]MPC-6827 and [11C]PiB

    • Authors: Naresh Damuka, George W. Schaaf, Mack Miller, Caleb Bradley, Bhuvanachandra Bhoopal, Ivan Krizan, Krishna K. Gollapelli, Christopher T. Whitlow, J. Mark Cline, Kiran K. Solingapuram Sai
    • Year: 2025

 

  1. The β-Secretase 1 Enzyme as a Novel Therapeutic Target for Prostate Cancer

    • Authors: Hilal A. Rather, Sameh Almousa, Ashish Kumar, Mitu Sharma, Isabel Pennington, Susy Kim, Yixin Su, Yangen He, Abdollah R. Ghara, Kiran Kumar Solingapuram Sai et al.
    • Year: 2023

 

  1. Development and Optimization of 11C-Labeled Radiotracers: A Review of the Modern Quality Control Design Process

    • Authors: Paul Josef Myburgh, Kiran Kumar Solingapuram Sai
    • Year: 2023

 

  1. Binding Parameters of [11C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents

    • Authors: Avinash H. Bansode, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Ivan Krizan, Mack Miller, Suzanne Craft, Akiva Mintz, Kiran Kumar Solingapuram Sai
    • Year: 2023

 

  1. PET Imaging of [11C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains

    • Authors: Naresh Damuka, Paul W. Czoty, Ashley T. Davis, Michael Nader, Susan H. Nader, Suzanne Craft, Shannon L. Macauley, Lindsey K. Galbo Thomma, Phillip M. Epperly, Christopher T. Whitlow et al.
    • Year: 2020

 

  1. One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists

    • Authors: Nagaraju Bashetti, J.V. Shanmukha Kumar, Naresh Varma Seelam, B. Prasanna, Akiva Mintz, Naresh Damuka, Sriram Devanathan, Kiran Kumar Solingapuram Sai
    • Year: 2019

 

Conclusion

Dr. Kiran K. Solingapuram Sai has established himself as a leading expert in radiopharmaceutical sciences, contributing significantly to translational imaging research. His work in PET radiopharmaceutical production and quality assurance underscores his role in advancing medical imaging techniques. His academic and research contributions make him a valuable asset in the field of radiology and molecular imaging.

Jing Sun | Cerebrovascular disease | Best Researcher Award

Dr. Jing Sun | Cerebrovascular disease | Best Researcher Award

Dr. Jing Sun, China-Japan Union Hospital of Jilin University, China.

Dr. Jing Sun, a prominent researcher and attending physician at the China-Japan Union Hospital of Jilin University, has made significant contributions to the field of neurology, particularly in the areas of cerebrovascular diseases and cognitive disorders. She earned her Doctor of Medicine degree from Jilin University in 2017 and has since focused her research on understanding the molecular mechanisms behind stroke, neuroinflammation, and brain injury. Her work has been widely published, with over 10 SCI papers, many of which highlight her pioneering research on the MAPK signaling pathway and NLRP3 inflammasome in neurological disorders.

 

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Early academic pursuits 🎓

Dr. Jing Sun’s academic journey began at Jilin University, one of China’s leading institutions for medical education. She earned her Master’s degree in Neurology from the First Affiliated Hospital of Jilin University in 2013, where she honed her foundational knowledge in neuroscience. Her pursuit of deeper insights into the human brain led her to continue at Jilin University for her Doctor of Medicine degree, which she successfully obtained in 2017. Her academic curiosity and dedication during her early years in medicine shaped her future focus on cerebrovascular and cognitive disorders. It was here that she began to appreciate the complexity of neurological diseases and developed an intense interest in stroke and its associated pathophysiology.

Professional endeavors in cerebrovascular research 🧠

Following her graduation, Dr. Sun embarked on her professional career at the China-Japan Union Hospital of Jilin University, where she has been an attending physician since 2017. Her clinical practice centers on cerebrovascular diseases and cognitive impairments, which are crucial areas of study in modern neurology. As an attending physician, Dr. Sun not only engages with patients but also leads research on stroke, neuroinflammation, and neurovascular unit damage. Her combination of hands-on clinical experience and a deep passion for research has allowed her to bridge the gap between theoretical understanding and practical application, significantly advancing her research on neurological diseases.

Contributions and research focus 🔬

Dr. Sun’s research is primarily focused on cerebrovascular and cognitive disorders, with an emphasis on understanding the molecular pathways that lead to brain injuries such as strokes and neuroinflammation. She has explored the role of the mitogen-activated protein kinase (MAPK) signaling pathway as a potential target for stroke therapies, contributing significantly to the understanding of molecular mechanisms behind neurological diseases. Her work extends to investigating neuroinflammatory processes, specifically the NLRP3 inflammasome, and how it contributes to brain injury and dysfunction after stroke. Dr. Sun’s research findings have been published in top-tier journals, with several of her papers listed as first or corresponding author contributions.

Impact and recognition in the research community 🌍

Dr. Sun’s contributions to the field of neurology have not gone unnoticed. She has published more than 10 scientific papers in esteemed peer-reviewed journals, with many of them focusing on key aspects of cerebrovascular disease and neuroinflammation. Her work on the MAPK signaling pathway and the role of the NLRP3 inflammasome in neurological disorders has garnered significant attention in the scientific community. She has also played a key role in securing funding for her research, having presided over a Natural Science Fund of Jilin Province. Furthermore, her presentation at the ICAS Joint Conference in 2016 earned her the Best Poster Presentation Award, underscoring her ability to communicate complex scientific ideas effectively.

Awards and accolades 🏆

Dr. Sun’s hard work and dedication have been recognized both within and outside her institution. In addition to her prestigious academic background, she received the Best Poster Presentation Award at the ICAS Joint Conference in 2016, an accolade that reflected the quality of her research and its potential to contribute to advancements in medical science. Her growing list of awards includes several recognitions for her academic excellence and commitment to research. These accolades highlight her as one of the leading researchers in the field of cerebrovascular and cognitive disorders, particularly in the area of stroke research.

Future contributions and legacy 🌱

Looking ahead, Dr. Sun’s research trajectory remains focused on unraveling the complexities of stroke, neuroinflammation, and cognitive disorders. She is committed to identifying new therapeutic targets that could lead to more effective treatments for stroke victims and individuals suffering from related neurodegenerative conditions. Her legacy is likely to include groundbreaking discoveries that change the way we understand brain injuries and diseases. As she continues to make strides in her research, Dr. Sun aims to contribute to more personalized and precise medical interventions in neurology. Her career trajectory promises a future where her work will not only influence the scientific community but also provide tangible benefits to patients suffering from cerebrovascular and cognitive disorders.

Mentorship and influence on the next generation of researchers 🌟

Dr. Sun is not just a researcher but also a mentor, dedicated to shaping the next generation of neurologists and scientists. Through her work at the China-Japan Union Hospital of Jilin University, she provides guidance and mentorship to young researchers, particularly those interested in cerebrovascular diseases and neuroinflammation. Her ability to inspire and educate future medical professionals ensures that her impact will extend beyond her own research. By cultivating a culture of excellence and inquiry, Dr. Sun is influencing the next wave of scientific minds who will continue to explore and address the most pressing neurological challenges of our time.

Research impact and clinical applications 💉

Dr. Sun’s research is not only pivotal in the theoretical realm but also holds significant clinical value. Her work has led to the identification of new biomarkers and potential drug targets for treating stroke and related neurovascular disorders. The intersection of her clinical expertise and research in molecular mechanisms positions her to contribute to the development of novel therapeutic approaches. In particular, her studies on neuroinflammation and the NLRP3 inflammasome could lead to more effective treatments for stroke recovery and prevention of long-term cognitive decline. Dr. Sun’s research continues to push the boundaries of both basic science and clinical practice, creating tangible benefits for the treatment of neurological diseases.

📚 Publications

  • Title: The Role of Major Facilitator Superfamily Domain-Containing 2a in the Central Nervous System
    Authors: Zhidong He, Yanan Zhao, Jing Sun
    Year: 2023

 

  • Title: Case Report: Early-Onset Guillain-Barre Syndrome Mimicking Stroke
    Authors: Jing Sun
    Year: 2021

 

  • Title: The Mechanisms of Type 2 Diabetes-Related White Matter Intensities: A Review
    Authors: Jing Sun
    Year: 2020

 

  • Title: NLRP3 Inflammasome Contributes to Neurovascular Unit Damage in Stroke
    Authors: Jing Sun, Lumei Chi, Zhidong He, Yu Gao, Yufei Gao, Yujing Huang, Guangxian Nan
    Year: 2019

 

  • Title: Nonspecific Dizziness as an Unusual Presentation of Neurocysticercosis: A Case Report
    Authors: Jing Sun
    Year: 2019

 

  • Title: Anti-inflammatory Effects of Fimasartan via Akt, ERK, and NFκB Pathways on Astrocytes Stimulated by Hemolysate
    Authors: Jing Sun
    Year: 2016

 

  • Title: Cerebral Venous Sinus Thrombosis Presenting with Multifocal Intracerebral Hemorrhage and Subarachnoid Hemorrhage: A Case Report
    Authors: Jing Sun

 

  • Title: Pretreatment with Low-Dose Fimasartan Ameliorates NLRP3 Inflammasome-Mediated Neuroinflammation and Brain Injury After Intracerebral Hemorrhage
    Authors: Jing Sun

 

  • Title: The Extracellular Signal-Regulated Kinase 1/2 Pathway in Neurological Diseases: A Potential Therapeutic Target (Review)
    Authors: Jing Sun

 

  • Title: The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway as a Discovery Target in Stroke
    Authors: Jing Sun
    Year: 2016

 

Conclusion

Dr. Jing Sun’s contributions to cerebrovascular and cognitive disorder research have made a lasting impact on both the scientific community and clinical practice. Her innovative work continues to uncover new therapeutic avenues for stroke and neuroinflammatory conditions, advancing our understanding of these complex diseases. As she continues to build on her achievements, Dr. Sun is poised to make even greater contributions to the field, not only through her research but also by inspiring and mentoring future generations of medical professionals and scientists. Her legacy promises to significantly improve the diagnosis, treatment, and prevention of neurological diseases, shaping the future of neurology for years to come.